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| 1 | Breast cancer stem cells areregulated by mesenchymal stem cells through cytokine net-works显示文摘 | JLiu S Ginestier C Ou SJ | 2011 | Cancer Res2011，71，2： | 1 |
| 2 | Capeeitabine is effective and very well tolerated in Chinese natients with pretreated advanced or relapsed breast carcinoma显示文摘 | Chu D W Li JLiu | 2003 | Proe Am Soe Clin Oncol2003，22，： | 1 |
| 3 | Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions. | William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu | 2019 | Biosafety and Health2019，1，1： | 1 |
| 4 | Net primary productivity mapped for Canada at 1‐km resolution显示文摘 | JLiu J. M.Chen J.Cihlar W.Chen | 2002 | Global Ecology and Biogeography2002，，2： | 1 |
| 5 | Inheritance of plant regeneration from maize ( Zea mays L) shoot meristem cultures derived from germinated seeds and the identification of the associatied RAPD AND SSR markers显示文摘 | WLI GSUN JLIU | 2004 | Theoretical and Applied Genetics2004，108，4： | 1 |
| 6 | Predicting Compost Stability显示文摘 | Hue NV JLiu | 1995 | Compost Science & Utilization1995，3，2： | 1 |
| 7 | Compression behaviour of Pd39Ni10Cu30P21 bulk metallic glass up to 23.5Gpa显示文摘The compression behaviour of Pd39Ni10Cu30P21 bulk metallic glass is ivestigated at room temperature up to 23.5GPa using in situ high pressure energy dispersive x-ray diffraction with a synchrotron radiation source.Pressure induced strucural relaxation of the bulk metallic glass is exhibited within the pressure range.It is found that below about 5GPa,the existence of excess free volume contributes to rapid structural relaxation,which gives rise to rapid volumetic change.Under higher pressure,further relaxation results in structural stiffness. | LMWang ZJZhan JLiu LLSun GLi WKWang | 2001 | Beijing Synchrotron Radiation Facility2001，，2： | 0 |
| 8 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 9 | Three Cases Infected with Avian Influenza A(H5N6)Virus-Chongqing Municipality,China,January-September,2021显示文摘Summary What is already known about this topic?The World Health Organization(WHO)has reported a total of 48 cases by October 15,2021.The continuous genomic reassortments of H5N6 and other subtype avian influenza viruses(AIVs)pose a long-term threat to public health and the poultry industry.What is added by this report?Three new cases of H5N6 that occurred from January to September 2021 in Chongqing Municipality,China were reported in this study.Epidemiological information of the three cases showed raising poultry and visiting live poultry market contributed to these infections,and there was no evidence of human-to-human transmission of H5N6 currently but a potential spatial cluster.An increase of H5N6 cases was recorded in the area.What are the implications for public health practice?In case of unexplained pneumonia or severe respiratory infection,the patients’epidemiological history of contact with poultry or live poultry markets(LPMs)may be an important interrogation to help diagnose.Extensive and long-term surveillance of avian influenza viruses in LPMs is essential. | Kun Su Zhen Yu Yu Lan Ju Wang Shuang Chen Li Qi Yaokai Chen Yun Tang Yu Xiong Zhangping Tan Mingyue Wang Sheng Ye Dayan Wang Hua Ling William JLiu Xiaoni Zhong Qin Li Wenge Tang | 2022 | China CDC weekly2022，4，1： | 0 |
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