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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Voltage rise mitigation for solar PV integration at LV grids Studies from PVNET.dk显示文摘Solar energy from photovoltaic(PV)is among the fastest developing renewable energy systems worldwide.Driven by governmental subsidies and technological development,Europe has seen a fast expansion of solar PV in the last few years.Among the installed PV plants,most of them are situated at the distribution systems and bring various operational challenges such as power quality and power flow management.The paper discusses the modelling requirements for PV system integration studies,as well as the possible techniques for voltage rise mitigation at low voltage(LV)grids for increasing PV penetration.Potential solutions are listed and preliminary results are presented. | Guangya YANG Francesco MARRA Miguel JUAMPEREZ Søren Bækhøj KJÆR Seyedmostafa HASHEMI JacobØSTERGAARD Hans Henrik IPSEN Kenn H.B.FREDERIKSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 5 |
| 3 | New oral pharmacotherapeutic agents for venous thromboprophylaxis after total hip arthroplasty显示文摘Patients undergoing total hip arthroplasty(THA)are at high risk for developing venous thromboembolism and,therefore,require short term prophylaxis with antithrombotic agents.Recently,target specific oral anticoagulants(TSOA)including the direct thrombin inhibitor,dabigatran,and the factorⅩa inhibitors rivaroxaban,apixaban,and edoxaban have been approved for THA thrombopropylaxis in various countries.The TSOAs provide a rapid acting,oral alternative to parenteral agents including low-molecular weight heparins(LMWH)and fondaparinux;and compared to warfarin,they do not require routine laboratory monitoring and possess much fewer drug-drug interactions.Based on phaseⅢclinical studies,TSOAs have established themselvesas an effective and safe option for thromboprophylaxis after THA compared to LMWH,particularly enoxaparin,but require additional evaluation in specific populations such as the renally impaired or elderly.The ability to monitor and reverse these TSOAs in the case of bleeding complications or suspected sub-or supra-therapeutic anticoagulation is of importance,but remains investigational.This review will focus on the drug-specific characteristics,efficacy,safety,and economic impact of the TSOAs for thromboprophylaxis following THA,as well as the aspects of therapeutic monitoring and anticoagulation reversal in the event of bleeding complications or a need for urgent reversal. | Garrett B Aikens Jacob R Osmundson Michael P Rivey | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 4 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 5 | Bmi-1 collaborates with c-myc in tumorigenesis by inhibiting c-mycinduced apoptosia via INK4a/ARF显示文摘 | Jacobs JJ Scheijen B Voncken JW | 1999 | Genes Dev1999，13，20： | 1 |
| 6 | Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease显示文摘 | Das MK Khan B Jacob S | 2006 | Circulation2006，113，： | 1 |
| 7 | Enzymes as silage additives for silage quality, digestion, digestibility and performance in growing cattle显示文摘 | Jacobs J L Mc Allan A B | 1991 | Grass and Forage Science1991，46，1： | 1 |
| 8 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 9 | GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study显示文摘 | Vos PE Jacobs B Andriessen TM | 2010 | Neurology2010，75，20： | 1 |
| 10 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 11 | Effects of volume loading and pressor agents in idiopathic orthostatie tachyeardia 显示文摘 | Jacob G Shannon JR Black B | 1997 | Cir- culation1997，96，2： | 1 |
| 12 | A Curve Fitting Procedure to Derive Inter-annual Phenologies from Time Series of Noisy Satellite NDVI Data显示文摘 | BRADLEY B A JACOB R W HERMANCE J F | 2007 | Remote Sensing of Environment2007，106，2： | 1 |
| 13 | Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease 显示文摘 | Das M K Khan B Jacob S | 2006 | Circulation2006，113，2： | 1 |
| 14 | Surface energy balance closure in an arid region:role of soil heat flux显示文摘 | HEUSINKVELD B G JACOBS A F G HOLTSLAG A A M | 2004 | Agricultural and Forest Meteorology2004，122，12： | 1 |
| 15 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 16 | A genomewide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer显示文摘 | HUNTER D J KRAFT P JACOBS K B | 2007 | Nature genetics2007，39，7： | 1 |
| 17 | GFAP and SIOOB are biomarkers of traumatic brain injury: an observa- tional cohort study显示文摘 | Vos P E Jacobs B Andriessen T M | 2010 | Neurology2010，75，20： | 1 |
| 18 | A lumping and reaction scheme for catalytic cracking显示文摘 | Jacob S M Gross B Sterling E | | 0，，04： | 1 |
| 19 | Shape classification using the inner-distance显示文摘 | Ling H B Jacobs D W | | 0，，02： | 1 |
| 20 | Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease显示文摘 | Das MK Khan B Jacob S | | 0，，21： | 1 |
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