|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population显示文摘AIM: To study the association between APOE polymorphisms and cerebral infarction through a case-control study among the Chinese Han population. METHODS: First-ever cerebral infarction patients (n=226) whose ages ranged from 40 to 60 years old were recruited from Department of Neurology, Zhongshan Hospital, Shanghai, and Zhejiang Chinese Traditional Medicine Hospital, Zhejiang, China. Unrelated healthy controls (n=201) were selected from the general population in the same area with similar age and sex distribution. APOE was amplified by one-stage PCR using the forward primer: 5’-GGC ACG GCT GTC CAA GGA GCT-3’ and reverse primer: 5’-GAT GGC GCTGAG GCC GCG CT-3’. The PCR product was digested directly with 5 U of CfoI and separated by a 20 % polyacryla- mide (acrylamide: bis-acrylamide=29:1) nondenaturing gel. RESULTS: Both cerebral infarction patient and control groups were in Hardy-Weinberg equilibrium. The allele frequency of APOE*2, APOE*3, and APOE*4 was 4.6 %, 81.9 %, and 13.5 % respectively in the patients with cerebral infarction; 5.7 %, 87.3 %, and 7.0 % respectively in the healthy control group. Compared with APOE3/3 subjects, APOE4/4 carriers had a 2.1-fold risk of cerebral infarction (odds ratio 2.1, 95 % confidence limits 1.3 to 3.4). The allele frequency of APOE*4 in the cerebral infarction patient group was significantly higher than that in the control group (13.5 % vs 7.0 %; P=0.002). CONCLUSION: APOE 4 is a risk factor for cerebral infarction among the Chinese Han population. | Zhu-qingJIN Yong-shengFAN JingDING MeiCHEN WeiFAN Guang-jiZHANG Bin-huiZHANG Suo-jingYU Yong-shengZHANG Wei-fengJI Jian-gangZHANG | 2004 | Acta Pharmacologica Sinica2004，25，3： | 18 |
| 2 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 3 | Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity显示文摘在植物免疫,激活病原体的细胞内部的核苷酸绑定 / 白氨酸富人重复(NLR ) 受体动员疾病抵抗小径,但是下游的发信号机制仍然保持阴暗。(EDS1 ) 提高的疾病危险性 1 在 Toll-Interleukin1-Receptor 触发的抵抗控制 transcriptional reprogramming 域(TIR ) 家庭 NLR (TNL ) 。水杨酸酸(SA ) 的 Transcriptional 正式就职荷尔蒙防卫部门对 biotrophic 病原体提供一个关键障碍。这里,我们现在的基因、分子的证据在 Arabidopsis ? 有它的搭挡 PAD4 的 EDS1 建筑群 ? 禁止 MYC2,反对 SA jasmonic 酸(JA ) 的一个主人管理者荷尔蒙小径。在 TNL 有免疫力的反应,有 MYC2 的 EDS1/PAD4 干扰独立于导致 EDS1 的 SA 合成增加 SA 防卫部门,有效地从而堵住一个有势力的行动细菌的 JA 模仿, coronatine (英国管) 。我们证明在英国管在 nucle 剔 ? 畦据楴湯椠 ? 牁 'L 摩灯楳? 晡敦瑣 ? 桴 ? 硥牰獥楳湯漠 ? 内被察觉到以后, MYC2 的那对抗发生 ? 楬業整 ? ?獢瑥漠 ? 敧敮 ? 潣瑮潲汬摥戠 ? 剐至 ? 佐奌佃 ? 删偅 ? 卓噉? 佃偍 ???? 湩汣摵湩 ? 桴 ? 汦睯牥湩 ? 楴敭爠来汵瑡牯吗?? | Haitao Cui Jingde Qiu Yue Zhou Deepak D. Bhandari Chunhui Zhao Jaqueline Bautor Jane E. Parker | 2018 | Molecular Plant2018，11，8： | 10 |
| 4 | Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages显示文摘Neuroinflammation has been recognized as a factor in the pathogenesis of neurodegenerative diseases.Emerging evidence suggests that peripheral inflammation,besides neuroinflammation,functions as a modulator of disease progression and neuropathology in several neurodegenerative diseases.However,detailed correlations among peripheral inflammation,neuroinflammation and neurodegeneration remain unknown.In the present study,we prepared a peripheral inflammation model with lipopolysaccharides(LPS)-stimulated RAW264.7 macrophages to explore its activation on BV2 microglia.We found that LPS induced the production of IL-1 β,IL-6 and TNF-α in the culture medium of RAW264.7 macrophages.We further showed that LPS plus ATP activated inflammasome,evidenced by the upregulation of caspase-1 and IL-1β,which was suppressed by ZYVAD,a caspase-1 inhibitor.Furthermore,the conditioned medium obtained from LPS-treated RAW264.7 macrophages activated BV2 microglia,stimulating the release of IL-1β,IL-6 and TNF-a from BV2 cells.ZYVAD pretreatment markedly suppressed BV2 microglia activation induced by RAW264.7 cells conditioned medium.Taken together,our study indicates that macrophage-mediated peripheral inflammation subsequently evokes neuroinflammation and may aggravate neural damage.Inflammasome and caspase-1 may be potential targets for modulating systemic inflammatory responses in neurodegenerative diseases. | Yang Pan Bo Shen Qin Gao Jun Zhu Jingde Dong Li Zhang Yingdong Zhang | 2016 | The Journal of Biomedical Research2016，30，3： | 5 |
| 5 | FT Ⅰ, a novel positive myeloid-lineage-specific transcription regulatory element within the mouse myeloperoxidase gene enhancer, En 1显示文摘FT Ⅰ (AAAAGGGGAAGCAGAG), a poly purine ele-ment within the myloid-lineage specific enhancer (En 1) of the mouse myeloperoxidase gene [1, 2] has been fur-ther characterised. 1, FT Ⅰ functions as a myeloid-lineage specific transcription regulatory element; 2, WEHI 3BD+ cells have higher binding activity to FT Ⅰ and express the proteins which could form the unique DNA-protein com-plex(es) of FT Ⅰ;. 3, The essential sequence for the specific DNA-protein interactions of FT Ⅰ is AAAAGGGGAAGC; 4, South-western analysis in conjunction with the compe-tition assay of the proteins binding to FT Ⅰ, has revealed a 28 kd protein in WEHI 3BD+ cells that displays the properties of the putative transcription factor which acts through FT Ⅰ. These new findings have demonstrated both the functional myeloid-lineage specificity and the novelty of FT Ⅰ. | ZHU JINGDE (CRC Department of Medical Oncology, CRC Beat son Laboratories, Glasgow University, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kngdom. Tel: 44141942 9361 Fax: 44141 330 4127. e-mail:gpma66@udcf. gla. ac. uk ) | 1995 | Cell Research1995，5，1： | 4 |
| 6 | A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model显示文摘Liver cancer is one of the most threatening diseases in Chinese population. Just like in other tissues, tumor initiation and development in liver involve multiple steps of genetic and epigenetic alterations with several unknown details. However, unlike in other tissues, a tis-sue specific inducible Cre recombinase system that allows temporal and spatial deletion of a target DNA fragment is still not available for in vivo functional gene annotation in hepatocytes. In our pursuit to establish such a mouse model, we designed a dual inducible Cre transgene system and tested it in cultured cells. By combining a CCAAT/enhancer binding protein β (C/EBP β) promoter derived Tet-off expression system and the estrogen receptor (ER) mediated functional control, we show a desirable profile of both hepatocyte-specificity and regulability of the Cre expression in a series of critical assessments in the cell culture system, which provides confidence in continua-tion of our ongoing pursuit in mouse. | Yu Wu Yinghua He Hongyu Zhang Xinlan Dai Xiaoyu Zhou Jun Gu Guan Wang Jingde Zhu | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 7 | Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge incineration显示文摘在污泥焚化,重金属的热行为是一颗成长担心。在这个工作,在有约束力的精力划分在蒸汽阶段和压缩阶段,在压缩阶段的种形成再分配和金属种类的差别之间的行为的金属的联合分析被执行在高温度的污泥焚化调查重金属的可能的挥发冷凝作用机制。在金属挥发有二步,这被发现。重金属的起始的挥发发源从他们的可交换(EXC ) ,碳酸盐界限(汽车) 和部分,它是首先简单物质,氯化物,氧化物和硫化物填写了的铁锰界限(FM ) 。随在污泥的氯和硫的增加,重金属的内部种形成再分配在压缩阶段发生了,它是影响重金属的潜在的轻快的一个重要因素。有 complexed (COM ) 和部分逐渐地分解了成简单物质或离子,氧化物和碳酸盐的剩余(物件) 的金属种类部分的 A,它显著地加强了第二轻快。在氯的存在,当 Cd 的轻快率增加了 44.89% 时,有 RES 部分的大约 46% Cd 消失了。而且,当处于挥发率有将近 10% 的增加时,有 COM 部分的大约 9% Pb 消失了。因此,第二挥发被金属种类的分解主要与 COM 和物件部分控制。由 XRD 分析和有约束力的精力计算的优点,它被发现那金属复杂,硅酸盐被使倾向作为与硫酸盐相比由于差的 thermo 稳定性在高温度下面分解。 | Jingde LUAN Rundong LI Zhihui ZHANG Yanlong LI Yun ZHAO | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 3 |
| 8 | The microbial metallogeny of weathering crust REE deposits in South China显示文摘VERY little is known about the roles of microorganisms in the metallogeny of weathering crust REE deposits, although there has been much literature on REE behavior in weathering conditions. The present note deals with the microorganisms in 4 weathering profiles of an REE deposit and their roles in migration and accumulation of REE in weathering conditions. 1 Cultivation and identification of microorganisms Under strict sterilization, samples were collected from various parts of 4 weathering profiles of granites in a weathering crust REE deposit in South China. The samples were then cultivated for microorganisms with ordinary agars as culture media and then the cultivated microorganisms were dyed and identifiedunder a microscope. The sampled positions and cultivated numbers of microbial colonies are shown | CHEN Binghui~(1,2), WANG Zhimei~3, HUANG Limei~3, WU Fuhai~3, CHEN Jingde~2 and XU Wenlie~2 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth Sciences, Zhongshan University, Guangzhou 510275, China 3. Guangdong Pharmaceutical College, Guangzhou 510244, China | 1999 | Chinese Science Bulletin1999，44，S2： | 3 |
| 9 | Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8(SAMP8) mice显示文摘Memantine is a N-methyl-D-aspartate(NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease(AD).Environmental enrichment(EE) has shown significant beneficial effects on functional improvement in AD.In this study,we sought to determine whether combining these two distinct therapies would yield greater benefit than either drug used alone.We investigated the effect of memantine combined with EE on spatial learning and memory and AD-like pathology in a widely used AD model,the senescence-accelerated prone mice(SAMP8).The SAMP8 mice were randomly assigned to enriched housing(EH) or standard housing(SH),where either memantine(20 mg/kg) or saline was given by gastric lavage once daily continuously for eight weeks.Our results showed that,when provided separately,memantine and EE significantly improved spatial learning and memory by shortening escape latencies and increasing the frequency of entrance into the target quadrant.When combined,memantine and EE showed additive effect on learning and memory as evidenced by significant shorter escape latencies and higher frequency of target entrance than either drug alone.Consistent with the behavior results,pathological studies showed that both memantine and EE significantly reduced hippocampal CA1 neurofibrilliary tangles(NFTs) as well as amyloid beta precursor protein(APP) levels.Combining both therapies synergistically lessened NFTs and APP expression compared to either drug alone in SAMP8 mice,indicating that the combination of memantine with EE could offer a novel and efficient therapeutic strategy for the treatment of AD. | Jingde Dong Mi Zhou Xiaoqiang Wu Mingyang Du Xiaoshan Wang | 2012 | The Journal of Biomedical Research2012，26，6： | 2 |
| 10 | Subjective poor sleep quality in Chinese patients with Parkinson's disease without dementia显示文摘Parkinson's disease (PD) is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr (H&Y) staging have been demonstrated. However, the relationship between sleep disorders and H&Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H&Y classification. We found that night sleep quality was significantly associated with the severity of PD (P=0.008). Panic disorder severity scale (PDSS) total scores were correlated with PD non-motor symptoms scale (PDNMS) scores (r=-0.528, P<0.001), the Hamilton depression scale (HAMD) scores (r=-0.545, P<0.001) and the Hamilton anxiety scale (HAMA) scores (r=-0.498, P<0.001). Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in nondemented patients with PD. | Li Zhang Jingde Dong Weiguo Liu Yingdong Zhang | 2013 | The Journal of Biomedical Research2013，27，4： | 2 |
| 11 | Effects of chronic peripheral pretreatment with an angiotensin II type-1 receptor blocker on apoptosis-related molecules in rats with cerebral ischemia/reperfusion injury显示文摘Chronic systemic treatment with blockers of angiotensin II type-1(AT1) receptors inhibits ischemia-induced apoptosis and reduces ischemic neuronal damage.However,the molecular mechanisms of AT1 receptor blockers in modulating neuronal apoptosis remain poorly understood.Pretreatment with irbesartan significantly suppressed cell apoptosis at 1-7 days following cerebral ischemia/reperfusion,increased levels of brain-derived neurotrophic factor,and elevated the ratios of Bcl-2/Bax and phosphorylated cyclic adenosine monophosphate response element-binding protein(pCREB)/CREB in the ischemic cortex at 1 day after reperfusion,as well as suppressing caspase-3 activation.Cerebral ischemia increased the mRNA expression of AT1 and AT2 receptors in the ischemic cortex,whereas irbesartan blocked this increase in AT1 expression but potentiated the expression of AT2.Therefore,this AT1 receptor blocker was neuroprotective by increasing the ratios of Bcl-2/Bax and pCREB/CREB,increasing brain-derived neurotrophic factor levels,inhibiting caspase-3 activation,and modulating AT receptor expression. | Jingping Shi Jingde Dong Jie Lu Yingdong Zhang | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 12 | ZIF-7@carbon composites as multifunctional interlayer for rapid and durable Li-S performance显示文摘The notorious'shuttle effect'of polysulfide during charge-discharge process induces grievous capacity fading,while the sluggish polysulfide conversion kinetics significantly hinders the development of practically viable lithium-sulfur(Li-S)batteries.In this study,a novel ZIF-7@carbon composite with ZIF-7 sheets vertically rooted on carbon cloth was developed as multifunctional interlayer to address these issues.The composite shows directional layered structure with outstanding compactness,and thus can provide massive active sites for accelerated redox reactions.The pore channels are perpendicular to the square surface,resulting in extremely high utilization of one-dimensional channels.Therefore,this structure can not only maintain the structural stability during the charge-discharge process by providing enough space for volume expansion,but also contribute to efficient exposure and utilization of active sites for the physical/chemical adsorption and catalytic conversion of polysulfide.As a result,Li-S batteries with the as-developed interlayer deliver a considerable areal capacity of 4.75 mAh cm^(-2) at an elevated sulfur loading of 5.5 mg cm^(-2),and an impressive cyclability with an extremely low capacity-fading rate of merely 0.04%per cycle over 500 cycles at 1 C. | Xingbo Wang Yan Zhao Feichao Wu Shuming Liu Zisheng Zhang Zhaoyang Tan Xiaohang Du Jingde Li | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 13 | Pyrrolic- structure enriched nitrogen doped graphene for highly effi- cient next generation supercapacitors 显示文摘 | HASSAN F M CHABOT V LI Jingde | 2013 | Journal of Mate- rials Chemistry A2013，，1： | 1 |
| 14 | Diffusion theory of slow responds显示文摘 | LI Jingde CHEN Min ZHENG Feng | 1997 | Science in China:Series A1997，40，3： | 1 |
| 15 | Fabrication and properties of Fe3Al-Al2O3graded coatings显示文摘 | Jingde Zhang Yansheng Yin Jing Li | 2003 | Journal of Materials Processing Technology2003，134，2： | 1 |
| 16 | Preparation, microstructure and properties of yttrium aluminum garnet fibers prepared by sol–gel method显示文摘 | Chengshun Li Yujun Zhang Hongyu Gong Jingde Zhang Lifang Nie | 2008 | Materials Chemistry and Physics2008，，1： | 1 |
| 17 | Fabrication and properties of Fe3 Al-Al2O3 graded coatings 显示文摘 | ZHANG Jingde YIN Yansheng LI Jing etal | 2003 | J Mater Process Technol2003，134，2： | 1 |
| 18 | Synthesis of nucleated glass-ceramics using oil shale fly ash显示文摘 | Luan Jingde Li Aimin Su Tong | 2010 | Journal of Hazardous Materials2010，173，13： | 1 |
| 19 | A General Framework for Debugging显示文摘 | KEIJRO A ZENGO F JINGDE C | 1991 | IEEE Software1991，，： | 1 |
| 20 | Application and study on the models of predicting wear failure in the mechanical equipment显示文摘 | Guoquan R Haiqi Z Jingde | 2001 | Proceedings of the International Symposium on Test and Measunrement2001，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员