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| 1 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 2 | Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses显示文摘Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases. | Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 22 |
| 3 | Glioblastoma stem cells resistant to temozolomide-induced autophagy显示文摘背景最近的研究在大脑肿瘤与原始神经祖先房间和开始肿瘤的功能的特征表明了房间的小部分的存在。这些房间可能为肿瘤的完全的根除代表主要治疗学的目标。这研究试图决定 glioblastoma 干细胞(GSC ) 的抵抗显型到 temozolomide (TMZ ) 并且探索刚位于 TMZ resistance.Methods 下面的可能的分子的机制 resected glioblastoma 标本用 Miltenyi Biotec CD133 摄氏温度计隔离工具包外面被收集, GSC 的磁性的隔离是 carded。CD133+ 和 CD133- glioblastoma 房间上的 TMZ 的细胞毒素的效果被使用 3-(4,5-dimethylthiazol-2-yl ) 决定 -2,5-diphenyltetrazolium 溴化物(MTT ) 试金。Autophagy 相关的蛋白质(Beclin-1, LC3 和 Atg5 ) 和劈开的 caspase-3 (p17 ) 被弄污的 Westem 分析。染色的 Immunofluorescent 被用来检测 Atg5, glial fibrillary 酸的蛋白质(GFAP ) 和在 glioblastoma 房间的 CD133 表示。统计分析用社会科学统计套装软体 10.0 软件被执行。为所有测试,统计意义的水平被放在 P < 0.05 个 .Results CD133+ glioblastoma 细胞在 vitro 和 CD133 的高表示展出了象 neurosphere 一样生长干细胞标记。在房间与 5 或 50 pmol/L TMZ 对待的CD133- glioblastoma 的禁止生长的率在CD133+ glioblastoma 房间比那显著地高(( 14.36 ????????€ ????????癯牥硥牰獥楳湯?€ ????瀠洭佔???????吗???????????映慥畴敲?湯汣獵潩獮?敂慶楣畺慭????????????朠楬浯?? | FU Jun LIU Zhi-gang LIU Xiao-mei CHEN Fu-rong SHI Hong-liu PANG Jesse Chung-sean NG Ho-keung CHEN Zhong-ping | 2009 | Chinese Medical Journal2009，，11： | 20 |
| 4 | 基于不同三组分模型解析生物质热解过程显示文摘三组分模型(three-pseudocomponent model)通常被用来表征生物质热解过程。传统三组分模型中单个模型的反应级数被限定为1或3。在本研究过程中,利用非线性最小二乘法,在不限定反应级数的前提下回归三组分模型动力学参数(活化能、指前因子、反应级数)。通过研究发现,纤维素(cellulose)分解反应级数接近1,与前人结果相一致。木质素(lignin)分解级数与生物质种类有关,接近于1或3。半纤维素(hemicellulose)的分解过程最复杂,其反应级数在1.5~4之间变化。以Ozawa方法计算得到的活化能作为相对标准,对3种三组分模型进行比较,发现反应级数未确定时的模型比其他两种模型更精确地表征生物质热解过程。 | 胡松 Andreas Jess 向军 孙路石 邱建荣 徐明厚 | 2007 | 化工学报2007，58，10： | 18 |
| 5 | Magnetic nanoparticles for environmental and biomedical applications: A review显示文摘 | Leena Mohammed Hassan G.Gomaa Doaa Ragab Jesse Zhu | 2017 | Particuology2017，15，1： | 16 |
| 6 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 7 | Fluidized-Bed Bioreactor Applications for Biological Wastewater Treatment: A Review of Research and Developments显示文摘污水处理是保护环境和人类健康的重要过程。目前,最经济有效的污水处理方法为生物处理法,如运行时间较长的活性污泥法。然而,随着人口的增长,对新型高效污水处理技术的需求越来越迫切,流态化技术虽然已展示出能够提高许多化学与生化处理过程的效率,但尚未在大型污水处理过程中得到广泛的应用。循环流化床生物反应器(CFBBR)污水处理技术的研究始于加拿大西安大略大学,在该技术中,载体颗粒表面会形成一层含细菌与其他微生物的生物膜,并在反应器中呈流化状态;流态化固有的良好混合和质量传递特性,使得该技术在生活污水和工业污水处理过程中均具优势。实验室阶段和中试阶段的研究均证实了CFBBR可去除污水中90%以上的碳源、80%以上的氮源,且污泥产量少于活性污泥法的1/3。由于该技术的高效性,CFBBR还可被用于传统方法难以处理的高有机碳污水处理,且具有占地面积小的优势。同时,CFBBR在动态负荷试验(进水量和进水浓度变化)中也展现了良好的抗冲击和恢复性能。总的来说,CFBBR是一种高效的污水处理方法,可在较短的水力停留时间和较小的反应器体积内处理更多的污水。此外,该反应器的紧凑设计将有助于在偏僻地区建造独立的污水处理系统。 | Michael J. Nelson George Nakhla Jesse Zhu | 2017 | Engineering2017，3，3： | 14 |
| 8 | 膝关节前交叉韧带损伤及重建后肌肉力量变化的研究显示文摘对ACL陈旧性损伤、急性损伤、手术重建以及未损伤对象四个样本组 ,在等长条件下膝关节肌肉屈伸、旋内 ,旋外、内收和外展的力量情况进行了对比测试。共记录了 5 4个研究对象的 80组测试结果。结果表明各样本组肌肉力量比值在不同方向上存在显著性差异。该结果可能有助于解释ACL损伤及重建后神经肌肉系统的补偿机制 ,并提示通过选择性地训练某些肌肉可达到有效的康复效果。 | 王广志 张立群 Gordon W Nuber Mark K Bowen Jesse Butler | 2000 | 中国运动医学杂志2000，19，4： | 13 |
| 9 | Circulating turbulent fluidization-A new fluidization regime or just a transitional phenomenon显示文摘While circulating fluidized bed(CFB)reactor has many advantages over the more conventional turbulent fluidized bed(TFB)reactor,it does at least have one significant shortcoming-the rather dilute solids volume concentration in CFB reactor gives rise to less ideal reaction intensity.On the other hand,while having higher reaction intensity,TFB reactor has one fatal drawback of particle back-mixing,making it not suitable for certain reactions such as catalytic reaction where the catalyst requires frequent regeneration.This paper describes some key issues in the development of a circulating turbulent fluidized bed(CTFB) reactor that combines the advantages of both TFB and CFB,that is,to have the high reaction intensity as in TFB but and also to have a suppressed solids back-mixing as in CFB due to a continuous net upflow of solids flux through the bed.Experimental results show enough evidence to suggest that a new fluidization regime is formed,the characteristics of which appears to be distinct from those observed in a regular TFB and from those in either the bottom or the upper sections of regular CFB and/or high-density CFB(HDCFB).Fundamentally,the difference is that particle-particle interaction(collision)dominates the motion of particles in CTFB and TFB,while gas-particle interaction(drag force)is the key element that determines the two phase flow in CFB including HDCFB. | Jesse Zhu | 2010 | Particuology2010，8，6： | 12 |
| 10 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 11 | Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies显示文摘 | Tine Jess Christine Rungoe Laurent Peyrin–Biroulet | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 11 |
| 12 | Deep learning analysis of defect and phase evolution during electron beam-induced transformations in WS_(2)显示文摘Recent advances in scanning transmission electron microscopy(STEM)allow the real-time visualization of solid-state transformations in materials,including those induced by an electron beam and temperature,with atomic resolution.However,despite the ever-expanding capabilities for high-resolution data acquisition,the inferred information about kinetics and thermodynamics of the process,and single defect dynamics and interactions is minimal.This is due to the inherent limitations of manual ex situ analysis of the collected volumes of data.To circumvent this problem,we developed a deep-learning framework for dynamic STEM imaging that is trained to find the lattice defects and apply it for mapping solid state reactions and transformations in layered WS_(2).The trained deep-learning model allows extracting thousands of lattice defects from raw STEM data in a matter of seconds,which are then classified into different categories using unsupervised clustering methods.We further expanded our framework to extract parameters of diffusion for sulfur vacancies and analyzed transition probabilities associated with switching between different configurations of defect complexes consisting of Mo dopant and sulfur vacancy,providing insight into pointdefect dynamics and reactions.This approach is universal and its application to beam-induced reactions allows mapping chemical transformation pathways in solids at the atomic level. | Artem Maksov Ondrej Dyck Kai Wang Kai Xiao David B.Geohegan Bobby G.Sumpter Rama K.Vasudevan Stephen Jesse Sergei V.Kalinin Maxim Ziatdinov | 2019 | npj Computational Materials2019，，1： | 11 |
| 13 | Male infertility: lifestyle factors and holistic, complementary, and alternative therapies显示文摘当我们可能与男不孕的一条对症疗法的途径是舒适的时,我们为生活方式修正和被许多我们的病人使用的整体、互补、其他的治疗的知识也负责。这份报纸提供为几这些治疗把事实与小说分开的基于证据的评论。有足够的文学由饮食和锻练支持重量减小,吸停止,和白酒中等。在小使随机化的控制试用(RCT ) 上在男富饶上表明了积极效果的补充包括 aescin,辅酶 Q 10, 谷胱甘肽,朝鲜红人参, L 肉毒碱, nigella sativa, omega-3,硒,锌的联合并且叶酸,并且 Menevit 抗氧化剂。对维生素 C,维生素 E,或藏花的使用没有支持。为中国草药的药的数据,针灸,头脑身体实践,阴囊的冷却,并且基于信心的愈合稀少或不确定。 | David F Yao Jesse N Mills | 2016 | Asian Journal of Andrology2016，18，3： | 11 |
| 14 | 人体颅脑三维有限元模型构建显示文摘根据人体脑部的螺旋CT扫描图像,利用图形处理,三维重建和有限元网络划分技术,建立了一个基于人体解剖学结构的脑部的三维有限元模型。用非规则形体、有限元软件Ansys划分网格。此模型包括大脑左右半球,小脑,脑干,大脑镰,小脑幕,网格细化到平均尺寸6mm,此模型以精确CT数据为依据,为宇航、交通事故、司法鉴定创伤判断、临床治疗提供可用颅脑有限元模型. | 芦俊鹏 张建国 Jesse RUAN 何培 | 2006 | 微计算机信息2006，，08S： | 9 |
| 15 | Dry powder platform for pulmonary drug delivery显示文摘The phenomenon of particle interaction involved in pulmonary drug delivery belongs to a wide variety of disciplines of particle technology, in particular, fluidization. This paper reviews the basic concepts of pulmonary drug delivery with references to fluidization research, in particular, studies on Geldart group C powders. Dry powder inhaler device-formulation combination has been shown to be an effective method for delivering drugs to the lung for treatment of asthma, chronic obstructive pulmonary disease and cystic fibrosis. Even with advanced designs, however, delivery efficiency is still poor mainly due to powder dispersion problems which cause poor lung deposition and high dose variability. Drug particles used in current inhalers must be 1-5 m in diameter for effective deposition in small-diameter airways and alveoli. These powders are very cohesive, have poor flowability, and are difficult to disperse into aerosol due to cohesion arising from van der Waals attraction. These problems are well known in fluidization research, much of which is highly relevant to pulmonary drug delivery. | Derek Ivan Daniher Jesse Zhu | 2008 | Particuology2008，6，4： | 9 |
| 16 | Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction显示文摘The management options for ureteral obstruction are diverse, including retrograde ureteral stent insertion or antegrade nephrostomy placement, with or without eventual antegrade stent insertion. There is currently no consensus on the ideal treatment or treatment pathway for ureteral obstruction owing, in part, to the varied etiologies of obstruction and diversity of institutional practices. Additionally, different clinicians such as internists, urologists, oncologists and radiologists are often involved in the care of patients with ureteral obstruction and may have differing opinions concerning the best management strategy. The purpose of this manuscript was to review available literature that compares percutaneous nephrostomy placement vs ureteral stenting in the management of ureteral obstruction from both benign and malignant etiologies. | Linda Hsu Hanhan Li Daniel Pucheril Moritz Hansen Raymond Littleton James Peabody Jesse Sammon | 2016 | World Journal of Nephrology2016，5，2： | 9 |
| 17 | Risk of infections associated with biological treatment in inflammatory bowel disease显示文摘Tumor necrosis factor-α(TNF-α)inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease,rheumatoid arthritis and psoriasis.The most commonly used TNF-αantagonists are infliximab,adalimumab,and certolizumab pegol,and though highly effective in lowering inflammation,the efficacy must be weighed against the potential for adverse events.The treatment-induced immunosuppression is suspected to increase the risk of infections,including the risk of reactivation of latent tuberculosis,as the TNF-αcytokine plays an important role in the immune function.In this topic highlight a short overview of the infection risk associated with TNF-αinhibiter therapy is outlined with a focus on the overall risk of serious infections,mycobacterial infection and latent viral infections. | Nynne Nyboe Andersen Tine Jess | 2014 | World Journal of Gastroenterology2014，20，43： | 9 |
| 18 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 19 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 20 | Inflammatory bowel disease imaging:current practice andfuture directions显示文摘The purpose of this paper is to evaluate the role of imaging in inflammatory bowel disease(IBD), including detection of extraluminal complications and extraintestinal manifestations of IBD, assessment of disease activity and treatment response, and discrimination of inflammatory from fibrotic strictures. IBD is a chronic idiopathic disease affecting the gastrointestinal tract that is comprised of two separate, but related intestinal disorders; Crohn's disease and ulcerative colitis. The paper discusses, in detail the pros and cons of the different IBD imaging modalities that need to be considered in order to optimize the imaging and clinical evaluation of patients with IBD. Historically, IBD evaluation of the bowel has included imaging to assess the portions of the small bowel that are inaccessible to optical endoscopic visualization. This traditionally was performed using barium fluoroscopic techniques; however, cross-sectional imaging techniques(computed tomography and magnetic resonance imaging) are being increasingly utilized for IBD evaluation because they can simultaneously assess mural and extramural IBD manifestations. Recent advances in imaging technology, that continue to improve the ability of imaging to noninvasively follow disease activity and treatment response, are also discussed. This review article summarizes the current imaging approach in inflammatory bowel disease as well as the role of emerging imaging modalities. | Aoife Kilcoyne Jess L Kaplan Michael S Gee | 2016 | World Journal of Gastroenterology2016，22，3： | 8 |
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