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| 1 | 中国健康人群正常心率范围的调查显示文摘目的 调查中国健康人群心率的分布及其性别、年龄差异 ,评估传统的正常心率标准。方法 采集 5 36 0例 (男 36 14例 ,女 1746例 )健康人心电图 ,并按性别分为 5个年龄组 ,计算各年龄组心率的中位数、上限和下限值。结果 男性心率中位数为 6 7~ 6 8次 /min ,随年龄波动很小 ;女性心率的中位数为 6 7~ 73次 /min ,随年龄增长呈下降趋势。年轻女性心率的中位数、上限和下限值均比同年龄组男性快 5~ 6次 /min ,性别差异随年龄增长而减低或消失。 15 %的人群心率小于 6 0次 /min。男性心率下限值为 5 1次 /min ,而女性心率下限值 5 0岁以前约为 5 5次 /min ,5 0岁以后为 5 1次 /min。男、女心率上限值均随年龄增长逐渐降低 ,但在 5 0岁以后再次增快 ;总体人群的心率上限值为 95次 /min。 | 吴杰 Jan A. Kors Peter R. Rijnbeek 陆再英 徐春芳 Jan H. van Bemmel | 2001 | 中华心血管病杂志2001，29，6： | 36 |
| 2 | Bone Regeneration Based on Tissue Engineering Conceptions – A 21st Century Perspective显示文摘The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades.Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction.However,improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity.Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone.Specifically,novel bioactive(second generation)biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment,whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue.Future generations of biomaterials(third generation)are designed to be not only osteoconductive but also osteoinductive,i.e.to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications.These techniques will lead to novel possibilities for tissue regeneration and repair.At present,tissue engineered constructs that may find future use as bone grafts for complex skeletal defects,whether from post-traumatic,degenerative,neoplastic or congenital/developmental'origin'require osseous reconstruction to ensure structural and functional integrity.Engineering functional bone using combinations of cells,scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties.This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts. | Jan Henkel Maria A.Woodruff Devakara R.Epari Roland Steck Vaida Glatt Ian C.Dickinson Peter F.M.Choong Michael A.Schuetz Dietmar W.Hutmacher | 2013 | Bone Research2013，1，3： | 33 |
| 3 | Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis显示文摘AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis(PSC) and ulcerative colitis(UC).METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with(n = 32) or without(n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16 S ribosomal RNA gene were sequenced on Illumina Mi Seq platform to cover low taxonomic levels. Data were further processed in QIIME employing Ma As Lin and LEf Se tools for analysis of the output data.RESULTS Microbial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease(IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales.CONCLUSION PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes(PSC-IBD and UC). | Lukas Bajer Miloslav Kverka Martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl Julius Spicak Pavel Drastich | 2017 | World Journal of Gastroenterology2017，23，25： | 22 |
| 4 | 中国人群心电图时间参数的年龄和性别差异显示文摘目的 调查和评估中国人群心电图时间参数 (P波和QRS波时限、PR间期、QT及QTc间期 )的年龄和性别差异。方法 采集 5 36 0例 (男 36 14例 ,女 1746例 )健康人心电图并按性别分为5个年龄组 ,计算男、女各年龄组时间参数的平均值、标准差及 96 %范围上、下限。结果 各年龄组男性的P波时限、PR间期以及QRS波时限均大于女性 ,而女性的QTc间期均大于男性 ;各年龄组时间参数的性别差异均具有极显著性 (P <0 0 0 0 1)。男性P波时限和PR间期上限值分别比女性平均长6ms和 12ms;男性QRS波时限上限值为 12 0ms ,女性为 10 9ms ;女性QTc间期上限值比同年龄组男性长16~ 2 0ms,且女性QTc间期 >44 0ms的发生率 (12 8%)明显高于男性 (6 2 %)。除QRS时限外 ,男、女其他时间参数上限值均随年龄增长而增加 ,显示明确的年龄趋势。比较各时间参数年龄组之间差异均具有极显著性 (P <0 0 0 1或P <0 0 0 0 1)。结论 中国人群心电图时间参数存在明显的年龄及性别差异 ,有必要建立与年龄和性别相关的正常值标准。 | 吴杰 Jan A.Kors Peter R. Rijnbeek 陆再英 徐春芳 Jan H.van Bemmel | 2001 | 中华心血管病杂志2001，29，10： | 19 |
| 5 | 中国人群心电图幅度参数的年龄趋势和性别差异的调查显示文摘调查中国人群心电图QRS波幅度参数的年龄趋势和性别差异。采集 5 36 0例 (男 36 14例、女 174 6例 ,年龄范围 18~ 84岁 )健康人 12导联心电图并按性别分为 5个年龄组 ,计算和分析各年龄组男、女R波振幅 ,Sokolow指数(SV1+RV5)和Cornell指数 (RaVL+SV3 )的中位数及 96 %范围的正常上、下限。结果 :Ⅰ和aVL导联的R波振幅随年龄增长显著增加 (P <0 .0 0 1) ,而下壁导联Ⅱ、Ⅲ和aVF的R波振幅随年龄增长一致性地显著降低 (P <0 .0 0 1)。肢体导联R波振幅随年龄的变化与额面QRS电轴随年龄增长逐渐向左 (上 )偏移相一致。在胸导联 ,女性V5导联的R波振幅随年龄增长而增加 ;而男性Sokolow指数随年龄增长而降低。男、女的幅度差别在年轻的人群最为显著 ,随年龄增长这种差别趋向减小。男性Sokolow指数和Cornell指数在各年龄组均显著大于女性 (P <0 .0 0 1)。结论 :心电图幅度参数存在显著的年龄趋势和性别差异 ,确有必要建立与年龄和性别相关的正常值和诊断标准。 | 吴杰 Jan A.Kors Peter R.Rijnbeek 陆再英 徐春芳 | 2002 | 中国心脏起搏与心电生理杂志2002，16，6： | 16 |
| 6 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth显示文摘AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.METHODS: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western blots.RESULTS: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined treatment.CONCLUSION: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus. | Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 7 | Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature显示文摘Xanthogranulomatous 胆汁(XGC ) 是胆囊的破坏煽动性的疾病,很少包含邻近的机关并且模仿国王先进胆囊癌。诊断在病理学的检查以后仅仅通常是可能的。46 42 岁的女人被指我们包含肝核,正确的肝脑叶,恰好结肠的弯曲,和十二指肠的怀疑的胆囊癌症的中心。刷细胞学获得了由内视镜后退胆管造影术(ERC ) 出现了高级发育异常。病人经历了团的在团体切除术,由正确叶切除术,正确的半结肠切除术,和部分十二指肠的切除术组成。出人意料地揭示的病理学的检查一 XGC.Only,为有邻近的机关的直接参与的 XGC 的扩大外科的切除术的六个案例到目前为止被报导了。在这些情况中,与癌给 XGC 的可能的共存,恶意不能被排除,甚至在细胞学和 intraoperative 冰冻切片调查以后。在结论,由于源于在另外的方面上包围机关的高度好攻击的煽动性的侵略的一个方面和可能的复杂并发症上的胆囊癌的差的预后,它似乎这些案例应该被当作恶性瘤直到不那样证明。临床医生们应该包括 XGC 在之中可能微分在肝核群众诊断。 | Antonino Spinelli Guido Schumacher Andreas Pascher Enrique Lopez-Hanninen Hussain Al-Abadi Christoph Benckert Igor M Sauer Johann Pratschke Ulf P Neumann Sven Jonas Jan M Langrehr Peter Neuhaus | 2006 | World Journal of Gastroenterology2006，12，14： | 13 |
| 8 | 加强流行病学中观察性研究报告质量(STROBE)声明:观察性研究报告规范显示文摘很多生物医学研究都是观察性的。但对这类研究的报告却通常不完整,从而限制了对其优缺点及普适性的评价。“加强流行病学中观察性研究报告质量(STROBE)”工作组针对一篇完整明确的观察性研究报告应包括的内容提供了一套建议。建议涵盖了流行病学研究的三种主要设计类型:队列设计、病例对照设计和横断面设计。2004年9月,我们召开了为期2天的研讨会,与会的方法学专家、研究人员和期刊编辑共同起草了一份观察性研究报告应纳入的条目清单草案。此后,又通过协调小组数次会议及与有关人员电子邮件讨论等对该草案进行了修改,纳入了经验性证据和方法学方面的意见。通过研讨会及之后反复的咨询和修订,我们制定出了一个包含22个条目的清单(STROBE声明),分为论文的题目、摘要、引言、方法、结果和讨论等部分。其中18个条目适用于所有三种主要的观察性研究设计,其余4个条目则专门用于队列、病例一对照或横断面设计。详细的解释和示范文件已另行发表,在《公共科学图书馆一医学》(PLoS Medicine)、《内科学年报》(Annalsof Internal Medicine)和《流行病学》(Epidemiology)的网站可以免费获得。我们希望STROBE声明能有助于改善观察性研究报告的质量。 | Erikvon Elm Douglas G Altman Matthias Egger Stuart J Pocock Peter C G tzsche Jan P Vandenbroucke 赵乐(译) 邹光勇(审) 杜怀东(审) | 2008 | 世界临床医学2008，2，1： | 12 |
| 9 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 10 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 11 | 中国人群心电图T波参数正常范围的调查显示文摘调查和评估中国人群 12导联心电图T波参数的正常范围以及年龄、性别和导联差异。采集 5 36 0例 (男 36 14例、女 174 6例 ,年龄范围 18~ 84岁 )健康人 12导联心电图 ,分别按性别分为 5个年龄组 ,计算男、女各年龄组T波幅度和额面T波电轴的中位数及 96 %范围正常上、下限 ,以及各导联负向T波的发生率。结果 :男性各导联T波幅度随年龄增长而逐渐下降 ,呈现明确的年龄趋势 ,尤其在胸导联 (P <0 .0 0 1) ;而女性的年龄趋势并不十分明确。男、女T波振幅的性别差异主要发生在胸导联 (P <0 .0 0 1) ,且T波幅度的性别差异随年龄增长趋向减小。在肢体导联 ,T波振幅的正常上限值在男性为 0 .5 4mV ,女性为 0 .4 5mV ;而在胸导联 ,男性为 1.4 4mV ,女性为 0 .9mV。绝大多数导联女性负向T波发生率高于男性 ;在Ⅰ、Ⅱ及V4~V6导联 ,负向T波最大发生率不超过 1.6 4 % ;在V1导联 ,男性负向T波发生率为 12 .19% ,而女性为 4 6 .79% ;在V2 导联 ,男、女负向T波发生率分别仅为 0 .33%和 2 .4 %。男、女T波中位数电轴均随年龄增长逐渐向左上偏移 ,6 0岁以后又转向左下 ;各年龄组T波中位数电轴的性别差异几乎相同 ,均约为 6°(P <0 .0 0 1)。结论 :中国人群心电图T波参数存在明确的年龄、性别和导联差异。有必要制定与年龄? | 徐春芳 吴杰 陆再英 Jan A.Kors Peter R.Rijnbeek G.van Herpen | 2004 | 中国心脏起搏与心电生理杂志2004，18，5： | 10 |
| 12 | 针对脑卒中的ICF核心分类模板显示文摘目的通过循证和专家讨论研究法建立第一版针对脑卒中的一套综合ICF核心分类模板和与之相应的简明ICF核心分类模板。方法来自于不同国家和地区的国际专家从初步研究中搜集证据,结合这些证据进行正式的决策并最终达成共识。初步研究包括Delphi研究方法、对ICF分类的系统评价以及实证数据的收集。结果来自12个不同国家的39位专家出席会议并达成共识。专家初步研究决定在ICF分类的第二、第三和第四级水平上针对脑卒中确定一套448个类目的ICF核心分类摸板,其中193项类目属于身体功能,26项属于身体结构,165项属于活动和参与,64项属于环境因素。综合性ICF核心分类模板包括在ICF分类第二级水平上的130个类目,其中41项属于'身体功能',5项属于'身体结构',51项属于'活动和参与',33项属于'环境因素'。简明型ICF核心分类模板包括在ICF分类第二级水平上的18个类目,其中6项属于身体功能,2项属于身体结构,7项属于活动参与,以及3项属于环境因素。结论专家组通过整合研究过程中的证据,以及专家们基于ICF框架和分类的观点达成正式的共识,并确定针对'脑卒中'的ICF核心分类模板,同时界定综合型ICF核心分类模板和简要型ICF核心分类模板。 | Szilvia GEYH Alarcos CIEZA Jan SCHOUTEN Hugh DICKSON Peter FROMMELT Zaliha OMAR Nenad KOSTANJSEK Haim RING Gerold STUCKI 张君梅(译) 蔡飞鸣(译) 王朴(译) 邱卓英(审校) 吴弦光(审校) | 2008 | 中国康复理论与实践2008，14，12： | 9 |
| 13 | 基于TerraSAR-X强度图像相关法测量三峡树坪滑坡时空形变显示文摘三峡工程蓄水之后,有可能引起两岸滑坡的发生。本文以三峡库区树坪为研究区域,对不同时相的TerraSAR-X的强度图进行相关计算,求解出2009年2月至2009年10月期间发生的滑坡位移场时空演化。结果表明,在滑坡发生的前几个月,累积变形量很小;在滑坡发生的两三个月当中,变形量比较大,平均位移达到51cm;之后的几个月中,变形量又恢复到平静期的数值,与布设在该区的位移伸缩计结果一致。从本文的研究可以看出,该方法不仅能计算出滑坡引起的形变场,而且能探测地面形变的早期信号,可以用它作为三峡库区未来滑坡监测的重要技术手段。 | 李小凡 MULLER Jan Peter 方晨 赵永红 | 2011 | 岩石学报2011，27，12： | 8 |
| 14 | 正常人额面QRS电轴的年龄趋势以及对肢体导联QRS波振幅的影响显示文摘目的调查和评估正常人额面QRS电轴的年龄趋势以及对肢体导联QRS波振幅的影响。方法采集5360例(男性3614例、女性1746例,年龄范围18~84岁)正常健康人12导联心电图分为5个年龄组,计算和分析各年龄组额面QRS电轴的中位数以及肢体导联QRS波振幅的中位数和96%的正常范围上、下限。结果随年龄增长,男、女额面QRS中位数电轴一致性地逐渐向左(上)偏移大约27°(从70°偏移到43°,P<0.001)。Ⅰ和aVL导联的R波振幅随年龄增长显著增加(P<0.001),而下壁导联Ⅱ、Ⅲ和aVF的R波振幅随年龄增长显著降低(P>0.001)。肢体导联R波振幅随年龄的变化趋势与额面QRS电轴的年龄趋势相一致。结论正常人额面QRS电轴随年龄增长逐渐向左(上)偏移,呈现明确的年龄趋势。QRS电轴的生理性演变可引起肢体导联QRS波振幅呈现明显的年龄差异。显然,把一个相同的左心室肥大心电图诊断标准应用到不同年龄组人群是不合适的。 | 吴杰 Jan A Kors Peter R Rijnbeek Gerard van Herpen 徐春芳 陆再英 | 2006 | 中华心律失常学杂志2006，10，3： | 8 |
| 15 | Association between hepatitis B and metabolic syndrome:Current state of the art显示文摘Chronic hepatitis B(CHB)is a global health issue that increases the risk of liver cirrhosis and hepatocellular carcinoma in infected patients.Metabolic syndrome(Met S)is a disease endemic mostly to the developed countries.It is associated with high cardiovascular mortality and morbidity,diabetes mellitus as well as cancer.In this manuscript,we systematically review the published data on the relationship between Met S and CHB infection.Multiple studies have described highly variable correlations between CHB on one hand and Met S,non-alcoholic fatty liver disease and dyslipidemia on the other.No association between CHB and diabetes mellitus or atherosclerosis has been described as of now.The presence of Met S in patients infected with hepatitis B virus increases the risk of fibrosis,cirrhosis and hepatocellular carcinoma.Appropriate lifestyle,but also pharmacological interventions are needed to prevent the development of these complications. | Peter Jarcuska Sylvia Drazilova Jan Fedacko Daniel Pella Martin Janicko | 2016 | World Journal of Gastroenterology2016，22，1： | 8 |
| 16 | Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells显示文摘Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells(MSC) to secrete brain-derived neurotrophic factor(BDNF) supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington's disease(HD). There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis(ALS), spinocerebellar ataxia(SCA), Alzheimer's disease, and some forms of Parkinson's disease. The MSC/BDNF product could also be considered for studies of regeneration in traumatic brain injury, spinal cord and peripheral nerve injury. This work also provides a platform for our future gene editing studies, since we will again use MSCs to deliver the needed molecules into the central nervous system. | Peter Deng Audrey Torrest Kari Pollock Heather Dahlenburg Geralyn Annett Jan A.Nolta Kyle D.Fink | 2016 | Neural Regeneration Research2016，11，5： | 7 |
| 17 | 成人健康人群心电图正常范围的调查显示文摘目的调查和评估我国成人健康人群心电图的正常范围。方法采集5360例(男性3614例,女性1746例,年龄范围18~84岁)健康人12导联同步心电图并按性别分为5个年龄组,计算和分析男、女各年龄组心电图参数的中位数及96%范围的正常上、下限,并比较其年龄和性别差异。结果PR间期、QTc间期、额面QRS电轴呈现明确的年龄趋势(P〈0.001)。PR间期、QRS波时限、QTc间期及不同导联QRS波和T波振幅存在明显的性别差异(P〈0.001)。男性PR间期上限值约为200ms,女性PR间期上限值从180ms随年龄增长逐渐增加到200ms。男性QRS波时限上限值为120ms,女性为109ms。各年龄组男、女性QTc间期上限值均〉440ms,女性QTc间期〉440ms的发生率(12.8%)明显高于男性(6.2%)。男性QRS电轴的正常范围为-37°~+94°,女性为-27°~+91°.Q波时限正常范围有明确的导联依赖性。在胸前导联,男性T波幅度的正常值不超过1.44mV,女性不超过0.9mV;在肢体导联,男性不超过0.54mV,女性不超过0.45mV。值得注意的是,肢体导联QRS振幅随年龄增长的变化规律与额面QRS电轴随年龄增长逐渐向左(上)偏移相一致;女性V,导联的R波振幅随年龄增长而增加。结论我国成人健康人群心电图参数存在明显的年龄及性别差异,适当调整传统的正常标准,可望进一步提高心电图诊断的质量。 | 吴杰 汪道文 陆再英 徐春芳 Jan A. Kors Peter R. Rijnbeek G. van Herpen | 2008 | 中华心律失常学杂志2008，12，3： | 7 |
| 18 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 19 | Tree diversity and nectar composition affect arthropod visitors on extrafloral nectaries in a diversity experiment显示文摘Aims Plants with extrafloral nectaries(EFNs)are common in tropical and subtropical habitats and,despite many other arthropods also forage for EFN,most studies solely focused on the defense mutualisms between EFN plants and ants.This study aims at a quantitative assessment of the entire arthropod community that visits EFN trees to compare visitor communities between different tree species to disentangle the mechanisms that may drive EFN visitor community composition.We also test for tree diversity effects on EFN visitors,as it is unknown if local tree species richness relates to the abundance and species richness of arthropods foraging for EFN.Methods We sampled EFN-visiting arthropods in the experimental tree species richness gradient of the BEF-China Experiment,the currently largest forest diversity experiment in the world,and tested if tree species richness affects EFN visitors and if visitor community composition differs between EFN tree species.In a second step,we analyzed the EFN of Ailanthus altissima and Triadica cochinchinensis,the two EFN tree species with highest visitor abundance,for sugars and amino acids(AA)to test if tree species-specific differences in nectar chemistry translate to differing visitor communities.Lastly,we conducted a choice experiment using different artificial nectar solutions to test if nectar quality affects foraging decisions of ants,the most frequent EFN visitors in our study sites.Important Findings EFN trees in young successional forests in subtropical South-East China are visited by a diverse assemblage of arthropods including ants,beetles,flies,and spiders.Albeit ants accounted for about 75%of all individuals,non-ant visitors were by far more species rich.Visitor abundance and species richness declined with increasing tree species richness,suggesting a resource dilution effect,because plots with more tree species had proportionally less EFN tree individuals and thus lower nectar availability.Ailanthus altissima and T.cochinchinensis were visited by different arthropods and their nectar had species-specific AA composition and sugar concentration,indicating that differences in visitors may,at least partly,be explained by differences in nectar chemistry.These findings are supported by the choice experiment,in which artificial nectars containing sugar solutions supplemented with essential AAs attracted more ants than pure sugar solutions or sugar solutions supplemented with non-essential AAs.Our results improve the understanding of the complex ecology of EFN trees,a plant life form that might be crucial for understanding how tree diversity influences patterns of tree growth in young successional tropical and subtropical forests. | Michael Staab Joel Methorst Jan Peters Nico Blüthgen Alexandra-Maria Klein | 2017 | Journal of Plant Ecology2017，10，1： | 6 |
| 20 | 美国国家卒中协会短暂性脑缺血发作处理指南显示文摘目的:短暂性脑缺血发作(TIA)是常见和重要的卒中先兆。其处理方法多样,大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法:根据一种客观标准(可以预测在该研究领域中执业医师对专家提名的文献测量学方法)挑选出15名专家组成员。通过系统回顾检索到过去发表的指南,由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见,然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订,从而对新的修改达成共识。给专家们提供近期临床研究的系统评价,要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果:通过系统回顾检索到257个指南,其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论:对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的,考虑到了快速更新并能减少偏倚。 | S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle Peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra Peter M. Rothwell Harold P. Adams Gregory W. Albers 李海峰(译) | 2007 | 国际脑血管病杂志2007，15，3： | 5 |
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