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| 1 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 2 | Modular,mobile-bearing hinge total knee arthroplasty 显示文摘 | Jones RE Barrack RL Skedros J | 2001 | Clin Orthop2001，392，： | 2 |
| 3 | Fibrinopeptide A in diabetes mellitus: relation to levels of blood glucose, fibrinogen disappearance and hemodynamic changes显示文摘 | Jones RL | 1985 | Diabetes1985，34，： | 1 |
| 4 | The chemokines,CX3CL1,CCL14,and CCL4,promote human trophoblast migration at the feto-maternal interface显示文摘 | Hannan NJ Jones RL White CA | 2006 | Biol Reprod2006，74，5： | 1 |
| 5 | Irritable bowel syndrome in twins:heredity and social learning both contribute to etiology显示文摘 | LEVEY RL JONES KR WHITEHEAD WE | 2001 | Gastroenterology2001，121，4： | 1 |
| 6 | Relationship between oestrogen receptor status and proliferation in predicting response and long term outcome to neoadjuvant chemo?therapy cancer显示文摘 | Jones RL Salte A'Hern R | 2010 | Cancer Res Treat2010，119，2： | 1 |
| 7 | Neoadjuvant treatment for early-stage breast cancer:opportunities to assess tumour response显示文摘 | Jones RL Smith IE | | 0，，： | 1 |
| 8 | Obesity is a risk factor for dyspnea but not for airflow obstruction显示文摘 | Sin DD Jones RL Man SF | | 0，，： | 1 |
| 9 | Relatonship between maternal growth,infant birthweight and nutrient partitioning in teenage pregnancies显示文摘 | Jones RL Cederberg HM Wheeler SJ | 2010 | BJOG2010，117，2： | 1 |
| 10 | Irritable bowel syn- drome in twins:heredity and social learning both contribute to etiology 显示文摘 | Levy RL Jones KR Whitehead WE | 2001 | Gastroenterology2001，121，4： | 1 |
| 11 | Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregancy and in women using progestin only contraception 显示文摘 | Jones RL Salamonsen LA Critchley HOD | 2000 | Molecular Human Reproduction2000，6，： | 1 |
| 12 | Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracy- dine-treated patients 显示文摘 | Tan DS Marehio C Jones RL | 2008 | Breast Cancer Res Treat2008，111，5： | 1 |
| 13 | TGF-β superfamily expression and actions in the endometrium and placenta 显示文摘 | Jones RL Stoikos C Findlay JK | 2006 | Reproduction2006，132，2： | 1 |
| 14 | Triple negative breast cancer:molecular profiling and prognostic impact in adjuvant anthracycline treated patients显示文摘 | Tan DS MarchióC Jones RL | 2008 | Breast Cancer Res Treat2008，111，1： | 1 |
| 15 | Cost analysis of intensive glycemic control in critically ill adult patients显示文摘 | Krinsley JS Jones RL | | 0，，03： | 1 |
| 16 | Prostanoid and leukotrenie receptors: a progress report from the IUPHAR working parties on classification and nomenclature显示文摘 | Coleman RA Eglen RM Jones RL | 1995 | Adv Prostagladin Thromboxane Leukot Res1995，23，： | 1 |
| 17 | Irritable bowel syndrome in twins:heredity and social, learning both contribute to etiology 显示文摘 | Levy RL Jones KR Whitehead WE | 2001 | Gastroenterol2001，121，4： | 1 |
| 18 | Nuclear NF-κB/p65 expression and response to neoadjuvant chemotherapy in breast cancer显示文摘 | Jones RL Rojo F A'Hern R | | 0，，02： | 1 |
| 19 | Nuclear NF-KB/p65 expression and response to neoadjuvant chemotherapy in breast cancer显示文摘 | Jones RL Rojo F A'Hem R | 2011 | J Clin Pathol2011，64，2： | 1 |
| 20 | Airway smooth muscle hyper- trophy and hyperplasia in asthma显示文摘 | James AL Elliot JG Jones RL | 2012 | Am J Respir Crit Care Med2012，185，10： | 1 |
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