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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Hostderived proteinases and degradation of dentine collagen in situ显示文摘 | van Strijp AJ Jansen DC DeGroot J ten Cate JM Everts V | 2003 | Caries Res2003，37，： | 1 |
| 4 | Hostderived proteinases and degradation of dentine collagen in situ显示文摘 | van Strijp AJ Jansen DC DeGroot J ten Cate JM Everts V | 2003 | CariesRes2003，37，： | 1 |
| 5 | United States and Indonesian children's and adolescents'reports of relational aggression by dis- liked peers 显示文摘 | French DC Jansen EA Pidada S | 2002 | Child Dev2002，73，4： | 1 |
| 6 | Host-derived proteinases and Degradation of dentine collagen in situ显示文摘 | Van Strijp AJ Jansen DC DeGroot J | | 0，，： | 1 |
| 7 | Conducting Indirect-Treatment- Comparison and Network-Meta-Analysis Studies : Report of ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices : Part 2 显示文摘 | Hoaglin DC Hawkins N Jansen JP | 2011 | Value in Health2011，14，： | 1 |
| 8 | Host - derived proteinases and degradating of dentin collagen in situ 显示文摘 | Van Strijp AJP Jansen DC DeGroot J | 2003 | Caries Res2003，37，1： | 1 |
| 9 | Loss-of- function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs显示文摘 | de Haar SF Jansen DC Schoenmaker T | 2004 | Hum Mutat2004，23，5： | 1 |
| 10 | Host-derived proteinases and degradation of dentine collagen in situ显示文摘 | van Strijp AJ Jansen DC DeGroot J | 2003 | Caries Res2003，37，1： | 1 |
| 11 | Host-derived proteinases and degradating of dentin collagen in situ显示文摘 | Van Strijp AJP Jansen DC De Groot J | 2003 | Caries Res2003，37，1： | 1 |
| 12 | Microassay for the assessment of low levels of hydroxyproline显示文摘 | Creemers LB Jansen DC van Veen-Reurings A | 1997 | Biotechniques1997，22，4： | 1 |
| 13 | Conducting indirect-treatment-comparison and network-meta-analysis studies:report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices:part 2显示文摘 | Hoaglin DC Hawkins N Jansen JP | 2011 | Value Health2011，14，4： | 1 |
| 14 | Conducting Indirect-Treatment- Comparison and Network-Meta-Analysis Studies: Report of ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices : Part 2 显示文摘 | Hoaglin DC Hawkins N Jansen JP | 2011 | Value in Health2011，14，： | 1 |
| 15 | Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors 显示文摘 | Metz DC Jansen RT | 2008 | Gastroenterology2008，135，5： | 1 |
| 16 | Functional heterogeneity of osteoclasts : matrix metalloproteinases participate inosteoclastic resorption of calvarial bone but not in resorption of long bone显示文摘 | Everts V Korper W Jansen DC | 1999 | FASEB J1999，13，10： | 1 |
| 17 | Host - derived proteinases and degradation of dentine collagen in situ 显示文摘 | Van strip AJ Jansen DC DeGroot J | 2003 | Caries Res2003，37，1： | 1 |
| 18 | Microassay for assessment of low levels of hydroxyproline显示文摘 | Greemers LB Jansen DC van Veen-Reuings A | 1997 | Biotechniques1997，22，4： | 1 |
| 19 | Host-derived proteinases and degradation of dentine collagen in situ显示文摘 | Van Strijp AJ Jansen DC DeGroot J | 2003 | Caries Res2003，37，： | 1 |
| 20 | Conducting indirect-treatment- comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part2 显示文摘 | Hoaglin DC Hawkins N Jansen J P | 2011 | Value in Health2011，14，4： | 1 |
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