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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Hematopoietic potential of stem cells isolated from murine skeletal muscle显示文摘 | Jackson KA Mi T Goodell MA | | 0，，： | 2 |
| 3 | BCG immunotherapy of bladder cancer: 20 years on 显示文摘 | Alexandroff AB Jackson AM O' Donell MA | 1999 | Lancet1999，353，9165： | 1 |
| 4 | Paroxysmal fussing in infancy,sometimes called 'colic'显示文摘 | Wessel MA Cobb JC Jackson EB | 1954 | Paediatrics1954，14，： | 1 |
| 5 | Occult hypoglycemia caused by hemodialysis显示文摘 | Jackson MA Holland MR Nicholas J | | 0，，14： | 1 |
| 6 | Stem cell plasticity in muscle and bone marrow显示文摘 | Jackson KA Majka SM | 2001 | Ann N Y Acad Sci2001，938，： | 1 |
| 7 | Hemodialysis induced hypoglycemia in diabetic patients显示文摘 | Jackson MA Holland MR Nicholas J | | 0，，01： | 1 |
| 8 | Minimizing the risk of reporting false positives in large-scale RNAi screens显示文摘 | Echeverri C.J Beachy P.A Baum B Boutros M Buchholz F Chanda K K Downward J Ellenberg J Fraser A.G Hacohen N Hahn W.C Jackson A.L Kiger A Linsley P.S Lum L Ma Y Mathey-Prevot B Root D.E Sabatini D.M Taipale J Perrimon N and Bernards R | | 0，，： | 1 |
| 9 | Gas sensing for fire detection:measurements of CO,CO2,H2,O2 and smoke density in European standard fire tests显示文摘 | Jackson MA Robins I | 1994 | Fire Safety1994，，： | 1 |
| 10 | Failure of bonemarrow cells to transdifferentiate into neural cells in vivo 显示文摘 | Castro RF Jackson KA Goodell MA | 2002 | Science2002，297，5585： | 1 |
| 11 | Application of composted pulp and paper mill sludge to a young pine plantation 显示文摘 | Jackson M J Line MA Wilson S | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 12 | Reducing blood culture contamination in a pediatric emergency department显示文摘 | Weddle G Jackson MA Selvarangan R | | Pediatr Emerg Care0，27，3： | 1 |
| 13 | Cross-resistance re-sponse of Cry1Ac-selected Heliothis virescens(Lepidoptera:Noctuidae1)to the Bacillus thuringiesis protein vip3A显示文摘 | Jackson R E Marcus MA Gould F | 2007 | Journal of Economic Entomology2007，100，1： | 1 |
| 14 | Trigeminal neuralgia:A diagnostic Challenge显示文摘 | Jackson EM Bussard GM Hoard MA | 1999 | Am J Emerg Med1999，17，6： | 1 |
| 15 | Cell wall core galactofuran synthesis is essential for growth of mycobacteria显示文摘 | Pan F Jackson M Ma Y | 2001 | J Bacteriol2001，183，： | 1 |
| 16 | Hematopoietic potential of stem cells isolated from murine skeletal muscle显示文摘 | Jackson KA Mi T Goodell MA | 1999 | Proc Natl Acad Sci USA1999，96，25： | 1 |
| 17 | Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors显示文摘 | MacDonald JF Jackson MF Beazely MA | 2006 | Crit Rev Neurobiol2006，18，2： | 1 |
| 18 | Hematopoietic potential of stem cells isolated from murine skeletal muscle显示文摘 | Mi T Gwodell MA | 1999 | Proc Natl Acad Sci USA1999，96，14： | 1 |
| 19 | Hematopoietic potential of stem cells isolated from murine skeletal muscle显示文摘 | Jackson KA Mi T Goodell MA | 1999 | Proc Nail Acad Sci USA1999，96，14： | 1 |
| 20 | Hematopoietie potential of stem cells isolated from murine skeletal muscle 显示文摘 | Jackson KA Mi T Goodell MA | 1999 | Proc Natl Acad Sci USA1999，96，14： | 1 |
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