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| 1 | Environmental Stresses Modulate Abundance and Timing of Alternatively Spliced Circadian Transcripts in Arabidopsis显示文摘环境压力深刻地包括保留 intron (红外) 改变了胡说八道 mRNAs 的累积在 Arabidopsis 的抄本。导致压力的红外 mRNAs 的时间的模式用震荡和不振荡的抄本被把。宽广范围的热周期在长红外 CCA1 isoforms 触发了锋利的增加并且改变了他们分阶段执行到白天的不同时间。象干旱或 Pseudomonas syringae 感染那样的不能生活、关於生命的压力导致了类似的增加。热应力在 CCA1 I4Rb 抄本的累积导致了时间延期,而功能的 mRNA 显示出稳定的摆动。我们的数据帮助中央振荡器的导致压力的不稳定性能部分地在丰富和 CCA1 红外抄本的 out-of-phase 摆动通过变化被补偿的一个假设。一起拿,我们的结果支持 mRNA 丰富能通过改变比率在之间被调制的一个概念功能并且胡说八道 / 红外抄本。明确地绑在保留的 CCA1 intron 在的 SR45 蛋白质 ? vitro,建议这个拼接的因素能涉及 intron 保留的规定。调停胡说八道的 mRNA 腐烂(NMD ) 的 Transcriptomes 损害了,强调热的植物分享了与压力可诱导、防卫可诱导的抄本联系的一套保留的 introns。在 NMD 异种的某些压力反应网络的组成的激活能被连接到不平衡在之间功能并且胡说八道 mRNAs。 | Sergei A. Filichkin Jason S. Cumbie Palitha Dharmawardhana Pankaj Jaiswal Jeff H. Chang Saiprasad G. Palusa A.S.N. Reddy Molly Megraw Todd C. Mockler | 2015 | Molecular Plant2015，8，2： | 11 |
| 2 | Role of Moringa oleifera in regulation of diabetes-induced oxidative stress显示文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage. | Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha Shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair Geeta Watal | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 11 |
| 3 | Triple plating of tibia in a complex bicondylar tibial plateau fracture显示文摘高精力的胫骨的高原骨折为整形外科的外科医生提出重要挑战和困难。胫骨的高原的骨折包含主要重量适用连接并且可以改变膝 kinematics。近似胫骨的关节的表面,手足轴(手足排列) 的恢复和允许早联合的运动的稳定的固定的解剖重建是处理的目标。在胫骨的高原折断的复杂 bicondylar 的情况下,孤立侧面的 plating 经常与内翻足 malalignment 被联系,更好的结果通过双切口与双边的 plating 被获得了。然而,有时,胫骨的高原折断的 bicondylar 的一种复杂类型在中间的高原在哪个让 biplaner 象 sagittal 飞机一样在以后的花冠飞机断裂被遇到。在如此的破裂,与在两架飞机支持修理中间的高原是必要的。近似胫骨的一个如此的破裂模式通过双 posteromedial 由三倍的 plating 设法,在前面偏一边的切口在这类损害,外科的途径和管理的机制上与强调在这份情况报告被讨论。 | Atin Jaiswal Naiman Deepak Kachchhap Yashwant S Tanwar Birendra Kumar Sachin K Yadav | 2014 | Chinese Journal of Traumatology2014，17，3： | 10 |
| 4 | Molecular mechanism of noradrenaline during the stress-induced major depressive disorder显示文摘Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity rate.Stress-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of depression.Lack of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder(MDD) and several antidepressants functions by increasing the monoamine level at the synapses in the brain.However,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of antidepressant.Contrary to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of antidepressant.In addition,enhanced noradrenaline(NA) release is central response to stress and thought to be a risk factor for the development of MDD.Moreover,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus(LC).However,it is unclear how they alter the firing activity of LC neurons.These inconsistent reports about antidepressant effect of NA-reuptake inhibitors(NRIs) and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of MDD.In this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in MDD.We will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis(HPA-axis) and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD. | Kenjiro Seki Satomi Yoshida Manoj Kumar Jaiswal | 2018 | Neural Regeneration Research2018，13，7： | 10 |
| 5 | MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα显示文摘In human adipose tissue and obesity,miR-99a expression is negatively correlated with inflammation.Therefore,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes.Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype.Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity.Likewise,knockdown of miR-99a abolished M2 phenotype activation.By means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of miR-99a.Knockdown of TNFαrecapitulated the effect of miR-99a overexpression in M1 BMDMs.In a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+ATMs.Systemic overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 immunostaining.Flow cytometry analysis also showed an increased M2 and a reduced M1 macrophage population.Mimics of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the liver.Furthermore,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and liver.The present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity. | Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya Manoj Kumar Barthwal | 2019 | Cellular & Molecular Immunology2019，16，5： | 7 |
| 6 | Is prophylactic placement of drains necessary after subtotal gastrectomy?显示文摘AIM: To determine the evidence-based values of prophylactic drainage in gastric cancer surgery. METHODS: One hundred and eight patients, who underwent subtotal gastrectomy with D1 or D2 lymph node dissection for gastric cancer between January 2001 and December 2005, were divided into drain group or no-drain group. Surgical outcome and post-operative complications within four weeks were compared between the two groups. RESULTS: No significant differences were observed between the drain group and no-drain group in terms of operating time (171 ± 42 min vs 156 ± 39 min), number of post-operative days until passage of flatus (3.7 ± 0.5 d vs 3.5 ± 1.0 d), number of post-operative days until initiation of soft diet (4.9 ± 0.7 d vs 4.8 ± 0.8 d), length of post-operative hospital stay (9.3 ± 2.2 d vs 8.4 ± 2.4 d), mortality rate (5.4% vs 3.8%), and overall post- operative complication rate (21.4% vs 19.2%). CONCLUSION: Prophylactic drainage placement is not necessary after subtotal gastrectomy for gastric cancer since it does not offer additional benefits for the patients. | Manoj Kumarl Seung Bong Yangl Vijay Kumar Jaiswall Jay N Shahl Manish Shreshthal Rajesh Gongal | 2007 | World Journal of Gastroenterology2007，13，27： | 7 |
| 7 | Review: Bioengineering approach for the repair and regeneration of peripheral nerve显示文摘Complex craniofacial surgeries of damaged tissues have several limitations,which present complications and challenges when trying to replicate facial function and structure.Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks.As technology continues to advance,new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure.This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds,bioactive factors,and external stimuli alone or in combination to support peripheral nerve regeneration.Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G.Kumbar | 2019 | Bioactive Materials2019，4，1： | 6 |
| 8 | Tissue-based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro-dissection显示文摘Achyranthes bidentata and Achyranthes aspera are saponin and steroid rich medicinal plants, used extensively for therapeutic treatments in Traditional Chinese Medicine(TCM) and Ayurveda. A. bidentata is reported to be one of the rare and extensively exploited medicinal plant species that face the issue of being endangered.Finding qualitative substitute with identical phyto-constituents contributing to similar composition and pharmacological benefits will help in reducing the burden of exploitation of the natural habitats of such plants.In the present study, a comparative metabolite analysis of the whole drug and specific tissues isolated by laser micro-dissection(LMD) was carried out for both the selected species, by use of ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS). The results of the study indicate that the cortex and the medullary ray tissues are rich in their content of steroidal and saponin constituents such as(25 S)-inokosterone-20,22-acetonide, ginsenoside Ro, bidentatoside II and achyranthoside B.Metabolite profiling of the whole tissues of both the species indicates presence of identical constituents. Thus,it is inferred that A. bidentata and A. aspera can be used as qualitative substitutes for each other. | Yogini Jaiswal Zhitao Liang Alan Ho Hubiao Chen Leonard Williams Zhongzhen Zhao | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 5 |
| 9 | Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2018 | World Journal of Diabetes2018，9，12： | 5 |
| 10 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 11 | A generalized three-dimensional failure criterion for rock masses显示文摘The smooth convex generalized failure function, which represents 1/6 part of envelope in the deviatoric plane, is proposed. The proposed function relies on four shape parameters (Ls, a, b and c), in which two parameters (a and b) are dependent on the others. The parameter L s is called extension ratio. The proposed failure function could be incorporated with any two-dimensional (2D) failure criteria to make it a three-dimensional (3D) version. In this paper, a mathematical formulation for incorporation of Hoek-Brown failure criterion with the proposed function is presented. The Hoek-Brown failure criterion is the most suited 2D failure criterion for geomaterials. Two types of analyses for best-fitting solution of published true tri-axial test data were made by considering (1) constant extension ratio and (2) variable extension ratio. The shape and strength parameters for different types of rocks have been determined by best-fitting the published true tri-axial test data for both the analyses. It is observed from the best-fitting solution by considering uniform extension ratio (Ls) that shape constants have a correlation with Hoek-Brown strength parameters. Thus, only two parameters (σc and m) are needed for representing the 3D failure criterion for intact rock. The statistical expression between shape and Hoek-Brown strength parameters is given. In the second analysis, when considering varying extension ratio, another parameter fis introduced. The modified extension ratio is related to f and extension ratio. The results at minimum mean misfit for all the nine rocks indicate that the range of f varies from 0.7 to 1.0. It is found that mean misfit by considering varying extension ratio is lower than that in the first analysis. But it requires three parameters. A statistical expression between f and Hoek-Brown strength parameters has been established. Though coefficient of correlation is not reasonable, we may eliminate it as an extra parameter. At the end of the paper, a methodology has also been given for its application to isotropic jointed rock mass, so that it can be implemented in a numerical code for stability analysis of jointed rock mass structures. | Ashok Jaiswal B.K.Shrivastva | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 4 |
| 12 | Optimality Conditions and Duality for Nondifferentiable Multiobjective Semi-Infinite Programming Problems with Generalized(C,α,ρ,d)-Convexity显示文摘This paper obtains sufficient optimality conditions for a nonlinear nondifferentiable multiobjective semi-infinite programming problem involving generalized(C,α,ρ,d)-convex functions.The authors formulate Mond-Weir-type dual model for the nonlinear nondifferentiable multiobjective semiinfinite programming problem and establish weak,strong and strict converse duality theorems relating the primal and the dual problems. | MISHRA Shashi Kant JAISWAL Monika HOAI AN Le Thi | 2015 | Journal of Systems Science & Complexity2015，28，1： | 4 |
| 13 | 皮质类固醇对导管消融术后心房颤动影响的荟萃分析(英文)显示文摘目的:探讨皮质类固醇对导管消融术后心房颤动(AF)的影响。创新点:首个探讨皮质类固醇对导管消融术后AF影响的荟萃分析。方法:我们在Pub Med、Embase和Cochrane对照试验中心注册库中搜索了描述皮质类固醇对预防导管消融后AF复发影响的文章,并提取了研究和患者的相关数据。使用随机效应模型计算风险比(RR)和95%置信区间(CI),P<0.05被认为具有统计学差异。结论:导管消融术围术期皮质类固醇的使用与AF早期复发减少相关,但与晚期复发无关。 | Sanjay JAISWAL Xian-bao LIU Qu-cheng WEI Ying-hao SUN Li-han WANG Liu-guang SONG Dan-dan YANG Jian-an WANG | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，1： | 4 |
| 14 | Instability Analysis of Mosquito Fascicle under Compressive Load with Vibrations and Microneedle Design显示文摘 | Sanket Jaiswal Sreekumar Muthuswamy | 2015 | Journal of Bionic Engineering2015，12，3： | 3 |
| 15 | Future directions of clinical laboratory evaluation ol pregnancy显示文摘在最近的年里,我们免疫系统怎么与发展中的胎儿和胎盘交往的理解极大地膨胀了。有许多实验室,在有周期性的怀孕损失(RPL ) 或子间前的女人为怀孕结果的诊断提供测试。这些测试基于对胎儿的有免疫力的反应等价于的前提对的适应有免疫力的反应一 transplant。新理解导致激活的天生的反应为怀孕是重要的,这能导致以后阻止反常怀孕的更有效的测试和处理的概念。我们这里为未来测试描述仅仅三个如此的区域:一个区域包含精子和精液和为成功的授精必要的因素;另一个区域将在子宫为为培植必要的生长因素的生产决定条件;最后,最后区域将是由激活的生来的杀手(NK ) 决定为胎盘和成长胎儿的 vascularization 必要的条件房间(漂亮房间的联合有 HLA-C haplotypes 的像免疫球蛋白的受体(KIR ) 家庭基因) 导致 secreting angiogenic 生长因素的能力。这些区域是新奇的,但是理解他们在怀孕的角色能导致进怎么与复杂化因素维持并且对待怀孕的卓见。 | Kenneth D Beaman Mukesh K Jaiswal Svetlana Dambaeva Alice Gilman-Sachs | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 16 | JASN:研究鉴定出可能让HIV感染肾细胞的受体显示文摘HIV-1相关肾病是一种能够在未合适地利用抗逆转录病毒疗法加以治疗的非洲裔HIV阳性患者体内产生的肾病。尽管经过多年的广泛研究。人们仍不清楚来自HIV阳性患者的并不表达主要的HIV-1CD4受体的肾上皮细胞是如何被HIV-1感染的。 | Jinliang Li* Jharna R. Das* Pingtao Tang* Zhe Han Jyoti K. Jaiswal* Patricio E. Ray* | 2017 | 现代生物医学进展2017，17，8： | 2 |
| 17 | Bombings specific triage(Bost Tool) tool and its application by healthcare professionals显示文摘BACKGROUND: Bombing is a unique incident which produces unique patterns, multiple and occult injuries. Death often is a result of combined blast, ballistic and thermal effect injuries. Various natures of injury, self referrals and arrival by private transportation may lead to 'wrong triage' in the emergency department. In India there has been an increase in incidence of bombing in the last 15 years. There is no documented triage tool from the National Disaster Management Authority of India for Bombings. We have tried to develop an ideal bombing specific triage tool which will guide the right patients to the right place at the right time and save more lives.METHODS: There are three methods of studying the triage tool: 1) real disaster; 2) mock drill; 3) table top exercise. In this study, a table top exercise method was selected. There are two groups, each consisting of an emergency physician, a nurse and a paramedic.RESULTS: By using the proportion test, we found that correct triaging was significantly different(P=0.005) in proportion between the two groups: group B(80%) with triage tool performed better in triaging the bomb blast victims than group A(50%) without the bombing specific triage tool performed.CONCLUSION: Development of bombing specific triage tool can reduce under triaging. | Jaiswal Sanjay Verma Ankur Kole Tamorish | 2015 | World Journal of Emergency Medicine2015，6，4： | 2 |
| 18 | Bilateral traumatic proximal humerus fractures managed by open reduction and internal fixation with locked plates显示文摘近似肱骨的破裂在年轻病人是不平常的。尽管近似肱骨本身的双边的骨折是稀罕的,有癫痫和电刑的协会是经常的。仅仅创伤的双边的近似肱骨骨折的一个案例在文学被报导了。我们在 40 岁男性病人报导双边的创伤的代替的近似肱骨破裂的一个稀罕案例,它与近似肱骨借助于开的减小和内部固定被对待在双方上锁了头并且获得了好功能的结果。 | Atin Jaiswal Naiman Deepak Kachchhapt Rupak Chaterjee Yashwant Singh Tanwar Masood Habib Satya Prakash Singh | 2013 | Chinese Journal of Traumatology2013，16，6： | 2 |
| 19 | Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease显示文摘Amyotrophic lateral sclerosis(ALS) and motor neuron diseases(MNDs) are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons(UMNs/LMNs), brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons(MNs), muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro 'disease in dish' and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs. | Manoj Kumar Jaiswal | 2017 | Neural Regeneration Research2017，12，5： | 2 |
| 20 | First rib fractures: not always a hallmark of severe trauma a report of three cases显示文摘 | Atin Jaiswal Yashwant S Tanwar Masood Habib Vijay Jain | 2013 | Chinese Journal of Traumatology2013，16，4： | 2 |
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