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| 1 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Profile-image method for measuring tunnel profile -improvements and procedures显示文摘 | Wang T T Jaw J J Hsu C H | 2010 | Tunnelling and Underground Space Technology2010，25，： | 1 |
| 3 | M arket orientation: antecedentsand consequences显示文摘 | JAW ORSKI B J K O H L I A K | 1993 | Journal of M arketing1993，57，7： | 1 |
| 4 | The formation of AIN crys- tals in an Fe-Mn-A1-C alloy during the nitriding process显示文摘 | Jaw J H Cheng W C Wang C J | 2005 | Metallurgical and Materials Transactions: A2005，36，9： | 1 |
| 5 | The determinants of new service development:service characteristics,market orientation,and actualizing innovation effort显示文摘 | JAW C LO J Y LIN Y H | | 0，，30： | 1 |
| 6 | The determinants of new service development: service characteristics, market orientation, and actualizing innovation effort 显示文摘 | Jaw C Lo J Y Lin Y H | 2010 | Technovation2010，，30： | 1 |
| 7 | Probabilistic damage analysis of structures显示文摘 | HWANG H H M JAW J W | 1990 | Journal of Structural Engineering1990，116，7： | 1 |
| 8 | Photoluminescence of InSb, haAs and InAsSb grown by organometallic vapor phase epitaxy显示文摘 | Fang Z M Ma K Y Jaw D H | 1990 | Journal of Applied Physics1990，67，11： | 1 |
| 9 | The effect of pyrolysis on the properties of stabilized PAN fabric reinforced phenolic resins for 2D carbon/carbon composites显示文摘 | Ko T H Jaw J J Chen Y C | 1995 | Polym Compos1995，16，： | 1 |
| 10 | 显示文摘 | Tsai H S Jaw G J Chang S H | 2000 | Sur Coatings Tech2000，132，： | 1 |
| 11 | Exercise motivation and process of change in community-dwelling older persons 显示文摘 | Tseng Y H Jaw S P Lin T L | 2003 | Journal of Nursing Research2003，11，4： | 1 |
| 12 | The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution显示文摘 | John EM Jawed H Clinton JD | 2004 | J Neurosci2004，24，7： | 1 |
| 13 | The determinants of new ser- vice development: Service characteristics, market orienta- tion, and actualizing innovation effort显示文摘 | Jaw C Lo J Y Lin Y H | 2010 | Technovation2010，30，4： | 1 |
| 14 | The Determinants of New Service Devel- opment: Service Characteristics, Market Orientation, and Actuali- zing Innovation Effort 显示文摘 | Jaw C Lo J Y Lin Y H | 2010 | Technovation2010，30，4： | 1 |
| 15 | The Determinants of New Service Devel- opment: Service Characteristics, Market Orientation, and Actuali- zing Innovation Effort 显示文摘 | Jaw C Lo J Y Lin Y H | 2010 | Technovation2010，30，： | 1 |
| 16 | Probabilistic Damage Analysisof Structures显示文摘 | Hwang H M Jaw J W | 1990 | Journal of Structure Engineering ASCE1990，116，7： | 1 |
| 17 | A study of aluminum nitride in a Fe-Mn-A1-C alloy显示文摘 | CHENG W C JAW J H WANG C J | 2004 | Scripta Materialia2004，51，4： | 1 |
| 18 | Probabilistic Damage Analysisof Structures显示文摘 | Hwang H M Jaw J W | 1990 | Journal of Structure Engineering ASCE1990，116，7： | 1 |
| 19 | Probability damage analysis of structure 显示文摘 | Hwang H M Jaw J W | 1990 | Journal of Structural Engineering ASCE1990，116，7： | 1 |
| 20 | Probabilistic damage analysis of structures显示文摘 | Hwang H H Jaw J W | 1990 | Journal of Structural Engineering1990，116，7： | 1 |
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