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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 3 | Macroporous polyester-covered stent in an experimental abdominal aortic aneurysm model显示文摘 | Soula P Janne d'Othee B Otal P | | 0，，04： | 1 |
| 4 | EGFR mutations in lung cancercorrelation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 5 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | | 0，，5676： | 1 |
| 6 | Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman J A Janne P A | | 0，，10： | 1 |
| 7 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 8 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，5676： | 1 |
| 9 | Chemo-radiotherapy and gefinitib in stage Ⅲ Non-small Cell Lung Cancer:a CALGB stratified phase Ⅱ trial显示文摘 | Ready N Janne P Herndon J | 2006 | J Clin Oncol2006，24，： | 1 |
| 10 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，204，5676： | 1 |
| 11 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib ther apy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，： | 1 |
| 12 | Stabilization of mercury containing sludge by a combined process of 2-stage pretreatment and solidification 显示文摘 | Chang C Y Hsu C P Jann J S | 1993 | Journal of Hazardous Material1993，35，1： | 1 |
| 13 | Highresolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines显示文摘 | Janne P A Li C Zhao X | 2004 | Oncogene2004，23，15： | 1 |
| 14 | Epidermal growth factor receptor mutations in patients with non-small cell lung cancer 显示文摘 | Johnson B E Janne P A | 2005 | Cancer Res2005，65，17： | 1 |
| 15 | Male subfertility induced by acute scrotal beating affects embryo quality in normal female mice显示文摘 | Jannes P | 1998 | Hum Reprod1998，13，2： | 1 |
| 16 | Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridizationpositive/ phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial 显示文摘 | Cappuzzo F Ligorio C Janne P A | 2007 | J Clin Oneol2007，25，16： | 1 |
| 17 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 18 | Aortoduodenal fistula after endovascular stent-graft of an abdominal aortic aneurysm显示文摘 | Janne d'Othee B Soula P Otal P | 2000 | J Vasc Surg2000，31，11： | 1 |
| 19 | Factors underlying sensitivity of cancers to small-molecule kinase inhibitors显示文摘 | JANNE P A GRAY N SETTLEMAN J | 2009 | Nat Rev Drug Discov2009，8，9： | 1 |
| 20 | Optimal set point chasing in dynamic positioning of deep water drilling and intervention vessels显示文摘 | Asgeir J S Bernt L Jann P S Et al | 2001 | Int J Robust Nonlinear Control2001，，11： | 1 |
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