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84篇 您的检索式：作者名="JC Jansen"

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	题名	作者	年代	出处	被引量
1	miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。	van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊	2018	神经损伤与功能重建2018，13，12：	3
2	Predictors of the rate of residual renal function in incident dialysis patients显示文摘	Jansen MA Hart AA Korevarr JC	2002	Kidney Int2002，62，3：	1
3	Estimation of growthrat patients with head and neekparagangliom as influences the treatment proposal显示文摘	Jansen JC Vanden Berg R Kuiper A	2000	Cancer2000，88，12：	1
4	Validation of the KDQOL-SF: a dialysis-targeted health measure 显示文摘	Korevaar JC Merkus MP Jansen MA	2002	Qual Life Res2002，11，5：	1
5	Budd-Chiari syndrome:a review by an expert panel显示文摘	Jansen HL Garcia-Pagan JC Elias E	2003	J Hepatol2003，38，3：	1
6	Does age really matter? Recall of information presented to newly referred patients with cancer显示文摘	Jansen J Butow PN van Weert JC	2008	J Clin Oncol2008，26，33：	1
7	When to initiate dialysis:effect of proposed US guidelines on survival显示文摘	Korevaar JC Jansen MA Dekker FW	2001	Lancet2001，358，9287：	1
8	Effects of communication skills training and a Question Prompt Sheet to improve communication with older cancer patients: a randomized controlled trial显示文摘	Van Weert JC Jansen J Spreeuwenberg PM	2011	Crit Rev Oncol Hematol2011，80，1：	1
9	Growth and growth pressure of mandibular condylar and some primary cartilages of the rat in vitro 显示文摘	Copray JC Jansen HW Duterloo HS	1986	Am J Orthod Dentofacial Orthop1986，90，1：	1
10	Predictors of the rate of decline of residual renal function in incident dialysis patients显示文摘	Jansen MA Hart AA Korevaar JC		0，，：	1
11	Predictors of the rate of decline of residual renal function in incident dialysis patients.显示文摘	Jansen MA Hart AA Korevaar JC		0，，：	1
12	Growth and growth pressure of mandibular condylar and some primary cartilages of the rat in vitro显示文摘	Copray JC Jansen HW Duterloo HS	1986	Am J Orthod Dentofacial Orthop1986，90，1：	1
13	Quality of life in predialysis end-stage renal disease patients at the initiation of dialysis therapy. The NECOSAD Study Group显示文摘	JC Korevaar MA Jansen MP Merkus FW Dekker EW Boeschoten RT Krediet	2000	Peritoneal Dialysis International2000，，1：	1
14	An in-vitro system for studying the effect of variable compressive forces on the mandibular condylar cartilage of the rat显示文摘	Copray JC Jansen HW Duterloo HS	1985	Arch Oral Biol1985，30，4：	1
15	Effect of compressive forces on phosphatase activity in mandibular condylar cartilage of the rat in vitro 显示文摘	Copray JC Jansen HW Duterloo HS	1985	J Anat1985，140，3：	1
16	Estimation of Growth Rate Patients with Head and Neck Paragangliomas Influences the Treatment Proposal显示文摘	Jansen JC Vanden Berg R Kuiper A	2000	Cancer2000，88，12：	1
17	Validation of the KDQOL-SF TM: A dialysis- targeted health measure显示文摘	Korevaar JC Merkus MP Jansen MAM	2002	Qual Life Res2002，11，5：	1
18	Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene显示文摘	Taschner PE Jansen JC Baysal BE	2001	Genes Chromosomes Cancer2001，31，3：	1
19	Estimation of growth rate in patients with head and neck paragangliomas influences the treatment proposal显示文摘	Jansen JC van den Berg R Kuiper A		0，，12：	1
20	Histologic evaluation of the effect of formocresol and glutaraldehyde on the periapical tissues endodontic treatment 显示文摘	Wemes JC Jansen HWB Purdell-Lewis D	1982	Oral Surg1982，54，3：	1

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