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| 1 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Management of biliary tract complications following liver transplantation显示文摘 | Jeffrey GP Brind AM Ormonde DG | 1999 | Aust N Z J Surg1999，69，10： | 1 |
| 3 | White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1:A diffusion tensor imaging study显示文摘 | Jeffrey RW Bryon AM Erin E | | 0，，02： | 1 |
| 4 | Usefulness of high sensitivity C - reactive protein in predicting long - term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction 显示文摘 | James SZ Jeffrey LA Chloe AM | 2002 | Am J Cardiol2002，89，： | 1 |
| 5 | Follow-up strategies after curative resection of colorectal cancer显示文摘 | Jeffrey AM Robert JM | 2003 | Seminars in Oncology2003，30，3： | 1 |
| 6 | White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1:A diffusion tensor imaging study显示文摘 | Jeffrey RW Bryon AM Erin E | 2011 | Neuromuscul Disord2011，21，2： | 1 |
| 7 | Colorectal cancer screening, comorbidity, and follow - up in elderly patients 显示文摘 | Garman KS Jeffreys AM Coffman C | 2006 | American Journal of the Medical Sciences2006，332，： | 1 |
| 8 | SolvophobicaUy driven folding of nonbiological oligomers 显示文摘 | ames C Ndson Jeffery G Saven Jeffrey S Moore | 1997 | Science1997，277，： | 1 |
| 9 | Management of biliary tract complications following liver transplantation 显示文摘 | Jeffrey GP Brind AM Ormonde DG | 1999 | Aust N Z J Surg1999，69，： | 1 |
| 10 | Ajuvant treatment of colorectal cancer 显示文摘 | Brian MW Jeffrey AM Harvey JM | 2007 | CA Cancer J Clin2007，57，： | 1 |
| 11 | Influence of Estrogen and osteopenia/osteoporosis on clinical periodontitis in postmenopausal women显示文摘 | Rechard AR Jeffrey BP Connie AM | 1999 | J Periodontol1999，70，8： | 1 |
| 12 | Assessment of chronic and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin,a quinolone antibiotic显示文摘 | Iatropoulos MJ Jeffrey AM Enzmann HG | 2001 | Exp Toxic Pathol2001，53，5： | 1 |
| 13 | Management of biliary tract complications following liver transplantation 显示文摘 | Jeffrey GP Brind AM Ormonde DG | 1999 | Aust N Z J Surg1999，69，： | 1 |
| 14 | Management of biliary tract complications following liver transplantation显示文摘 | Jeffrey GP Brind AM Ormonde DG | 1999 | Aust N Z J Surg1999，69，10： | 1 |
| 15 | Cortisol increases interstitial collagenase expression in osteoblasts by post- transcriptional mechanisms 显示文摘 | Delany AM Jeffrey JJ Rydziel S | 1995 | J Biol Chem1995，270，26： | 1 |
| 16 | Furan induction of DNA cross-linking and strand breaks in turkey fetal liver in comparison to 1 , 3-propanediol 显示文摘 | Jeffrey AM Brunnemann KD Duan JD | 2012 | Food Chem Toxicol2012，50，34： | 1 |
| 17 | Mouse minisatellite mutations induced by ionizing radiation显示文摘 | Dubrova YE Jeffreys AJ Malashenko AM | 1993 | Nat Genet1993，5，1： | 1 |
| 18 | Follow-up strategies after curative resection of colorectal cancer显示文摘 | Jeffrey AM Robert M | 2003 | Seminars in Oncology2003，30，3： | 1 |
| 19 | Neurological recovery after cranioplasty 显示文摘 | David HS Jeffrey SO Judith AM | 1994 | Neurosurgery1994，34，4： | 1 |
| 20 | The LXR ligand T091317 induces severe lipogenesis in the db/db diabetic mouse显示文摘 | Jeffrey WC Jenny H Scott AM | 2003 | J Lipid Res2003，44，11： | 1 |
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