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| 1 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 2 | Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes:comparison,efficacy and safety 显示文摘 | Deacon CF Holst J1 | 2013 | Exp OpinPharm2013，14，15： | 1 |
| 3 | Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice 显示文摘 | Chen J1 Zhang C Jiang H Li Y | 2005 | Cereb Blood Flow Metab2005，25，2： | 1 |
| 4 | Panax notoginseng saponins(PNS)inhibits breast Cancer metastasis显示文摘 | Wang P1 Cui J1 Du X1 | 2014 | J Ethnopharmacol2014，，14： | 1 |
| 5 | Biomechanical evaluation of metacarpal fracture f'Lxation: application of a 90° internal fixation model显示文摘 | Watt A J Ching RP Huang J1 | 2015 | Hand ( N Y)2015，10，1： | 1 |
| 6 | Comparing hea!thcare costs of Medicaid patients with postherpetic neuralgia (PHN) treated with li- docaine patch 5% versus gabapentin or pregabalin显示文摘 | Kirson NY Nanova J1 Birnbaum HG | 2010 | J Med Econ2010，13，3： | 1 |
| 7 | Isokinetic evealuation of rotational strength in normal shouler and shoulders with impingment syndrome 显示文摘 | Leroux J1 Codine P Thomas E | 1994 | Clin Orthop Relat Res1994，30，4： | 1 |
| 8 | Distribution of substituents in carboxymethyl ethers of cyclomaltoheptaose 显示文摘 | Ben J R Rao C T Pitjha J1 | 1994 | Carbohydrate research1994，258，： | 1 |
| 9 | PBSC autotransplanl forinflammatory bowel disease:a case of ulcerative colitis 显示文摘 | Marti JL Mayordomo J1 lsla MD el al | 2001 | Bone Marrow Transplant2001，28，： | 1 |
| 10 | Toxoplasma tondii infection in the Unit- ed States,1999 -2000显示文摘 | Jone J1 Deanna KM Wilson W | 2003 | Emerg Infest Dis J2003，9，11： | 1 |
| 11 | Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Im- pairment显示文摘 | Armstrong M J1 Naglie G Duff-Canning S | 2012 | Dement Geriatr Cogn Dis Extra2012，2，1： | 1 |
| 12 | Clinical Evaluation of the Di- versiLab Microbial Typing System using Rep - PCR for Strain Charac- terization of Staphylococcus aureus 显示文摘 | Schutt CK Pounder J1 Page SR | 2005 | J Clin Microbiol2005，43，3： | 1 |
| 13 | HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis显示文摘 | Henter J1 Horne A Aricó M | | 0，，： | 1 |
| 14 | Parathyroid hormone,but not vitamins D,is associated with the metabolic syndrome in morbidly obese women and men:a crosssectional study显示文摘 | Hjelmesaeth J1 Hofs?D Aasheim ET | 2009 | Cardiovasc Diabetol2009，8，1： | 1 |
| 15 | Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrindependent transmigration of monocytes in renal fibrosis显示文摘 | Dennis J1 Meehan DT Delimont D | 2010 | Pathol2010，177，5： | 1 |
| 16 | Epidemiology and genetics of alopecia areata显示文摘 | McDonagh A J1 Tazi-Ahnini R | 2002 | Clin Exp Dermato12002，27，5： | 1 |
| 17 | Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis显示文摘 | Chai J1 Luo D Wu X | 2011 | J Gastrointest Surg2011，15，6： | 1 |
| 18 | Dose - response study of recombinant human soluble thrombomodulin ART- 123 )in the prevention of venous thromboembolism after total hip replacement 显示文摘 | Comp P Douketis J1 | 2005 | Thromb Hae- most2005，3，5： | 1 |
| 19 | Implication of recent clini- cal trials for the national cholesterol education program adult treatment panel Ⅲ guidelines 显示文摘 | Grundy SM Cleeman J1 Bairey NM | 2004 | Circulation2004，110，： | 1 |
| 20 | A highly efficient oxidation ofcyelohexane over Au/ZSM 5 molecular sieve catalyst with oxygen as oxidant显示文摘 | ZHAO R J1 D LU G M | 2004 | Chem Commun2004，，7： | 1 |
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