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57篇 您的检索式：作者名="Jackson GC"

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	题名	作者	年代	出处	被引量
1	星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。	Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊	2019	神经损伤与功能重建2019，14，6：	2
2	Competitive and noncompetitive inhibition of the DNA-dependent protein kinase显示文摘	Izzard RA Jackson SP Smith GC		0，，：	1
3	Intracelluar regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Griffith TS Chin WA Jackson GC	1998	The Journal of Immunology1998，161，6：	1
4	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells 显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，：	1
5	In vivo inhibition of tung cancer by GRN163L: a novel human telomerase inhibitor显示文摘	DIKMEN ZG GELLERT GC JACKSON S	2005	Cancer Res2005，65，17：	1
6	Serum or plasma cartilage oligomeric matrix protein concentration as a diagnostic marker in pseudoachondroplasia:differential diag- nosis of a family 显示文摘	Tufan AC Satiroglu-Tufan NL Jackson GC	2007	Eur J Hum Genet2007，15，10：	1
7	In vivo inhibition of lung cancer by GRN163L:A novel human telomerase inhibitor显示文摘	Dikmen ZG Gellert GC Jackson S	2005	Cancer Res2005，65，17：	1
8	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，6：	1
9	The DNA-dependent protein kinase显示文摘	Smith GC Jackson SP	1999	Genes & Dev1999，13，：	1
10	Low-level laser therapy as a noninvasive approach for body contouring: a randomized, con?trolled study显示文摘	Jackson RF Dedo DD Roche GC	2009	Lasers Surg Med2009，41，10：	1
11	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Chin WA Jackson GC	1998	J Immunol1998，161，：	1
12	The safety and ef- ficacy of chorionic villus sampling for early prenatal diagnosis of cyto- genetic abnormalities显示文摘	Rhoads GC Jackson LG Schlesselman SE	1989	NEJM1989，，320：	1
13	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，：	1
14	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，：	1
15	Molecular imaging and biological evaluation of HuM V833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies 显示文摘	Jayson GC Zwelt J Jackson A	2002	J Natl Cancer Inst2002，94，19：	1
16	In vivo inhibition of lung cancer by GRN163L:a novel human telomerase inhibitor显示文摘	Dikmen ZG Gellert GC Jackson S	2005	Cancer Res2005，65，17：	1
17	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，6：	1
18	Intracellular regulation of TRAIL-induced apoptosis in human melanoma cell 显示文摘	Griffith TS Chin WA Jackson GC	1998	J Immunol1998，161，6：	1
19	The DNA-dependent protein kinase显示文摘	Dmith GC Jackson SP	1999	Genes Dev1999，13，8：	1
20	Molecular imaging and biological evaluation of HuMV833 anti2VEGF antibody:implications for trial design of antiangiogenic antibodies显示文摘	Jayson GC Zweit J Jackson A	2002	J Nati Cancer Inst2002，94，：	1

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