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| 1 | Sonic hedgehog signaling in kidney fibrosis: a master communicator显示文摘The hedgehog signaling cascade is an evolutionarily conserved pathway that regulates multiple aspects of embryonic development and plays a decisive role in tissue homeostasis. As the best studied member of three hedgehog ligands, sonic hedgehog(Shh) is known to be associated with kidney development and tissue repair after various insults. Recent studies uncover an intrinsic link between dysregulated Shh signaling and renal fibrogenesis. In various types of chronic kidney disease(CKD), Shh is upregulated specifically in renal tubular epithelium but targets interstitial fibroblasts, thereby mediating a dynamic epithelialmesenchymal communication(EMC). Tubule-derived Shh acts as a growth factor for interstitial fibroblasts and controls a hierarchy of fibrosis-related genes, which lead to the excessive deposition of extracellular matrix in renal interstitium. In this review, we recapitulate the principle of Shh signaling, its activation and regulation in a variety of kidney diseases. We also discuss the potential mechanisms by which Shh promotes renal fibrosis and assess the efficacy of blocking this signaling in preclinical settings. Continuing these lines of investigations will provide novel opportunities for designing effective therapies to improve CKD prognosis in patients. | Dong Zhou Roderick J.Tan Youhua Liu | 2016 | Science China(Life Sciences)2016，59，9： | 18 |
| 2 | Deformation behaviors of Cu bicrystals with an inclined twin boundary at multiple scales显示文摘Cu bicrystals of different sizes with a sole twin boundary(TB) inclined at 45?with respect to the loading direction were deformed under unidirectional and cyclic loading, respectively. It is found that the slip bands(SBs) parallel to the TB can be activated near the TB at all scales without obeying the Schmid's law.It is concerned with the local stress enhancement in the macroscale while it is more closely related to the scarce dislocation sources in the microscale. Moreover, a wedge-shaped zone formed near the TB in the microscale ascribed to the limited specimen size. | L.L.Li Z.J.Zhang P.Zhang J.Tan J.B.Yang Z.F.Zhang | 2017 | Journal of Materials Science & Technology2017，33，7： | 3 |
| 3 | Rotational and translational domains of beta precipitate in aged binary Mg-Ce alloys显示文摘The structural evolution fromβ_(1)(Mg_(3)Ce)toβ(Mg_(12)Ce)precipitates,which takes place at the over-aged stage of binary Mg-Ce alloys,are investigated by high-angle annular dark-field scanning transmission electron microscopy.The structural transformation mainly occurs in the{111}_(β1)crystallographic planes,where the newly formedβlattices exhibit two categories of domain structures,namely rotational and translational domains.The rotational domain is composed of threeβdomains(β_(RA),β_(RB)andβ_(RC)),which are related by a 120°rotation with respect to each other around the 111_(β1)axis of theirβ_(1)parent phase.The{111}_(β1)crystallographic planes can provide four sets of sublattices with the same orientation for an initial nucleation ofβlattice.It leads to the formation of four translationalβdomains(β_(TA),β_(TB),β_(TC)andβ_(TD)),among which any two differ by a vector of 1/6112_(β1).We deduce theoretically that there exist twenty-fourβdomains during this transition.However,considering the interfacial misfit,only one-third of domains can grow up and eventually formsβribbon.Furthermore,a majority ofβribbons overlap partiallyβ_(1)plate,which is beneficial to relax interfacial strain amongβ,β_(1)andα-Mg matrix(α/β/β_(1)).The configuration of multipleβdomains can effectively regulate interfacial misfit ofα/βandβ/β_(1),which are responsible for enhancing the hardness and strength of Mg-Ce alloy.Additionally,this study aims to provide some clues to improve the over-aged performance of magnesium alloys by constructingβdomains and optimizing theα/β/β_(1)interface. | B.Z.Sun H.X.Zhang Y.Dong J.X.Ren Y.Tian G.M.Xie J.Tan Y.H.Sun Na Xiao | 2021 | Journal of Magnesium and Alloys2021，9，3： | 2 |
| 4 | Strengthening and deformation mechanism of high-strength CrMnFeCoNi high entropy alloy prepared by powder metallurgy显示文摘Multiphase CrMnFeCoNi high-entropy alloys(HEAs)were prepared by a powder metallurgy process com-bining mechanical alloying(MA)and vacuum hot-pressing sintering(HPS).The single-phase face-centered cubic(FCC)HEA powder prepared by MA was sintered into a bulk HEA specimen containing FCC phase matrix along with precipitated M 23 C 6 phase and nanoscaleσphase particles.When the sintering temper-ature was 1223 K,the ultimate strength reaches 1300±11.6 MPa,and the elongation exceeds 4%±0.6%.Microstructural characterization reveals that the formation of nanoscale particles and deformation twins play critical roles in improving the strain hardening(SH)ability.Prolonging the MA time promoted the formation of the precipitated phase and enhanced the SH ability by increasing the number of precip-itated particles.The SH capacity increases significantly with increasing sintering temperature,which is attributed to a significant enhancement in the twinning capacity due to grain growth and the reduced number ofσphase particles.Through systematic studies,the planar glide of dislocations was found to be the main mode of deformation,while deformation twinning appeared as an auxiliary deformation mode when the twinning stress was reached.Although the formation of precipitates leads to grain bound-ary and precipitation strengthening effects,crack initiation is more prominent owing to increased grain boundary brittleness around the precipitated M 23 C 6 phase.The prominence of crack initiation is a contra-diction that must be reconciled with regard to precipitation strengthening.This work serves as a useful reference for the preparation of high-strength HEA parts by powder metallurgy. | Y.Xing C.J.Li Y.K.Mu Y.D.Jia K.K.Song J.Tan G.Wang Z.Q.Zhang J.H.Yi J.Eckert | 2023 | Journal of Materials Science & Technology2023，，1： | 1 |
| 5 | Identification of vip3A‐type genes from Bacillus thuringiensis strains and characterization of a novel vip3A‐type gene显示文摘 | J.Liu F.Song J.Zhang R.Liu K.He J.Tan D.Huang | 2007 | Letters in Applied Microbiology2007，，4： | 1 |
| 6 | Environment-strategy Co-evolution and Co-alignment:A Staged Model of Chinese SOEs under Transition显示文摘 | J.Tan D.Tan | | 0，，02： | 1 |
| 7 | MAGNETIC PROPERTIES AND STRUCTURES OF NANO-CRYSTALLINE Fe-P-C-Mo-Cu-Si ALLOYS显示文摘MAGNETICPROPERTIESANDSTRUCTURESOFNANO-CRYSTALLINEFe-P-C-Mo-Cu-SiALLOYS￥Y.F.Gao,J.Tan;G.D.Liu;C.L.Zhang;T.LiuandR.ZMa(RapidlyQ... | Y.F. Gao,J.Tan G.D. Liu C.L.Zhang T.Liuand R.Z Ma (Rapidly Quenched Materials Research and Development Centre, Central Iron & Steel Research Institute,Beijing 100081, China)(Metal Physics Department, University of Science and Technology Beijing, Beijin | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，5： | 0 |
| 8 | 香港对于结核病的接触者检查是有用的显示文摘背景:香港政府结核病与胸部疾病中心的结核病控制规程。 目的:确定香港对结核病家庭接触者的检查结果。 设计:从在胸部疾病中心登记治疗的5757例中随机选择970首发病例,对其所有家庭接触者进行回顾性队列研究。 结果:在确定的2678名家庭接触者(首发病例的3倍)中,检查率为90%;发现41例活动性病例,比率为1720/100000(95%CI1238-2329)。比率在两端年龄组最高,≤5岁的儿童组为3604/100000(95%CI 990-3615),在>60岁年龄组的人群中为3547/100000(95%CI 1456-6489)。痰涂片和培养阳性的首发病例其接触者病例率最高,为2904/100000(95%CI 1869-4873);但细菌学为阴性病人的接触者病例率也高,为1478/100000(95%CI678-2789)。通过接触者追踪确定的阳性病例可能是源病例而不是继发病例。≤5岁的儿童结核菌素为阳性为8%,香港对所有的新生儿都予BCG接种,在过去的30年覆盖率为99%,很难估算这些儿童的感染率。 结论:香港作为结核病的中等负担地区,对接触者进行调查是主动发现活动性病例的一个非常有效的措施。 | K.Noertjojo C.M.Tam S.L.Chan J.Tan M.Chan-Yeung 王延莉 | 2002 | 国际结核病与肺部疾病杂志2002，，2： | 0 |
| 9 | Immunotherapy as maintenance treatment in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(mTNBC)is an aggressive disease associated with a poor prognosis as compared to other subtypes of breast cancer.Significant advances have been made in recent years with new approvals for PARP inhibitors for those patients who harbor germline BRCA mutations and immune checkpoint inhibitors for patients with programmed death ligand-1(PD-L1)expressing tumors.These therapies are associated with favorable toxicity profiles and improved health-related quality of life when compared with chemotherapy.Maintenance therapy,now recognized as the mainstay for patients with ovarian malignancies,takes advantage of the benefit of low-intensity therapies to suppress a disease over a prolonged period of time following maximal response to induction therapy.This strategy has been little explored in the treatment of mTNBC.Here,we briefly discuss the evidence to date lending credence to this treatment paradigm and examine the potential role of immunotherapy as maintenance in the management of mTNBC. | Tira J.Tan Jack J.Chan Rebecca A.Dent | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
| 10 | 通过分析配合力和SSR标记对热带和温带玉米近交种进行杂种优势分组显示文摘本研究之目的是分析25个热带玉米近交种和4个温带近交种产量性状的配合力以及这两者间的遗传关系,并通过比较配合力和SSR标记的分析结果来划分杂种优势组。本研究所用的25个热带玉米近交种是从5个主要热带玉米群体和地方种即Suwan 1。 | X.M.Fan J.Tan 谢国禄 | 2004 | 国外作物育种2004，23，4： | 0 |
| 11 | What Causes Some People to be Left-handed,and Why Are Fewer People Left-handed than Right-handed?显示文摘为什么右手成为大多数人的优势手?为什么左撇子虽然是少数,但依然存在呢?一项医学研究显示,在双亲均为左撇子的家庭,子女是左撇子的机率为50%。另一个证据是,左撇子的比例在某些家族中明显高于一般家族,说明用手的偏爱与遗传直接相关。 | J.Tan Manila Philippines 李伟 | 2004 | 当代外语研究2004，，12： | 0 |
| 12 | GO/MgO/Mg interface mediated strengthening and electromagnetic interference shielding in AZ31 composite显示文摘More requirements of electromagnetic interference(EMI) shielding performance are put forward for lightweight structural materials due to the development of aerospace and 5G communications. Herein, graphene oxide(GO) decorated with SnO_(2) coating is introduced as reinforcement into AZ31 Mg alloy. During the smelting process, the MgO layer is in situ gernerated at interface between GO and the molten Mg alloy matrix by consuming SnO_(2). In the solid state, such kind of interface structure can improve the GO-Mg interface bonding intensity,also significantly generate stacking faults. The AZ31 composite reinfoced by trace modified GO(0.1 wt%) exhibits high ultimate strength and almost the same elongation with AZ31 alloy. Compared with AZ31 alloy, the yield strength and ultimate tensile strength of composite are increased by 33.5% and 23.7%, respectively. Meanwhile, the multi-level electromagnetic reflection from the multi-layer structure of GO and the interface polarization caused by the MgO mid-layer can significantly improve EMI shielding performance. The appropriate interface design strategy achieves the effect of “two birds with one stone”. | Z.Y.Xu C.F.Fang C.J.Li R.Wang X.P.Zhang J.Tan Y.M.Wang | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
| 13 | Efficiency-enhanced reflective nanosieve holograms显示文摘Photon nanosieves,as amplitude-type metasurfaces,have been demonstrated usually in a transmission mode for optical super-focusing,display,and holography,but the sieves with subwavelength size constrain optical transmission,thus leading to low efficiency.Here,we report reflective photon nanosieves that consist of metallic meta-mirrors sitting on a trans-parent quartz substrate.Upon illumination,these meta-mirrors offer the reflectance of〜50%,which is higher than the transmission of visible light through diameter-identical nanoholes.Benefiting from this configuration,a meta-mirror-based reflective hologram has been demonstrated with good consistence between theoretical and experimental results over the broadband spectrum from 500 nm to 650 nm,meanwhile exhibiting total efficiency of〜7%.Additionally,if an additional high-reflectance layer is employed below these meta-mirrors,the efficiency can be enhanced further for optical anti-counterfeiting. | Samia Osman Hamid Mohammed 赵东 Syed Yasir Azeem Xiaoming Goh Shawn J.Tan Jinghua Teng 黄坤 | 2022 | Chinese Optics Letters2022，20，5： | 0 |
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