|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 2 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities:the SLIM study显示文摘 | Corpeleijn E Feskens EJ Jansen EH | 2006 | Diabetologia2006，49，10： | 1 |
| 5 | Improvement of Regeneration of Jycopersicon Pennelli Protoplasts by Decreasing Ethylene Production显示文摘 | Jansen C E Snel E A M | 1991 | Plant Cell Report1991，9，： | 1 |
| 6 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 7 | Preparation of thermoset rubber epoxy particles as novel toughening modifiers for glassy epoxy resins显示文摘 | JANSEN B J P TAMMINGA K Y H MEIJER E H | 1999 | Polymer1999，40，20： | 1 |
| 8 | Improvements in glu- cose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activi- ties: the SLIM study 显示文摘 | Corpeleijn E Feskens El Jansen EH | 2006 | Diabetologia2006，49，10： | 1 |
| 9 | Effect of Additives in the Casting Solution on the Formation of PVDF Membranes 显示文摘 | FONTANANOVA E JANSEN J C CRISTIANO A | 2006 | Desalination2006，192，13： | 1 |
| 10 | Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in the Netherlands显示文摘 | Schultsz C Jansen E Keijzers W | 2012 | PLoS One2012，7，33： | 1 |
| 11 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 12 | Epidermal ex-pression of the translation inhibitor programmed celldeath 4 suppresses tumorigenesis显示文摘 | Jansen A P Camalier C E Colburn N H | 2005 | Cancer Res2005，65，14： | 1 |
| 13 | CO2 separation with polyolefin membrane contactors and dedicated absorption liquids:performances and prospects 显示文摘 | Paul H M Feron Albert E Jansen | 2002 | Separation and Purification Technology2002，27，： | 1 |
| 14 | Processing of (in)tractable polymers using reactive solvents V : Morphology control during phase separation 显示文摘 | Jansen B J P Meijer H E H Lemstra P J | 1999 | Polymer1999，40，： | 1 |
| 15 | Possibl origin of nalkanes in high-wax crude oils显示文摘 | Tegelaar E W Matthezing R M Jansen J B H | 1989 | Nature1989，342，： | 1 |
| 16 | As kyphoplan:a program for deformity planning in ankylosing spondylitis显示文摘 | Van Royen BJ Scheerder FJ Jansen E | | 0，，： | 1 |
| 17 | The Founder’s Self-AssessedCompetence and Venture Performance 显示文摘 | Chandler G N and E Jansen | 1992 | Journal of BusinessVenturing1992，7，3： | 1 |
| 18 | Mutation scanning of the p53 tumor suppressor gene in renal and liver transplant patients in Hungary 显示文摘 | Sarvary E Nagy P Benjamin A Szoke M Remport A Jansen J | 2005 | Transpl Proc2005，37，： | 1 |
| 19 | Site-specific integration of Agrobacterium T-DNA in Arabidopsis thaliana mediated by Cre recombinase 显示文摘 | Vergunst A C Jansen L E Hooykaas P J | 1998 | Nucleic Acids Res1998，26，11： | 1 |
| 20 | Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘 | Aronica E Gorter JA Jansen GH | 2003 | Neuroscience2003，118，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员