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| 1 | 基于模糊逻辑的车辆侧偏角估计方法显示文摘提出了一种基于模糊逻辑的汽车侧偏角估计方法。它利用模糊逻辑和汽车运动学模型,将汽车转向盘转角、车轮转速、汽车加速度和横摆角速度信息相融合,进行车辆侧偏角估计。试验结果显示,该方法的鲁棒性和精确性较好,而且响应频率较高,可以满足ESP的控制需要。 | 施树明 Henk Lupker Paul Bremmer Joost Zuurbier | 2005 | 汽车工程2005，27，4： | 29 |
| 2 | Towards sustainable intensification of apple production in China—Yield gaps and nutrient use effi ciency in apple farming systems显示文摘China is in a dominant position in apple production globally with both the largest apple growing area and the largest export of fresh apple fruits.However,the annual productivity of China's apple is significantly lower than that of other dominant apple producing countries.In addition,apple production is based on excessive application of chemical fertilizers and the nutrient use efficiency(especially nitrogen)is therefore low and the nutrient emissions to the environment are high.Apple production in China is considerably contributes to farmers'incomes and is important as export product.There is an urgent need to enhance apple productivity and improve nutrient use efficiencies in intensive apple production systems in the country.These can be attained by improved understanding of production potential,yield gaps,nutrient use and best management in apple orchards.To the end,priorities in research on apple production systems and required political support are described which may lead to more sustainable and environmental-friendly intensification of apple production in China. | WANG Na Joost Wolf ZHANG Fu-suo | 2016 | Journal of Integrative Agriculture2016，15，4： | 17 |
| 3 | Evaluation of hepatic cystic lesions显示文摘Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. | Marten A Lantinga Tom JG Gevers Joost PH Drenth | 2013 | World Journal of Gastroenterology2013，19，23： | 12 |
| 4 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 5 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 6 | Dendritic Cells as a Pharmacological Target of Traditional Chinese Medicine显示文摘Dendritic cells (DCs) represent a heterogeneous population of professional antigen-presenting cells (APCs) that play a central role in the initiation and regulation of immune responses. There is considerable evidence that DCs can be used as therapeutic targets for pharmacological modulation of immune responses. Traditional Chinese medicine (TCM) has a long-standing history of using herbal medicine in the treatment of variety of human diseases. Many of the clinical effects of TCM have reportedly been attributed to the up- or down-regulation of immune responses. Accumulating evidence indicates that TCM and its components can interfere with immune responses at the earliest stage by targeting key functions of DCs. Here, we review those published studies of TCM with respect to their effects on immunobiological functions of DCs. Investigations based on both chemical entities derived from TCM as well as TCM herbal mixtures are presented. These studies suggest that various TCM herbal medicines have the capacity to inhibit or promote major functions of DCs, such as differentiation, maturation, cytokine production, survival, antigen uptake and presentation as well as trafficking. These studies have revealed novel biological effects of TCM and document the utility of this approach to discover novel biological modifier of DCfunctions derived from natural | Xin Chen Lu Yang O. M. Zack Howard Joost J. Oppenheim | 2006 | Cellular & Molecular Immunology2006，3，6： | 9 |
| 7 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 8 | 德国劳动法之体系与基本原理显示文摘对德国劳动法领域中的重要问题作简要介绍,指出个体劳动法为保护弱势方的雇员所作出的不同于一般民法的特殊规则,介绍集体劳动法中不同层面上的雇员集体利益的实现,并阐述德国劳动法的发展前景。 | Detlev Joost 王倩 | 2010 | 大连海事大学学报(社会科学版)2010，9，2： | 7 |
| 9 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 10 | MICROMECHANICS OF MACROELECTRONICS显示文摘The advent of flat-panel displays has opened the era of macroelectronics. Enthusiasm is gathering to develop macroelectronics as a platform for many technologies, ranging from paper-like displays to thin-film solar cells,technologies that aim to address the essential societal needs for easily accessible information, renewable energy, and sustainable environment. The widespread use of these large structures will depend on their ruggedness, portability and low cost, attributes that will come from new material choices and new manufacturing processes. For example, thin-film devices on thin polymer substrates lend themselves to roll-to-roll fabrication, and impart flexibility to the products. These large structures will have diverse architectures, hybrid materials, and small features; their mechanical behavior during manufacturing and use poses significant challenges to the creation of the new technologies. This paper describes ongoing work in the emerging field of research - the mechanics of macroelectronics, with emphasis on the mechanical behavior at the scale of individual features, and over a long time. | Zhigang Suo Joost Vlassa Sigurd Wagner | 2005 | China Particuology2005，3，6： | 5 |
| 11 | L-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes显示文摘 | Cecile Apert Paola Romagnoli Joost P, M. van Meerwijk | 2018 | Protein & Cell2018，9，4： | 5 |
| 12 | Long-term risk of colorectal cancer after adenoma removal: a population-based cohort study显示文摘 | Vanessa Cottet Valérie Jooste Isabelle Fournel Anne-Marie Bouvier Jean Faivre Claire Bonithon-Kopp | 2012 | Gut2012，，8： | 4 |
| 13 | The IBI1 Receptor ofβ-Aminobutyric Acid Interacts with VOZ Transcription Factors to Regulate Abscisic Acid Signaling and Callose-Associated Defense显示文摘Extemal and internal signals can prime the plant immune system for a faster and/or stronger response to pathogen attack.β-aminobutyric acid(BABA)is an endogenous stress metabolite that induces broad-spectrum disease resistance in plants.BABA perception in Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1,which activates priming of multiple immune responses,including callose-associated cell wall defenses that are under control by abscisic acid(ABA).However,the immediate signaling components after BABA perception by IBI1,as well as the regulatory role of ABA therein,remain unknown.Here,we have studied the early signaling events controlling IBI1-dependent BABA-induced resistance(BABAIR),using untargeted transcriptome and protein interaction analyses.Transcriptome analysis revealed that IBI1-dependent expression of BABA-IR against the biotrophic oomycete Hyaloperonospora arabidopsidis is associated with suppression of ABA-inducible abiotic stress genes.Protein interaction studies identified the VOZ1 and VOZ2 transcription factors(TFs)as IBI1-interacting partners,which are transcrip-tionally induced by ABA but suppress pathogen-induced expression of ABA-dependent genes.Furthermore,we show that VOZ TFs require nuclear localization for their contribution to BABA-IR by mediating augmented expression of callose-associated defense.Collectively,our study indicates that the IBI1-VOZ signaling module channels pathogen-induced ABA signaling toward cell wall defense while simultaneously suppressing abiotic stress-responsive genes. | Roland E.Schwarzenbacher Grace Wardell Joost Stassen Emily Guest Peijun Zhang Estrella Luna Jurriaan Ton | 2020 | Molecular Plant2020，13，10： | 4 |
| 14 | 提高医学行为干预的有效性显示文摘背景人类行为改变对诸如心脏病、脑卒中、癌症、糖尿病、慢性肺病和关节炎等非传染性疾病的预防和管理至关重要。行为改变包括减少吸烟、酗酒和不健康的饮食以及增加体力活动和提高对医嘱的依从度等。然而,目前的行为干预效果仍然有限。目的探讨如何利用行为改变理论和行为的生物医学决定因素知识提高行为干预的有效性。方法有选择性的综述权威性文献。结果首先,以卒中的二级预防为例,阐明在非传染性疾病中改变不健康行为的可能性和障碍。第二,以糖尿病患者行为改变为例阐明,如果应用行为改变理论精心制定干预方案,行为干预的有效性可以得到提高。第三,以骨关节炎患者的体力锻炼为例阐明,为保障行为干预的安全有效,行为的生物医学决定因素应予以考虑。结论根据行为改变理论精心设计干预方案,并充分考虑行为的生物医学决定因素可以提高行为干预的有效性。行为改变理论和生物医学知识应相互结合而不是孤立应用,才能制定更加有效的行为干预方案。 | Joost Dekker | 2016 | 中华行为医学与脑科学杂志2016，25，10： | 4 |
| 15 | 行为医学的定义与范畴:讨论、总结和更新显示文摘背景与目的目前行为医学的定义与范畴仍是25年以前的版本,因此,有必要对国际行为医学会章程中行为医学的定义和范畴进行修改、更新。本文旨在:(1)对建议修改行为医学定义与范畴的国际性讨论加以总结;(2)诚邀中国同道参与讨论。方法首先确定需要澄清或修改的问题,然后提出对行为医学定义与范畴进行更新和修改的建议。结果需要澄清或修改的问题包括:行为医学的范畴,行为医学的应用,以及行为医学、精神卫生学、健康心理学和心身医学之间的关系与区别。结论建议将行为医学的定义与范畴修改为:行为医学(behavioralmedicine)是以多学科协作为特点的、涉及与健康和疾病相关的生物医学知识和行为科学知识的发展与整合及其在预防、健康促进、诊断、治疗、康复和护理中应用的领域。行为医学的范畴从生物一行为机制(即与健康和疾病相关的生物医学、心理、社会和文化环境等进程之间的相互作用),延伸至临床诊断与干预以及公共卫生领域。诚邀中国同仁对行为医学的定义与范畴的后续讨论发表观点。 | Joost Dekker Adrienne Stauder Frank J.Penedo | 2017 | 中华行为医学与脑科学杂志2017，26，6： | 4 |
| 16 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 17 | Prevention of overuse: A view on upper gastrointestinal endoscopy显示文摘Many upper gastrointestinal(GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines,uncertainty about etiology of symptoms, and therapy failure. Unfiltered openaccess referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dyspepsia. First,we describe the impact of active guideline implementation. We found improved guideline adherence, but resistance was encountered in the process. Secondly, we show several forms of clinical assessment. While algorithm use reduced upper GI endoscopy volume, effects of referral assessment of individual patients were minor. A third strategy proposed Helicobacter pylori test and treat for all dyspeptic patients. Many upper GI endoscopies can be avoided using this strategy, but outcomes may be prevalence dependent. Lastly, empirical treatment with Proton pump inhibitors achieved symptom relief for dyspepsia and avoided upper GI endoscopies in about two thirds of patients. Changing referral behavior is complex as contributing factors are manifold. A collaboration of multiple strategies is most likely to succeed. | Judith J de Jong Marten A Lantinga Joost PH Drenth | 2019 | World Journal of Gastroenterology2019，25，2： | 3 |
| 18 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 19 | 关于金属板材渐进成型的高级特征检测算法(英文)显示文摘提出一种关于单点渐进成形(SPIF)部件的特征检测的新型算法。基于自建的关于SPIF的CAPP专家系统,通过对几何形状、曲率、位置、方位、加工参数的综合分析,可以检测33种不同的特征可以检测。为了加快检测过程,首先使用多级边缘分割算法创建一个边缘特征的框架。随后在这个框架中,区域生长算法被用来检测剩余的特征。这个检测方法已经成功地被不同的实验所验证。采用一个双曲面半球的实验案例描述通过对检测的特征进行补偿,从而生成最优的刀具路径。结果显示,优化的刀具路径对于成形部件的精度有很大的提高。 | Amar Kumar BEHERA Bert LAUWERS Joost R. DUFLOU | 2012 | 中国有色金属学会会刊:英文版2012，22，S2： | 3 |
| 20 | Mapping theArabidopsis Metabolic Landscape by Untargeted Metabolomics at Different Environmental Conditions显示文摘新陈代谢的染色体宽的协会研究(mGWAS ) ,因此,代谢物层次被认为是特点,帮助能解开新陈代谢的网络的基因基础。309 Arabidopsis 就职的一个总数在二个独立环境条件(控制和应力) 下面被种并且使遭到到介绍的 untargeted LC-MS-based metabolomic;获得的吸水的代谢物的层次在 GWAS 被使用。我们为超过 3000 半极的代谢物的 two-condition-based GWAS 导致了 123 高度解决的代谢物的察觉量的特点 loci ?(p 1.0E-08 ) 。有趣地,不同地,从在 Arabidopsis 主要代谢物,趋于被很多小效果的 loci 控制,的自然变化,我们在发现几个学生大效果的 loci 控制第二等的代谢物的变化的小效果的 loci 的一个广阔数字。two-condition-based GWAS 被集成用一个时间功课压力实验与导出网络的代谢物抄本关联跟随。通过这条综合途径,我们选择了在结构的基因和代谢物之间的 70 个关键候选人协会,并且试验性地验证了八个新奇协会,他们中的二个在二环境的出现微分基因规定学习了。我们表明联合有 time-course-derived 网络的基于 metabolomics 的 GWAS 两个都为识别代谢物基因协会在不同不能生活的环境下面执行了的大规模 untargeted 的力量,提供进 Arabidopsis 的新陈代谢的风景的新奇全球卓见。 | Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenboim Rik Kooke Michael Meret Joost B. Keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv Brotman | 2018 | Molecular Plant2018，11，1： | 3 |
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