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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 3 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 4 | Key technologies and equipment for a fully mechanized top-coal caving operation with a large mining height at ultra-thick coal seams显示文摘 | Jinhua Wang Bin Yu Hongpu Kang Guofa Wang Debing Mao Yuntao Liang Pengfei Jiang | 2015 | International Journal of Coal Science & Technology2015，2，2： | 57 |
| 5 | An Exploratory Analysis of Vegetation Strategies to Reduce Shallow Landslide Activity on Loess Hillslopes, Northeast Qinghai-Tibet Plateau, China显示文摘Heavy summer rainfall induces significant soil erosion and shallow landslide activity on the loess hillslopes of the Xining Basin at the northeast margin of the Qinghai-Tibet Plateau. This study examines the mechanical effects of five native shrubs that can be used to reduce shallow landslide activity. We measured single root tensile resistance and shear resistance, root anatomical structure and direct shear and triaxial shear for soil without roots and five root- soil composite systems. Results show that Atriplex canescens (Pursh) Nutt. possessed the strongest roots, followed by Caragana korshinskii Kom., Zygophyllum xanthoxylon (Bunge) Maxim., Nitraria tangutorum Bobr. and Lycium chinense Mill. Single root strength and shear resistance relationships with root diameter are characterized by power or exponential relations, consistent with the Mohr- Coulomb law. Root mechanical strength reflects their anatomical structure, especially the percentage of phloem and xylem cells, and the degree and speed of periderm lignifications. The cohesion force of root- soil composite systems is notably higher than that of soil without roots, with increasing amplitudes of cohesion force for A. canescens, C. korshinskii, Z. xanthoxylon, N. tangutorum and L. chinense of 75.9%, 75.1%, 36.2%, 24.6% and 17.0 % respectively. When subjected to shear forces, the soil without root samples show much greater lateral deformation thanthe root-soil composite systems, reflecting the restraining effects of roots. Findings from this paper indicate that efforts to reduce shallow landslides in this region by enhancing root reinforcement will be achieved most effectively using A. canescens and C. korshinskii. | HU Xia-song BRIERLEY Gary ZHU Hai-li LI Guo-rong FU Jiang-tao MAO Xiao-qing YU Qin-qin QIAO Na | 2013 | Journal of Mountain Science2013，10，4： | 41 |
| 6 | Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells显示文摘这研究检验了 shikonin 导致的发信号的事件在 Bcr/Abl-positive 导致 apoptosis 的正式就职长期的骨髓内产生的白血病(电流型逻辑) 房间(例如, K562, LAMA84 ) 。有 shikonin 的 K562 细胞的处理(例如, 0.5 M )导致了反应的氧种类( ROS )的快速的产生伴随的 apoptosis 的深刻正式就职,打击 c-Jun-N-terminal kinase ( JNK )和 p38 的激活, mitochondrial 蛋白质细胞色素 c 和 Smac/DIABLO 的显著版本, PARP 的 caspase-9 和-3,和劈开的激活。完全 ROS 清除堵住了所有上述事件(即, apoptosis 的 JNK 和 p38 phosphorylation,细胞色素 c 和 Smac/DIABLO 版本, caspase 和 PARP 劈开,以及正式就职) 后面的 shikonin 处理。JNK 的抑制并且 JNK1 击倒显著地稀释的细胞色素 c 版本, caspase 劈开和 apoptosis,但是没影响调停 shikonin 的 ROS 生产。另外, caspase 激活的抑制完全堵住了导致 shikonin 的 apoptosis,但是有点没修改调停 shikonin 的细胞色素 c 版本或 ROS 产生。总的来说,这些调查结果证明导致 shikonin 的氧化损害在 apoptotic 发信号在一个近似的点操作串联,并且随后激活,并且导致 apoptosis 压力相关的 JNK 小径,扳机 mitochondrial 机能障碍,细胞色素 c 版本,和 caspase 激活。我们的数据也建议 shikonin 可以是为电流型逻辑的处理的一个有希望的代理人,, ROS 的一个发电机。 | Xin Mao Chun Rong Yu Wen Hua Li Wen Xin Li | 2008 | Cell Research2008，18，8： | 31 |
| 7 | Solid state fermentation of rapeseed cake with Aspergillus niger for degrading glucosinolates and upgrading nutritional value显示文摘Background:Rapeseed cake is a good source of protein for animal feed but its utilization is limited due to the presence of anti-nutritional substances,such as glucosinolates(GIs),phytic acid,tannins etc.In the present study,a solid state fermentation(SSF) using Aspergillus niger was carried out with the purpose of degrading glucosinolates and improving the nutritional quality of rapeseed cake(RSC).The effects of medium composition and incubation conditions on the GIs content in fermented rapeseed cake(FRSC) were investigated,and chemical composition and amino acid in vitro digestibility of RSC substrate fermented under optimal conditions were determined.Results:After 72 h of incubation at 34℃,a 76.89%decrease in GIs of RSC was obtained in solid medium containing 70%RSC,30%wheat bran at optimal moisture content 60%(w/w).Compared to unfermented RSC,trichloroacetic acid soluble protein(TCA-SP),crude protein and ether extract contents of the FRSC were increased(P< 0.05) 103.71,23.02 and 23.54%,respectively.As expected,the contents of NDF and phytic acid declined(P< 0.05) by 9.12 and 44.60%,respectively.Total amino acids(TAA) and essential amino acids(EAA) contents as well as AA in vitro digestibility of FRSC were improved significantly(P< 0.05).Moreover,the enzyme activity of endoglucanase,xylanase,acid protease and phytase were increased(P<0.05) during SSF.Conclusions:Our results indicate that the solid state fermentation offers an effective approach to improving the quality of proteins sources such as rapeseed cake. | Changyou Shi Jun He Jie Yu Bing Yu Zhiqing Huang Xiangbing Mao Ping Zheng Daiwen Chen | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 32 |
| 8 | Dynamic change of mother-source neutralizing antibodies against enterovirus 71 and coxsackievirus A16 in infants显示文摘背景 Enterovirus 71 (EV71 ) 和 coxsackievirus A16 (考克斯 A16 ) 是为手,脚和嘴疾病(HFMD ) 的主要原因的代理人。研究显示经常的 HFMD 爆发导致一些百孩子在最近的年里的中国的死亡。为 HFMD 的疫苗和另外的研究需要着急地被发展。我们的学习的目的是:探索从江苏省在婴儿对 EV71 和考克斯 A16 抵销抗体的母亲来源的动态开发,中国,并且为相应免疫 course.Methods 外设血样品的进一步的建立提供基本数据在年龄的二和七个月在交货和他们的婴儿前立即来自 133 个生产女人是镇定的一次。微剂量的 cytopathogenic 效果的方法被用来测量在出生前的女人对 EV71 和考克斯 A16, anti-EV71 的 respectively.Results Seropositive 率和反艇长 A16 抵销抗体是 79.7%(106/133 ) 并且 92.5%(123/133 ) 分别地;几何吝啬的 titers (GMT ) 是 29.0 和 61.9;75.9%(101/133 ) 出生前的女人在 anti-EV71 和反艇长 A16 两个都是积极的;anti-EV71 和反艇长 A16 的 seropositive 率是 25.6%(34/133 ) 并且 38.3%(51/133 ) 在在二月年龄的婴儿;GMT 分别地是 12.3 和 18.0。anti-EV71 的 GMT 在二个月与那相比为在七个月(82.6 ) 的婴儿是显著地更高的(P < 0.05 ) ,出现婴儿不显著地在二~七个月期间由 EV71 感染了。尽管仅仅在七个月的一个后代(0.75%) 被发现有反艇长, A16 转了从母亲,这观察建议没有母亲的抗体可以在 EV71 和考克斯 A16 的流行是的七 months.Conclusions 留在婴儿在江苏相对高省。对 EV71 和考克斯 A16 的二原子价的疫苗应该被开发,并且为为婴儿的主要免疫的理想的时间点在年龄的 2-5 月附近。 | MAO Qun-ying LIAO Xue-yan YU Xiang LI Nan ZHU Feng-cai ZENG Ying LIANG Zheng-lun LI Feng-xiang WANG Jun-zhi LU Feng-min ZHUANG Hui | 2010 | Chinese Medical Journal2010，，13： | 29 |
| 9 | A Gain-of-Function Mutation in OslAA11 Affects Lateral Root Development in Rice显示文摘侧面的根对为营养素和水的举起的植物重要。Aux/IAA 家庭的几个成员被显示了在侧面的根开发起关键作用。这里,米饭 Aux/IAA 家庭基因的一个成员, OsIAA11 (LOC_Os03g43400 ) ,在侧面的根开发从一个米饭异种有缺陷者被孤立。在 OsIAA11 的 gain-of-function 变化严格地堵住侧面的根的开始 primordia,而是它不影响王冠根开发。OsIAA11 的表示在根尖端,侧面的根帽子,石碑,和侧面的根 primordia 被定义。植物生长素记者 DR5GUS (-glucuronidase) 比在在异种在底层被表示野类型,显示那 OsIAA11 涉及在根帽子发信号的植物生长素。抄本许多 OsPIN1b 和 OsPIN10a 在 Osiaa11 异种的根尖端被减少。一起拿,结果显示在 OsIAA11 的 gain-of-function 变化在米饭引起了侧面的根开发的抑制。 | Zhen-Xing Zhu Yu Liu Shao-Jun Liu Chuan-Zao Mao Yun-Rong Wu Ping Wu | 2012 | Molecular Plant2012，5，1： | 30 |
| 10 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 11 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 12 | Effect of dietary supplementation with mulberry(Morus alba L.) leaves on the growth performance,meat quality and antioxidative capacity of finishing pigs显示文摘The present study was conducted to evaluate the effect of dietary mulberry(Morus alba L.) leaves powder(MLP) supplementation on meat quality of finishing pigs.A total of 40 Duroc×Landrace×Yorkshire pigs(initial body weight of(40.5±0.63) kg) were randomly allotted into two treatments,fed either with control diet or 15% MLP diet for 85 d.The results showed that MLP diet decreased(P≤0.05) average daily gain(ADG) and increased(P<0.05) feed/gain ratio(F/G) in the finishing and whole period.MLP diet also decreased(P<0.05) carcass weight,dressing percentage,last rib and average backfat depth.However,MLP diet increased(P<0.05) intramuscular fat(IMF) content,decreased(P<0.05) shear force,cooking loss and drip loss.In addition,MLP diet increased(P<0.05) total antioxidative capacity,glutathione peroxidase and tended(P<0.10) to increase total superoxide dismutase in serum.In longissimus thoracis,myosin heavy chain(MyHC) I and IIa mRNA levels were increased(P≤0.05) for MLP diet.In conclusion,15% MLP supplementation reduced the growth performance and carcass traits,but improved meat quality of finishing pigs possibly through the change of myofiber characteristics,enhancement of antioxidative capacity and increase of IMF. | ZENG Zhu JIANG Jun-jie YU Jie MAO Xiang-bing YU Bing CHEN Dai-wen | 2019 | Journal of Integrative Agriculture2019，18，1： | 24 |
| 13 | Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells显示文摘AIM: To study the capacity of bone marrow mesenchymal stem cells (BM-MSCs) trans-differentiating into islet-like cells and to observe the effect of portal vein transplantation of islet-like cells in the treatment of streptozotocin-induced diabetic rat. METHODS: BM-MSCs were isolated from SD rats and induced to differentiate into islet-like cells under defined conditions. Differentiation was evaluated with electron microscopy, RT-PCR, immunofluorescence and flow cytometry. insulin release after glucose challenge was tested with ELiSA. Then allogeneic islet-like cells were transplanted into diabetic rats via portal vein. Blood glucose levels were monitored and islet hormones were detected in the liver and pancreas of the recipient by immunohistochemistry. RESULTS: BM-MSCs were spheroid adherent monolayers with high CD90, CD29 and very low CD45 expression. Typical islet-like cells clusters were formed after induction. Electron microscopy revealed that secretory granules were densely packed within the cytoplasm of the differentiated cells. The spheroid cells expressed islet related genes and hormones. The insulin-positive cells accounted for 19.8% and mean fluorescence intensity increased by 2.6 fold after induction. The cells secreted a small amount of insulin that was increased 1.5 fold after glucose challenge. After transplantation, islet-like cells could locate in the liver expressing islet hormones and lower the glucose levels of diabetic rats during d 6 to d 20.CONCLUSION: Rat BM-MSCs could be transdifferentiated into islet-like cells in vitro . Portal vein transplantation of islet-like cells could alleviate the hyperglycemia of diabetic rats. | Xiao-Hong Wu Cui-Ping Liu Kuan-Feng Xu Xiao-Dong Mao Jian Zhu Jing-Jing Jiang Dai Cui Mei Zhang Yu Xu Chao Liu | 2007 | World Journal of Gastroenterology2007，13，24： | 23 |
| 14 | Successfully managing a rapidly growing peritoneal dialysis program in Southern China显示文摘背景有限资源的最大的使用改进腹分离( PD )穿入和临床的结果是为所有 PD centers.In 的挑战这研究,我们在成功地在南部的 China.Methods 管理一个很快成长的 PD 中心报导了经验和结果与一个队一起的一个标准 PD 节目由 6 nephrologists 组成了( 3 位医生负责导管插入,住院病人关心,另外的 3 位医生集中了于 PD 病人的后续和教育)并且在 PD 的 11 | YANG Xiao MAO Hai-ping GUO Qun-ying YU Xue-qing | 2011 | Chinese Medical Journal2011，，17： | 22 |
| 15 | TANDEM and GMAW Twin Wire Welding of Q690 Steel Used in Hydraulic Support显示文摘Compared with using semi-automatic gas shielded arc welding, using automatic TANDEM twin wire welding and twin wire gas metal arc welding (GMAW) to weld Q690 steel, a low-alloy high-strength structural steel used in the hydraulic support in the fully-mechanized mining face, the welding speed, deposition rate, production environment and welding quality can be obviously improved. Compared with GMAW twin wire welding, a refined microstructure in the weld and heat-affected zone (HAZ), narrow HAZ and improved joint strength were achieved with TANDEM on Q690. Also, due to the push-pull pulsed way in TANDEM welding, the droplet transfer, distribution on heat flow and interaction between two arcs were completely different from those in GMAW twin wire system. The heat input of TANDEM is only about 76.6% of GMAW, and correspondingly, the welding speed and welding seam can be obviously improved. The complete oscillation caused by TANDEM pulsed current occurred in the welding pool, which refined the grains in the microstructure. The results show that TANDEM twin wire welding is very suitable in the welding of Q690 used in the hydraulic support. | FANG Chen-fu MENG Xiao-hui HU Qing-xian WANG Feng-jiang REN He WANG Hai-song GUO Yu MAO Ming | 2012 | Journal of Iron and Steel Research(International)2012，19，5： | 22 |
| 16 | Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression显示文摘长期的 periodontitis (CP ) 是最普通的口头的疾病之一,它在成年人引起牙槽的骨头吸收和牙齿损失。在我们试图调查 plumbagin (PL ) 的潜力的这研究,广泛地调查的活跃混合物在对待 CP 从繁体中文植物石墨 zeylanica L 提取了。人的牙齿周围的系带干细胞(PDLSC ) 在 vitro 被用于研究,而 CP 的一个动物模型被 ligation+Porphyromonas gingivalis (Pg ) 在 SD 老鼠建立刺激。老鼠与 PL 被注射(2, 4,和 6 mgs。在这研究,我们建立了 biomarkers 的焦点模式描绘 Gegen Qinlian 煎(GQD ) 的剂量效果关系,为对待类型 2 糖尿病 mellitus (2-DM ) 的一个 TCM 公式。2-DM 的一个老鼠模型通过喂的饮食与低剂量的 STZ 注射相结合的高脂肪被建立。有 2-DM 的老鼠是管理高度,中间或低剂量(6.785, 4.071, 1.357 mgl/L ) 在 vitro 引起了 glomerular podocyte apoptosis,它被无毒的 chrysin (1-20 mol/L ) dose-dependently 通过 DNA 的减小稀释破碎。Chrysin 处理 dose-dependently 恢复了增加的 Bax/Bcl-2 比率,并且在高暴露葡萄糖的肾的 podocytes 压制了 Apaf-1 正式就职和提高的细胞色素 c 版本。在糖尿病的 db/db 老鼠, chrysin 的口头的管理(10 mgf 1.84 ??? ?? | Xin-yi ZHENG Chuan-yuan MAO Han QIAO Xi ZHANG Li YU Ting-yu WANG Er-yi LU | 2017 | Acta Pharmacologica Sinica2017，38，8： | 22 |
| 17 | MADS-Box Transcription Factor AGL21 Regulates Lateral Root Development and Responds to Multiple External and Physiological Signals显示文摘植物根系统形态学被各种各样的环境暗示戏剧性地影响。到环境限制的根系统建筑学的改编,主要取决于侧面的根的形成和生长,是一个重要农学的特点。侧面的根开发被与内在的发信号的小径仔细协调的外部信号调整。疯盒子的抄写因素是到 flowering 和花开发的转变的已知的关键管理者。然而,他们在根开发的功能仍然糟糕被理解。这里,我们报导那 AGL21, AGL17-clade 疯盒子的基因,在侧面的根开发起一个关键作用。AGL21 高度在根被表示,特别地在根中央柱体和侧面的根 primordia。当 agl21 异种显示出损害的侧面的根开发时, AGL21 overexpression 植物生产了更多和更长侧面的根,特别在氮缺乏的条件下面。AGL21 被许多植物荷尔蒙和环境压力导致,建议在响应各种各样的信号的根系统粘性的这基因的一个函数。而且, AGL21 断然被发现由提高本地植物生长素生合成,因此刺激的侧面的根开始和生长在侧面的根 primordia 和侧面的根调整植物生长素累积。我们建议 AGL21 可以涉及各种各样的环境、生理的调停信号的侧面的根开发和生长。 | Lin-Hui Yu Zi-Qing Miao Guo-Feng Qi Jie Wu Xiao-Teng Cai Jie-Li Mao Cheng-Bin Xiang | 2014 | Molecular Plant2014，7，11： | 21 |
| 18 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 19 | NIR-induced highly sensitive detection of latent finger- marks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state显示文摘通常在犯罪场面发现 fingermarks 的大多数是潜伏的并且,这样为检测潜伏的 fingermarks 的一个有效方法是很重要的。然而,传统的发展中技术有象低察觉敏感,高背景干扰,复杂操作,和高毒性那样的缺点。处理这挑战,我们采用了荧光灯 NaYF 4:Yb,Er upconversion nanoparticles (UCNP ) 它能发荧光可见的光什么时候由 980 nm 使对人安全的在红外线附近的光激动,到污点,各种各样的底层上的潜伏的 fingermarks 出现。 UCNP 成功地被用作一篇小说荧光灯为有包括非渗入的材料(玻璃,大理石,铝合金表,不锈钢表,铝陪衬,和塑料卡片)的各种各样的底层上的高敏感,低背景,高效率,和低毒性的潜伏的 fingermarks 的察觉的标签,渗入半的材料(地板皮革,陶器的瓦,木头地板,和油漆木头),和象报纸的各种各样的类型那样的渗透的材料。这个工作证明 UCNP 是一万用荧光灯为几乎任何东西上的 fingermarks 的灵巧的察觉的标签材料,在法庭的科学启用他们的实际应用。 | Meng Wang Ming Li Mingying Yang Xiaomei Zhang Aoyang Yu Ye Zhu Penghe Qiu Chuanbin Mao | 2015 | Nano Research2015，8，6： | 20 |
| 20 | Study of the ionospheric anomaly before the Wenchuan earthquake显示文摘The behavior of the ionosphere before the Wenchuan earthquake is analyzed with the global TEC and ionospheric foF2 observed at Xiamen. It can be found from TEC maps that in the afternoon (16―18LT) on May 9, 2008, 3 days before the earthquake, there is an enhancement of TEC with an amplitude of 10―15 TECU appearing in the east-south direction of Wenchuan, and another enhancement appears at the conjugate region of the Southern Hemisphere with an amplitude of 10 TECU, but no obvious in-crement or decrement can be seen in other regions on global scale. It can also be found that on May 6 (6 days before the great earthquake), there is a decrement of TEC with small amplitude of 4TECU and larger area with 80° along the longitude in southern China, and there is no synchronous decrement observed at the conjugate region of the Southern Hemisphere. There are also many anomalies ob-served by ionosondes across China. The result shows that foF2 and TEC abnormally increased, which is different from pervious results that ionospheric parameters decreased prior to earthquakes. Pre-liminary results suggest that the enhancement on May 9 maybe has a close relationship with the pos-sible enhancement of ionospheric electric fields, and it may be an ionospheric precursor of earth-quakes. Whereas the decrement on May 6 may be attributed to the geomagnetic disturbance appearing on May 5. | YU Tao MAO Tian WANG YunGang WANG JingSong | 2009 | Chinese Science Bulletin2009，54，6： | 20 |
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