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| 1 | Recurrent postmenopausal bleeding: a prospective cohort study显示文摘 | Paul P. Smith Siobhan O’Connor Janesh Gupta T Justin Clark | 2014 | The Journal of Minimally Invasive Gynecology2014，，： | 1 |
| 2 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K | 2004 | Society for Reproduce and Fertility2004，127，3： | 1 |
| 3 | Levonorgestrel intrauterinesystem versus medical therapy for menorrhagia显示文摘 | JANESH G JOE K LEE M | 2013 | The New England Journal of Medicine2013，，368： | 1 |
| 4 | Endometriosis and the neoplastic process显示文摘 | Varma R Rollason T Janesh K G | 2007 | Reproduction2007，127，3： | 1 |
| 5 | 子宫肌瘤的诊断与管理显示文摘子宫平滑肌瘤(简称子宫肌瘤)是女性最常见的良性肿瘤,可表现为单发或多发,从几毫米到几十厘米或更大,大小不一。据调查,近70%的50岁白人女性及80%以上的50岁黑人女性均可检出至少一个子宫肌瘤。框图1罗列了子宫肌瘤的几种危险因素。症状性肌瘤往往需要手术治疗,造成相当大的医疗费用负担。这篇综述旨在为非专业人士提供关于子宫肌瘤的检查及处理的最新知识。本文也特别描述了当前知识的缺口。 | Mary Ann Lumsden lhraheem Hamoodi Janesh Gupta Martha Hickey 张紫寒 王淑珍 | 2016 | 英国医学杂志中文版2016，19，12： | 1 |
| 6 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K | 2004 | Society for Reproduction and Fertility2004，127，： | 1 |
| 7 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K G | 2004 | Reproduction2004，127，： | 1 |
| 8 | Uterine fibmids: current perspectives显示文摘 | Aamir T Khan Manjeet Shehmar Janesh K Gupta | 2014 | Int J Womens Health2014，6，29： | 1 |
| 9 | Endometriosis and the neoplasticp rocess显示文摘 | Varma R Rollason T Janesh KG | 2004 | Reproduction2004，127，3： | 1 |
| 10 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K | 2004 | Society for Reproduction and Fertility2004，127，： | 1 |
| 11 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K | 2004 | Society for Reproduction and Fertility2004，127，： | 1 |
| 12 | Endometriosis and the neoplastic process显示文摘 | Rajesh V Terrance R Janesh K | 2004 | Society for Reproduce and Fertility2004，127，3： | 1 |
| 13 | Endometriosis and the neoplastic process显示文摘 | Terrance R Janesh K | 2004 | Society for Reproduction and Fertility2004，127，： | 1 |
| 14 | Endometriosis and the neoplastic process显示文摘 | Rajesh Varma Terrance Rollason Janesh K Gupta | 2004 | Reproduction2004，127，3： | 1 |
| 15 | Maternal posture inlabour 显示文摘 | Janesh G Chery N | 2000 | European Journal of Obstetrics& Gynecology and Reproductive Biol-ogy2000，92，2： | 1 |
| 16 | Maternal posture in labour显示文摘 | Janesh Gupta Cheryl Nikodem | | 0，，02： | 1 |
| 17 | Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation显示文摘Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria.On the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line.We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate AMPK.This study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were examined.Treatment with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned medium.These changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and HO-1.Pre-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT assay.Thus,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg effect.Therapeutic response was in the order of:sitagliptin>vildagliptin>exendin-4. | POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR | 2022 | BIOCELL2022，46，12： | 0 |
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