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| 1 | Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term显示文摘条款世袭 Non-Polyposis Colorectal 癌症(HNPCC ) 是林奇描述的症候群的一个差的描述符。在最后十年,条款被用于满足有限临床的标准的家庭的异构的组,例如阿姆斯特丹标准。并非所有阿姆斯特丹标准积极的家庭有 Lynch 症候群,现在是明显的。条款 HNPCC 也被用于有 DNA 微卫星不稳定性的 CRC 在,但是在在哪个没有一个改变的 DNA 失配修理(MMR ) 的垂直传播被诊断,但是在哪个的临床的情形基因。有多重、互相不兼容的意思的一项条款是高度有问题的,特别地当它可以影响一个单个家庭的管理时。Lynch 症候群最好作为遗传素因被理解到恶意被一个细菌线变化在 DNA MMR 基因解释。诊断不在绝对意义取决于任何特别家庭家谱结构或恶意的发作的年龄。有颜色的强壮的家庭历史的家庭没有林奇症候群的表面的癌症作为“家庭 Colorectal 癌症 Type-X ”被组织了。在描绘这些癌症家庭的第一步是把他们与林奇症候群区分开来。术语 HNPCC 不再服务任何有用目的并且应该被逐步停止。 | Jeremy R Jass | 2006 | World Journal of Gastroenterology2006，12，31： | 24 |
| 2 | Artificial intelligence in gastrointestinal endoscopy:The future is almost here显示文摘Artificial intelligence(AI) enables machines to provide unparalleled value in a myriad of industries and applications. In recent years, researchers have harnessed artificial intelligence to analyze large-volume, unstructured medical data and perform clinical tasks, such as the identification of diabetic retinopathy or the diagnosis of cutaneous malignancies. Applications of artificial intelligence techniques, specifically machine learning and more recently deep learning, are beginning to emerge in gastrointestinal endoscopy. The most promising of these efforts have been in computeraided detection and computer-aided diagnosis of colorectal polyps, with recent systems demonstrating high sensitivity and accuracy even when compared to expert human endoscopists. AI has also been utilized to identify gastrointestinal bleeding, to detect areas of inflammation, and even to diagnose certain gastrointestinal infections. Future work in the field should concentrate on creating seamless integration of AI systems with current endoscopy platforms and electronic medical records, developing training modules to teach clinicians how to use AI tools, and determining the best means for regulation and approval of new AI technology. | Muthuraman Alagappan Jeremy R Glissen Brown Yuichi Mori Tyler M Berzin | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 14 |
| 3 | Glucose control in critical care显示文摘Glycemic control among critically-ill patients has been a topic of considerable attention for the past 15 years. An initial focus on the potentially deleterious effects of hyperglycemia led to a series of investigations regarding intensive insulin therapy strategies that targeted tight glycemic control. As knowledge accumulated, the pursuit of tight glycemic control among critically-ill patients came to be seen as counterproductive, and moderate glycemic control came to dominate as the standard practice in intensive care units. In recent years, there has been increased focus on the importance of hypoglycemic episodes, glycemic variability, and premorbid diabetic status as factors that contribute to outcomes among critically-ill patients. This review provides a survey of key studies on glucose control in critical care, and aims to deliver perspective regarding glycemic management among critically-ill patients. | Jeremy Clain Kannan Ramar Salim R Surani | 2015 | World Journal of Diabetes2015，6，9： | 7 |
| 4 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 5 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 6 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 7 | Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions显示文摘Point-of-care(POC) tests enable rapid results and are well established in medical practice.Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways.This review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was performed.Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included.Studies recovered were heterogeneous and therefore results are presented as a narrative review.Six diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical application.POC devices have a proven role in the diagnosis of gastrointestinal cancer.Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow.New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival. | Jeremy R Huddy Melody Z Ni Sheraz R Markar George B Hanna | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 8 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species显示文摘 | Hebert Paul D.N. Ratnasingham Sujeevan de Waard Jeremy R | 2003 | Proceedings of the Royal Society B: Biological Sciences2003，，： | 2 |
| 9 | Biological identifications through DNA barcodes显示文摘 | Hebert Paul D. N. Cywinska Alina Ball Shelley L. deWaard Jeremy R | 2003 | Proceedings of the Royal Society B: Biological Sciences2003，，1512： | 2 |
| 10 | Biological identifications through DNA barcodes显示文摘 | Hebert Paul D. N. Cywinska Alina Ball Shelley L. deWaard Jeremy R | 2003 | Proceedings of the Royal Society B: Biological Sciences . 2003 (1512)2003，，1512： | 2 |
| 11 | Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands 显示文摘 | Jeremy R Graff JR | 1996 | Proc Natl Acad Sci USA1996，93，18： | 1 |
| 12 | An interactive genetic algorithm-based framework for handling qualitative criteria in design optimization显示文摘 | Alexandra M B Jeremy R Ashutosh T | 2007 | Computers in Industry2007，58，： | 1 |
| 13 | Factors influencing bicycle crash severity on two-lane,undivided roadways in north carolina显示文摘 | Jeremy R Klop Asad J Khattak | 1999 | Transportation Research Record1999，，1674： | 1 |
| 14 | The effects of radioactive decay of uranium on elemental and isotopic ratios of Alum shale kerogen 显示文摘 | Jeremy Dahl Rolf Hallberg Kaplan I R | 1988 | Applied Geochemistry1988，3，： | 1 |
| 15 | Effects of irradiation from uranium decay on extractable organic matter in the Alum Shales of Sweden 显示文摘 | Jeremy Dahl Rolf Hallberg Kaplan I R | 1988 | Organic Geochemistry1988，12，： | 1 |
| 16 | Competitive intelligence activity among small firms显示文摘 | Groom Jeremy R Fred R David | 2001 | S AM A dv anced Management Journal2001，661，： | 1 |
| 17 | Nitrogen removal from domestic wastewater using the marshland upwelling system 显示文摘 | Jeremy F Dorin B Kelly A R | 2006 | Ecol Eng2006，27，1： | 1 |
| 18 | Biological identifications through DNA barcodes显示文摘 | Hebert Paul D. N. Cywinska Alina Ball Shelley L. deWaard Jeremy R | 2003 | Proceedings of the Royal Society B: Biological Sciences2003，，1512： | 1 |
| 19 | Ferrate(VI) oxidation ofaqueous cyanide显示文摘 | Virender K S Wayne R Jeremy O S’ | 1998 | Environmental Science & Technology1998，32，17： | 1 |
| 20 | A bioabsorbable (poly- glactin), nonrestrictive, external sheath inhibits porcine saphenous vein graft thickening 显示文摘 | Jeremy JY Bulbulia R Johnson JL | 2004 | J Thorac Cardiovasc Surg2004，127，6： | 1 |
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