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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Information-theoretic analysis of information hiding显示文摘 | Moulin P Joseph A O | 2003 | IEEE Transactions on Information Theory2003，49，3： | 1 |
| 3 | Expression profile of eukaryotie translation factors in human cancer tissues and cell lines 显示文摘 | Joseph P O' Kemiek C M Othumpangat S | 2004 | Mol Carcinog2004，40，3： | 1 |
| 4 | Rotation,scale,and translation invariant spread spectrum digital image watermarking显示文摘 | Joseph J K Ruanaidh (O) Thierry P | 1998 | Signal Processing1998，66，3： | 1 |
| 5 | Effect of Internal Clearance on Load Distribution and Life of Radially Loaded Ball and Roller Bearings 显示文摘 | Fred B O Erwin V Z Joseph V P | 2012 | Tribology Trans- actions2012，55，2： | 1 |
| 6 | Expression profile of eukaryotic translation factors in human cancer tissues and cell lines 显示文摘 | Joseph P O'Kernick C M Othumpangat S | 2004 | Mol Carcinog2004，40，3： | 1 |
| 7 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 8 | Landfill bioreactor:A biotechnological solution for waste management 显示文摘 | Swati M Karthikeyan O P Joseph K | 2007 | Journal of Scientific & Industrial Research2007，66，8： | 1 |
| 9 | Venous thromboembolism in trauma patients显示文摘 | Sharma O P Oswanski M F Joseph R J at al | 2007 | Am Surg2007，73，11： | 1 |
| 10 | Hearttogo: a personalized medicine technology for cardiovascular disease prevention and detection 显示文摘 | Jin Z P Joseph O Huang S M | 2009 | Life Science Systems and Applications Workshop2009，，： | 1 |
| 11 | Effects of corn on C-and L-band radar baekseatter: A correction method for soil moisture retrieval显示文摘 | Joseph A T van der Velde R O' Neill P E | 2010 | Remote Sensing of Environment2010，114，11： | 1 |
| 12 | Aggregation and organic matter fractions of three Nigerian soils as affected by soil disturbance and incorporation of plant material显示文摘 | JOSEPH O D SCHJONNING P SIBBESEN E | 1999 | Soil and Tillage Research1999，50，2： | 1 |
| 13 | Growth, behaviour, and digestive enzyme activity in larval Atlantic cod (Gadus morhua ) in relation to rotifer lipid 显示文摘 | Kelly O'Brien-MacDonald Joseph A B Christopher C P | 2006 | ICES Journal of Marine Science2006，63，2： | 1 |
| 14 | Differential epithelial and stromal protein profiles in keratoconus and normal human corneas 显示文摘 | Joseph R Srivastava O P Pfister R R | 2011 | Experimental Eye Research2011，92，4： | 1 |
| 15 | Association of Aeromonas sobria with human infection显示文摘 | Daily O P Joseph S W Coolbaugh J C | 1981 | Clin Microbiol1981，13，： | 1 |
| 16 | No impairmentin host defense against Streptococcus pneumoniae inobese CPEfat/fat mice显示文摘 | PETER M EDMLND O B JOSEPH P | 2014 | PLoS One2014，9，10： | 1 |
| 17 | Somerville3 Regulation of membrane fatty acid composition by temperature in mutants of Arabidopsis with alterations in membrane lipid composition显示文摘 | DEANE L F JOSEPH P O CHRIS R | 2004 | BMC Plant Biology2004，4，： | 1 |
| 18 | Downregu- lation of β - Actin Gene and Human Antigen R in Human Keratoconus显示文摘 | Joseph R Srivastava O P Pfister R R | 2012 | Investigative Ophthalmology & Visual Science2012，53，7： | 1 |
| 19 | Advanced oxidation processes for organic contaminant destruction based on the Fenton reaction and related chemistry显示文摘 | Joseph J P Esther O Allison M | 2006 | Environmental Science and Technology2006，36，1： | 1 |
| 20 | Decentralization in the EU Emissions Trading Scheme and lessons for global policy 显示文摘 | Joseph K Wallace E O William A P | 2007 | Review of Environmental Economics and Policy2007，1，1： | 1 |
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