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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 4 | Vanadium oxide nanostructures derived from a novel vanadium(Ⅳ) alkoxide precursor显示文摘 | Willian G Menezes Dayane M Reis | 2007 | Chem Phys Lett2007，445，46： | 1 |
| 5 | Symptomatic meck- el's diverticulum in children:a 16 year review显示文摘 | Menezes M Tareen F Saeed A | 2008 | Pediatr Surg Int2008，24，5： | 1 |
| 6 | Early exposure to caffeine affects gene expression of adenosine receptors,DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish(Danio rerio)显示文摘 | Capiotti K M Menezes F P Nazario L R | 2011 | Neurotoxicology and Teratology2011，33，6： | 1 |
| 7 | Photodynamic action of methylene blue:repair and mutation in Escherichia coli 显示文摘 | Menezes S Capella M A | 1990 | Journal of Photochemistry and Photobiology B - Biology1990，5，： | 1 |
| 8 | Chronic obstructive pulmonary disease in five Latin America cities( the PLATI - NO stud- y) : A prevalence study 显示文摘 | Meneze A M Perez - Padilla R Jardim J R | 2005 | Lancet2005，366，9500： | 1 |
| 9 | Laparoscopic appendectomy recommended for the treatment of complicated appendicitis in children显示文摘 | Menezes M Das L Alagtal M | | 0，，03： | 1 |
| 10 | Mass defoliation of the man- grove tree Avicennia germinans by the moth Hyblaea puera (Lepidoptera:Hyblaeidae) in Equatorial Brazil显示文摘 | MEHLIG U MENEZES M P M | 2005 | Ecotropica2005，1，： | 1 |
| 11 | Facility relia-bility issues in network p-median problems:Strategiccentralization and co-location effects显示文摘 | Berman O Krass D Menezes M B C | 2007 | OperationResearch2007，55，2： | 1 |
| 12 | Large-area fabrication of periodic arrays of nanoholes in metal films and their application in biosensing and plasmonic-en-hanced photovoltaics显示文摘 | MENEZES J W FERREIRA J SANTOS M J L | 2010 | Adv Funct Mater2010，20，22： | 1 |
| 13 | Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates显示文摘 | Menezes J C J M D S Kamat S P Cavaleiro J A S | 2011 | Eur J Med Chem2011，46，2： | 1 |
| 14 | The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production显示文摘 | Fabiola C. Nunes Jacqueline A. Leite Louise H. G. Oliveira Patrícia A. P. S. Sousa Márcio C. Menezes Jo?o P. S. Moraes Sandra R. Mascarenhas Valdir A. Braga | 2015 | Parasitology Research2015，，2： | 1 |
| 15 | An efficient proto- col for authenticated key agreement 显示文摘 | Law L Menezes A Qu M | 2003 | Designs Codes and Cryptography2003，28，2： | 1 |
| 16 | Analysis of the immunohistochemical expressions of p53, bel-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors 显示文摘 | Menezes H L Juc6 M J Gomes E G | 2010 | Arq Gastroenterol2010，47，2： | 1 |
| 17 | Laparoscopic appen- dectomy is recommended for the treatment of complicated appendicitis in children显示文摘 | Menezes M Das L Alagtal M | 2008 | Pediatr Surg Int2008，24，3： | 1 |
| 18 | 显示文摘 | DEMARCHI A C C O MENEZES M L MERCADANTE A | 2001 | Chromatographia2001，54，： | 1 |
| 19 | The surfac- tant addition effect in the elaboration of electrodepositated Ni - P/SiC composite coatings 显示文摘 | Malfatti C F Veit H M Menezes T L | 2007 | Surface and Coatings Technology2007，201，14： | 1 |
| 20 | Mean mesoscale global ocean currents from geodetic pre-GOCE MDTs with a synthesis of the North Pacific circulation显示文摘 | Vianna M L Menezes V V | 2010 | Journal of (Geophysical Research2010，115，02： | 1 |
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