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| 1 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Status of the contamination in sediments and biota from the western Beaufort Sea(Alaska)显示文摘 | Valette-Silver N Jawed Hameedi M Efurd D W | 1999 | Marine Pollution Bulletin1999，38，8： | 1 |
| 3 | Determinants of Profitability of Banking Sector in India显示文摘 | Majid Karimzadeh Jawed Akhtar S M Behzad Karimzadeh | 2013 | South Asia Paper Transit Stud Rev2013，20，2： | 1 |
| 4 | Performance of anaerobic reactors at low organic load subjected to sudden change in feed substrate types 显示文摘 | Nain M Z Jawed M | 2006 | Journal of Chemical Technology and Biotechnology2006，81，6： | 1 |
| 5 | Probabilistic damage analysis of structures显示文摘 | HWANG H H M JAW J W | 1990 | Journal of Structural Engineering1990，116，7： | 1 |
| 6 | Recycle paper mill trial using enzyme and polymer for upgrading recycled fiber显示文摘 | Sarkar Jawed M | 1997 | Appita J1997，50，1： | 1 |
| 7 | Photoluminescence of InSb, haAs and InAsSb grown by organometallic vapor phase epitaxy显示文摘 | Fang Z M Ma K Y Jaw D H | 1990 | Journal of Applied Physics1990，67，11： | 1 |
| 8 | An update on fat embolism syndrome 显示文摘 | Jawed M Naseem M | 2005 | Pak J Med Sci2005，21，1： | 1 |
| 9 | lmnlobiiization of enzymes on clays and soils 显示文摘 | Jawed M Sarkar Andrzej Leonowicz Jean-Marc Bollag | 1989 | Soil Biology and Biochemistry1989，21，： | 1 |
| 10 | Survival outcomes for multiple myelomaover three decades:a surveillance, epidemiology, and end results (SEER) analysis 显示文摘 | Jawed I Lee C M Tward J D | 2007 | J Clin Oncol2007，25，： | 1 |
| 11 | Requirement Engineering:the Emerging Wisdom显示文摘 | Jawed Siddi Qi Chandra Shekaran M | 1996 | IEEE SoftWare1996，13，2： | 1 |
| 12 | Pneumothorax:a comp lica tion of deep endotracheal tube suction:report of 3 cases显示文摘 | Jaw M C Soong W J Chen S J | 1991 | Zhonghua Yi Xue Za Zhi(Taipei)1991，48，4： | 1 |
| 13 | Predictors of emotional outcomes of intensive care显示文摘 | Rattray JE Johnston M Wildsmith JAW | 2005 | Anaesthesia2005，60，11： | 1 |
| 14 | An update on fat embolism syndrome显示文摘 | Jawed M Naseem M | 2005 | Pak J Med Sci2005，21，： | 1 |
| 15 | Sequence analysis of insecticidal genes from Xenorhabdus nematophilus PMFI296显示文摘 | Morgan JAW Sergeant M Ellis D Ousley M Jarrett P | | 0，，05： | 1 |
| 16 | Probabilistic Damage Analysisof Structures显示文摘 | Hwang H M Jaw J W | 1990 | Journal of Structure Engineering ASCE1990，116，7： | 1 |
| 17 | Requirement Engineering: the emerging wisdom显示文摘 | Jawed SiddiQi M chandra Shekaran | 1996 | IEEE SoftWare1996，13，2： | 1 |
| 18 | Numerical simulation of flow in a screw-type blood pump显示文摘 | Kilani M I Jaw S Y Haik Y | 2005 | Joumal of Visualization2005，8，1： | 1 |
| 19 | Probabilistic Damage Analysisof Structures显示文摘 | Hwang H M Jaw J W | 1990 | Journal of Structure Engineering ASCE1990，116，7： | 1 |
| 20 | Biological costs and benefits to plant - microbe interactions in the rhizosphere 显示文摘 | Jaw M Bending G D White P J | 2005 | Journal of Experimental Botany2005，56，： | 1 |
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