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| 1 | Monopoly power and distribution in framented markets: The case of groundwater显示文摘 | Jacoby H Murgai R Rehman S | 2004 | Review of Economic Studies2004，71，： | 1 |
| 2 | Access to markets and the benefits of rural roads : a nonparametric approach 显示文摘 | Jacoby H G | 2001 | The Economic Journal2001，110，4： | 1 |
| 3 | The radiologic diagno- sis of quadriceps twndon rupture显示文摘 | Spector ED DiMm'cangelo MT Jacoby J H | 1995 | N J Med1995，92，： | 1 |
| 4 | Atherogenesis in swine fed several types of lipid-cholesterol diets显示文摘 | Goldsmith DJ Jacobi H | 1978 | Lipids1978，13，3： | 1 |
| 5 | Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes显示文摘BACKGROUND Cigarette smoking(CS)is the most common method of consuming tobacco.Deleterious effects on bone integrity,increased incidence of fractures,and delayed fracture healing are all associated with CS.Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and,via the bloodstream,reach the skeletal system.New technologies designed to develop a reduced-risk alternative for smokers are based on electronic nicotine delivery systems,such as e-cigarettes and tobacco heating systems(THS).THS are designed to heat tobacco instead of burning it,thereby reducing the levels of harmful toxic compounds released.AIM To examine the effects of THS on osteoprogenitor cell viability and function compared to conventional CS.METHODS Human immortalized mesenchymal stem cells(n=3)and primary human preosteoblasts isolated from cancellous bone samples from BG Unfall Klinik Tübingen(n=5)were osteogenically differentiated in vitro with aqueous extracts generated from either the THS 2.4“IQOS”or conventional“Marlboro”cigarettes for up to 21 d.Cell viability was analyzed using resazurin conversion assay(mitochondrial activity)and calcein-AM staining(esterase activity).Osteogenic differentiation and bone cell function were evaluated using alkaline phosphatase(AP)activity,while matrix formation was analyzed through alizarin red staining.Primary cilia structure was examined by acetylatedα-tubulin immunofluorescent staining.Free radical production was evaluated with 2’,7’-dichlorofluoresceindiacetate assay.RESULTS Our data clearly show that THS is significantly less toxic to bone cells than CS when analyzed by mitochondrial and esterase activity(P<0.001).No significant differences in cytotoxicity between the diverse flavors of THS were observed.Harmful effects from THS on bone cell function were observed only at very high,non-physiological concentrations.In contrast,extracts from conventional cigarettes significantly reduced the AP activity(by two-fold)and matrix mineralization(four-fold)at low concentrations.Additionally,morphologic analysis of primary cilia revealed no significant changes in the length of the organelle involved in osteogenesis of osteoprogenitor cells,nor in the number of ciliated cells following THS treatment.Assessment of free radical production demonstrated that THS induced significantly less oxidative stress than conventional CS in osteoprogenitor cells.CONCLUSIONTHS was significantly less harmful to osteoprogenitor cells during osteogenesisthan conventional CS. Additional studies are required to confirm whether THS isa better alternative for smokers to improve delays in bone healing followingfracture. | Romina H Aspera-Werz Sabrina Ehnert Monja Müller Sheng Zhu Tao Chen Weidong Weng Johann Jacoby Andreas K Nussler | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 6 | The influence of alanyl glutam ine on immunologic functions and morbility in postoperative to talparenteral nutrition显示文摘 | Jacobi CA Ordemann J Zuckermann H | 1999 | Zentralbl Chir1999，124，3： | 1 |
| 7 | A mechanism for the photochemical transformation of nitrate in snow 显示文摘 | Jacobi H W Hilker B | 2007 | Journal of Photochemistry and Photobiology A: Chemistry2007，185，23： | 1 |
| 8 | On the contact problem of tires including friction显示文摘 | Rothert H Idelberger H Jacobi W | 1985 | Tire Science and Technology1985，13，2： | 1 |
| 9 | Adjuvant postop- erative radiation therapy after curative resection of squamous cell carcinoma of the thoracic esophagus: a prospective ran- domized study显示文摘 | Zieren H U Muller J M Jacobi C A | 1995 | World J Surg1995，19，3： | 1 |
| 10 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai,China显示文摘 | Wang M G Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 11 | Plasmid mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | Wang M Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 12 | Hydrogen vibrations on the Ru(001) surface revisited显示文摘 | Shi H Jacobi K | 1994 | Surface Science1994，313，： | 1 |
| 13 | Generalized granuloma annulare: remission during treatment of HIV infection显示文摘 | Jacobi D Rivollier C Buisson H | 2005 | Ann Dermatol Veneral2005，132，3： | 1 |
| 14 | Magnetic resonance imaging of benign cardiac masses: a pictorial essay显示文摘 | Ward T J Kadoch M A Jacobi A H | 2013 | Clin Imaging Sei2013，3，： | 1 |
| 15 | Interaction of hydrogen with nitrogen atoms chemisorbed on a Ru(0001) Surface显示文摘 | Shi H Jacobi K Ertl G | 1995 | Journal of Chemical Physics1995，102，3： | 1 |
| 16 | Mechanism of plasmid-mediated quinolone resistance显示文摘 | TRAN J H JACOBY G A | 2002 | Proc Natl Acad Sci USA2002，99，8： | 1 |
| 17 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | Wang M Tran J H Jacoby G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 18 | Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China显示文摘 | WANG M TRAN J H JACOBY G A | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 19 | Prevalence in the United States of aac (6')-lb-cr encoding a ciprofloxacin- modifying enzyme 显示文摘 | Park C H Robicsek A Jacoby G A | 2006 | Antimicrobial Agents and Chemotherapy2006，50，11： | 1 |
| 20 | Dissociative chemisorption of nitrogen on Ru(0001)显示文摘 | Shi H Jacobi K Ertl G | 1993 | Journal of Chemical Physics1993，99，11： | 1 |
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