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| 1 | Biomechanics of ankle giving way:A case report of accidental ankle giving way during the drop landing test显示文摘Background:Several case studies observed that the lateral ankle sprain resulted from a sudden increase in ankle inversion accompanied by internal rotation.However,without sufficient ankle kinetics and muscle activity information in the literature,the detailed mechanism of ankle sprain is still unrevealed.The purpose of our case report is to present 2 accidental ankle giving way incidents for participants with chronic ankle instability(CAI)and compare to their normal trials with data of kinematics,kinetics,and electromyography(EMG).Case description:Two young female participants accidentally experienced the ankle giving way when landing on a 25°lateral-tilted force plate.3 D kinematics,kinetics,and muscle activity were recorded for the lower extremity.Qualitative comparisons were made between the giving way trials and normal trials for joint angles,angular velocities,moments,centers of pressure and EMG linear envelopes.Results:One participant’s giving way trial displayed increased ankle inversion and internal rotation angles in the pre-landing phase and at initial contact compared to her normal trials.Another participant’s giving way trial exhibited greater hip abduction angles and delayed activation of the peroneus longus muscle in the pre-landing phase versus her normal trials.Conclusion:A vulnerable ankle position(i.e.,more inverted and internally rotated),and a late activation of peroneus activity in the pre-landing phase could result in the ankle giving way or even sprains.A neutral ankle position and early activation of ankle evertors before landing may be helpful in preventing ankle sprains. | Yumeng Li Jupil Ko Shuqi Zhang Cathleen N.Brown Kathy J.Simpson | 2019 | Journal of Sport and Health Science2019，8，5： | 2 |
| 2 | Analysis of Ras‐induced oncogenic transformation of NIH‐3T3 cells using differential‐display 2‐DE proteomics显示文摘 | HongJi Robert L.Moritz Yu‐SamKim Hong‐JianZhu Richard J.Simpson | 2007 | ELECTROPHORESIS2007，，12： | 1 |
| 3 | The impact of chronic urticaria on the quality of life显示文摘 | B.F.O’DONNELL F.LAWLOR J.SIMPSON M.MORGAN M.W.GREAVES | 2008 | British Journal of Dermatology2008，，2： | 1 |
| 4 | Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor‐2 (FGF‐2)显示文摘 | A.SAHNI P. J.SIMPSON‐HAIDARIS S. K.SAHNI G. G.VADAY C. W.FRANCIS | 2007 | Journal of Thrombosis and Haemostasis2007，，1： | 1 |
| 5 | A double-moment multiple-phase four-class bulk ice scheme Part Ⅱ:Simulations of convective storms in different large-scale environments and comparisons with other bulk parameterizations显示文摘 | Ferrier B.S W.-K.Tao J.Simpson | | 0，，： | 1 |
| 6 | The tropical water and energy cycles in a cumulus ensemble model Part Ⅰ:Equilibrium climate显示文摘 | Sui C.-H K.-M.Lau W.-K.Tao J.Simpson | | 0，，： | 1 |
| 7 | The Goddard Cumulus Ensemble Model Part Ⅰ:Model description显示文摘 | Tao W.-K J.Simpson | | 0，，： | 1 |
| 8 | An icewater saturation adjustment显示文摘 | Tao W.-K J.Simpson M.McCumber | | 0，，： | 1 |
| 9 | Heating,moisture and water budgets of tropical and midlatitude squall lines:Comparisons and sensitivity to longwave radiation显示文摘 | Tao W.-K J.Simpson C.-H.Sui B.Ferrier S.Lang J.Scala M.-D.Chou and K.Pickering | | 0，，： | 1 |
| 10 | Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation显示文摘 | D. J.Humes J.Simpson J.Smith P.Sutton A.Zaitoun D.Bush A.Bennett J. H.Scholefield R. C.Spiller | 2012 | Neurogastroenterology & Motility2012，，4： | 1 |
| 11 | Preparation of Extracts from Yeast显示文摘 | Richard J.Simpson | | 0，，： | 1 |
| 12 | Review article: the current management of acute liver failure显示文摘 | D. G. N.CRAIG A.LEE P. C.HAYES K. J.SIMPSON | 2010 | Alimentary Pharmacology & Therapeutics2010，，3： | 1 |
| 13 | <sup>1</sup>H and <sup>19</sup>F nuclear magnetic resonance microimaging of water and chemical distribution in soil columns显示文摘 | Myrna J.Simpson André J.Simpson DieterGross ManfredSpraul William L.Kingery | 2009 | Environmental Toxicology and Chemistry2009，，7： | 1 |
| 14 | Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor‐2 (FGF‐2)显示文摘 | A.SAHNI P. J.SIMPSON‐HAIDARIS S. K.SAHNI G. G.VADAY C. W.FRANCIS | 2007 | Journal of Thrombosis and Haemostasis2007，，1： | 1 |
| 15 | Nutritional geometry framework of sucrose taste in Drosophila显示文摘Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste sensation.However,it remains unclear whether the balance of P and C influences the sweet taste sensitivity.Here,we use the nutritional geometry framework(NGF)to address the interaction of protein and carbohydrates on sweet taste using Drosophila as a model.Our results reveal that high-protein,low-carbohydrate(HPLC)diets sensitize to sweet taste and low-protein,high-carbohydrate(LPHC)diets desensitize sweet taste in both male and female flies.We further investigate the underlying mechanisms of the effects of two diets on sweet taste using RNA sequencing.When compared to the LPHC diet,the m RNA expression of genes involved in the metabolism of glycine,serine,and threonine is significantly upregulated in the HPLC diet group,suggesting these amino acids may mediate sweet taste perception.We further find that sweet sensitization occurs in flies fed with the LPHC diet supplemented with serine and threonine.Our study demonstrates that sucrose taste sensitivity is affected by the balance of dietary protein and carbohydrates possibly through changes in serine and threonine. | An-Qi Li Sha-Sha Li Ruo-Xin Zhang Xin-Yuan Zhao Zhi-Ying Liu Yun Hu Bei Wang G Gregory Neely Stephen J.Simpson Qiao-Ping Wang | 2023 | Journal of Genetics and Genomics2023，50，4： | 0 |
| 16 | 轻稀土区Nd和Ce核的超形变带显示文摘轻稀土区高自旋超形变的系统实验研究,首次发现了~133,134,137)Nd和^(131)Ce的超形变带,并证实和进一步研究了前已发现的^(135,136)Nd和^(132)Ce超形变带.本文叙述超形变带的实验寻找、指定和测量,并对所发现的超形变带的馈入、退激、转动惯量、相对强度和结构的系统性进行了讨论. | 罗亦孝 钟纪泉 A.Kirwan D.J.G.Love P.J.Nolan R.Wadsworth P.J.Bishop M.J.Godfrey R.Hughes A.N.James I.Jenkins S.M.Mullins J.Simpson D.J.Thornley K.L.Ying | 1989 | 高能物理与核物理1989，13，7： | 0 |
| 17 | Modern Corrosion Mapping of Storage Tank Bottoms--Notable Advancements in Critical Zone Coverage,Inspection Efficiency and Data Integrity显示文摘Every day,an NDT(Non-Destructive Testing)report will govern key decisions and inform inspection strategies that could affect the flow of millions of dollars which ultimately affects local environments and potential risk to life.There is a direct correlation between report quality and equipment capability.The more able the equipment is-in terms of efficient data gathering,signal to noise ratio,positioning,and coverage-the more actionable the report is.This results in optimal maintenance and repair strategies providing the report is clear and well presented.Furthermore,when considering tank floor storage inspection it is essential that asset owners have total confidence in inspection findings and the ensuing reports.Tank floor inspection equipment must not only be efficient and highly capable,but data sets should be traceable and integrity maintained throughout.Corrosion mapping of large surface areas such as storage tank bottoms is an inherently arduous and time-consuming process.MFL(magnetic flux leakage)based tank bottom scanners present a well-established and highly rated method for inspection.There are many benefits of using modern MFL technology to generate actionable reports.Chief among these includes efficiency of coverage while gaining valuable information regarding defect location,severity,surface origin and the extent of coverage.More recent advancements in modern MFL tank bottom scanners afford the ability to scan and record data sets at areas of the tank bottom which were previously classed as dead zones or areas not scanned due to physical restraints.An example of this includes scanning the CZ(critical zone)which is the area close to the annular to shell junction weld.Inclusion of these additional dead zones increases overall inspection coverage,quality and traceability.Inspection of the CZ areas allows engineers to quickly determine the integrity of arguably the most important area of the tank bottom.Herein we discuss notable developments in CZ coverage,inspection efficiency and data integrity that combines to deliver an actionable report.The asset owner can interrogate this report to develop pertinent and accurate maintenance and repair strategies. | Andrew J.Simpson Matthew A.Boat | 2024 | Journal of Civil Engineering and Architecture2024，18，3： | 0 |
| 18 | COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history显示文摘Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb titers.Methods:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 vaccine.All major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb serology.Results:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded exercise.However,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent manner.Both groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid antigens.nAbs increased significantly during exercise only in the hybrid immunity group.Conclusion:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity. | Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson | 2024 | Journal of Sport and Health Science2024，13，1： | 0 |
| 19 | Comparison of the‘Seattle’and‘International’Criteria Electrocardiogram Interpretation in Division II Female Collegiate Athletes:A Preliminary Study显示文摘Purpose A 12-lead electrocardiogram(ECG)is a screening tool to detect abnormalities that may predispose athletes to sud-den cardiac death.Newer standardized criteria have been introduced to better interpret ECG data,however this research has predominantly focused on male athletes.It is important to include female athletes in research to better define ECG character-istics in this population.The purpose of this study was to compare the Seattle and International Criteria ECG abnormalities in Division II female collegiate athletes of various ethnicities.Methods Fifty-six females(age 20.2±1.4 years;height 1.70±0.7 m;weight 69.5±8.9 kg)completed a resting 12-lead ECG protocol.ECG data was classified as‘normal’and‘abnormal’according to the parameters of each criterion and abnormal conditions were noted.Chi-square analysis was used to assess statistical comparisons between criteria.Results There was a significant difference in abnormal classifications as the total number of ECGs identified as abnormal using the Seattle Criteria decreased from 12(21.4%)to 2(3.6%)when using the International Criteria(P<0.05).African American athletes had a higher number of abnormal ECG’s compared to White and Latina athletes using the Seattle Criteria(P=0.03).Conclusions The International Criteria significantly reduces the total number of abnormal ECG readings in female collegiate athletes compared to the Seattle Criteria and did not overly identify African American athletes with abnormalities.Further research is necessary to expand on this study and clearly define criteria for female athletes of various ethnicities. | Ludmila Cosio-Lima N.Kumar Brooke L.Adlof J.Simpson A.Crawley Y.Lee | 2023 | Journal of Science in Sport and Exercise2023，5，3： | 0 |
| 20 | Low-protein diet accelerates wound healing in mice post-acute injury显示文摘Background:Wound healing processes are influenced by macronutrient intake(protein,carbohydrate and fat).The most favourable diet for cutaneous wound healing is not known,although highprotein diets are currently favoured clinically.This experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework,a nutrient modelling method,capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient intake.Methods:Two adjacent and identical full-thickness skin excisions(1 cm^(2))were surgically created on the dorsal area of male C57BL/6 mice.Mice were then allocated to one of 12 high-energy diets that varied in protein,carbohydrate and fat content.In select diets,wound healing processes,cytokine expression,energy expenditure,body composition,muscle and fat reserves were assessed.Results:Using the Geometric Framework,we show that a low-protein intake,coupled with a balanced intake of carbohydrate and fat is optimal for wound healing.Mice fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen production.These local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure,related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat depots.Conclusions:The results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets. | Jonathan J.Hew Roxanne J.Parungao Craig P.Mooney Julian K.Smyth Sarah Kim Kevin H.-Y.Tsai Huaikai Shi Cassandra Chong Renee C.F.Chan Beba Attia Caroline Nicholls Zhe Li Samantha M.Solon-Biet David G.Le Couteur Stephen J.Simpson Marc G.Jeschke Peter K.Maitz Yiwei Wang | 2021 | Burns & Trauma2021，9，1： | 0 |
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