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| 1 | Temozolomide resistance in glioblastoma multiforme显示文摘Temozolomide(TMZ)is an oral alkylating agent used to treat glioblastoma multiforme(GBM)and astrocytomas.However,at least 50%of TMZ treated patients do not respond to TMZ.This is due primarily to the over-expression of O6-methylguanine methyltransferase(MGMT)and/or lack of a DNA repair pathway in GBM cells.Multiple GBM cell lines are known to contain TMZ resistant cells and several acquired TMZ resistant GBM cell lines have been developed for use in experiments designed to define the mechanism of TMZ resistance and the testing of potential therapeutics.However,the characteristics of intrinsic and adaptive TMZ resistant GBM cells have not been systemically compared.This article reviews the characteristics and mechanisms of TMZ resistance in natural and adapted TMZ resistant GBM cell lines.It also summarizes potential treatment options for TMZ resistant GBMs. | Sang Y.Lee | 2016 | Genes & Diseases2016，3，3： | 26 |
| 2 | 依赖VS独立?中国消费者自我构念的地域和年龄差异及其对广告诉求偏好的影响显示文摘以往对于自我构念的研究普遍认为中国人更偏向依赖型自我。然而,随着社会和经济的日益发展,特别是改革开放和对外交流的深入,中国消费者的自我构念在不同年龄、不同地域上已逐渐发生变化。文章通过三个实验对这一问题进行了实证研究。结果显示:中国青少年的自我构念存在地域差异,即出生在大城市的青少年更偏向独立型自我,而出生在乡镇的青少年更偏向依赖型自我。此外,自我构念水平也存在年龄差异,相对于青少年而言,中年人更倾向于依赖型自我。在此基础上,文章还探讨了消费者的自我构念对不同广告诉求(趋利vs.避害)偏好的影响。 | 张红霞 丁瑛 Angela Y.Lee 徐菁 | 2013 | 营销科学学报(辑刊)2013，7，1： | 14 |
| 3 | 鼻咽癌调强放射治疗进展显示文摘调强放射治疗技术日趋成熟,鼻咽癌是最适于调强放射治疗的肿瘤之一。Ⅱ期临床研究结果显示,IMRT技术优于传统放射技术,IMRT技术提高了鼻咽癌的局部区域性控制率和总生存率,并改善了生存质量。准确勾画靶区和正常组织是保证鼻咽癌IMRT疗效的前提。本文将讨论鼻咽癌的靶区勾画、给量方式、临床治疗结果及治疗相关毒副反应。 | 孔琳 Nancy Y.Lee | 2008 | 中国癌症杂志2008，18，9： | 12 |
| 4 | Real-time forecasts of the COVID-19 epidemic in China from February 5th to February 24th,2020显示文摘The initial cluster of severe pneumonia cases that triggered the COVID-19 epidemic was identified inWuhan,China in December 2019.While early cases of the disease were linked to a wet market,human-to-human transmission has driven the rapid spread of the virus throughout China.The Chinese government has implemented containment strategies of city-wide lockdowns,screening at airports and train stations,and isolation of suspected patients;however,the cumulative case count keeps growing every day.The ongoing outbreak presents a challenge for modelers,as limited data are available on the early growth trajectory,and the epidemiological characteristics of the novel coronavirus are yet to be fully elucidated.We use phenomenological models that have been validated during previous outbreaks to generate and assess short-term forecasts of the cumulative number of confirmed reported cases in Hubei province,the epicenter of the epidemic,and for the overall trajectory in China,excluding the province of Hubei.We collect daily reported cumulative confirmed cases for the 2019-nCoV outbreak for each Chinese province from the National Health Commission of China.Here,we provide 5,10,and 15 day forecasts for five consecutive days,February 5th through February 9th,with quantified uncertainty based on a generalized logistic growth model,the Richards growth model,and a sub-epidemic wave model.Our most recent forecasts reported here,based on data up until February 9,2020,largely agree across the three models presented and suggest an average range of 7409e7496 additional confirmed cases in Hubei and 1128e1929 additional cases in other provinces within the next five days.Models also predict an average total cumulative case count between 37,415 and 38,028 in Hubei and 11,588e13,499 in other provinces by February 24,2020.Mean estimates and uncertainty bounds for both Hubei and other provinces have remained relatively stable in the last three reporting dates(February 7th e 9th).We also observe that each of the models predicts that the epidemic has reached saturation in both Hubei and other provinces.Our findings suggest that the containment strategies implemented in China are successfully reducing transmission and that the epidemic growth has slowed in recent days. | K.Roosa Y.Lee R.Luo A.Kirpich R.Rothenberg J.M.Hyman P.Yan G.Chowell | 2020 | Infectious Disease Modelling2020，5，1： | 12 |
| 5 | Pechini法制备的CeO_2纳米晶的晶化动力学显示文摘通过Pechini法制备CeO2粉末。XRD分析表明,该粉末在300℃下煅烧1h后成为纳米晶体。用DT 40热分析仪研究其晶化过程,在热分析过程中,CeO2的晶化过程符合Kissinger方程,计算得到其相变激活能为86.42kJ/mol,且其晶化过程所需能量比固相法的晶化过程所需能量显著降低。根据Qzawa方程得到,在250℃下Avrami指数n为1.5,频率因子为1.75×108。并由此推断该反应机理的形核过程为长程扩散控制型生长(初期阶段),从小尺寸开始的各种形状的生长形核率随时间下降。 | 张腾 唐电 张琼 邵艳群 Y.LEE | 2004 | 中国有色金属学报2004，14，6： | 4 |
| 6 | Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity显示文摘We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 histone methyltransferase activity.Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5(Kivalues <1 nmol/L) and function as antagonists of the MLL1 histone methyltransferase activity. | Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 7 | Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration显示文摘To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following i.v.administration of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) tumors.QWBA showed [3H]BMS-753493–derived radioactivity was extensively distributed to various tissues.The FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post dose.No selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after i.v.administration of the active epothilone,[3H]BMS-748285.LC–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after i.v.administration of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 administration.Those data were consistent with radioactivity determinations.Those results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor. | Hong Shen Lifei Wang Weiqi Chen Krista Menard Yang Hong Yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys Francis Y.Lee Jinping Gan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 8 | Effect of coating material and lubricant on forming force and surface defects in wire drawing process显示文摘A pilot wire drawing machine as well as wire end-pointing roller was developed. Using these machines, a wire drawing test for four different coating materials and two different lubricants was performed as the reduction ratio increased from 10% to 30%. Materials used for a substrate in this study are plain carbon steel (AISI1045) and ultra low carbon bainite steel. To compute the friction coefficient between the coating layer of wire and the surface of die for a specific lubricant, a series of finite element analyses were carried out. SEM observations were also conducted to investigate the surface defects of wire deformed. Results show that the behavior of drawing force varies with the lubricant-type at the initial stage of drawing. The powder-typed lubricant with a large particle causes the retardation of full lubrication on the entire contact surface and the local delamination of coating layer on the wire surface. As the flow stress of a substrate increases, the delamination becomes severe. | S.M.BYON S.J.LEE D.W.LEE Y.H.LEE Y.LEE | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 3 |
| 9 | G protein β3 subunit, interleukin‐10, and tumor necrosis factor‐α gene polymorphisms in Koreans with irritable bowel syndrome显示文摘 | H.‐j.Lee S.‐y.Lee J. E.Choi J. H.Kim I.‐k.Sung H. S.Park C. J.Jin | 2010 | Neurogastroenterology & Motility2010，，7： | 2 |
| 10 | Predicting scour beneath subsea pipelines from existing small free span depths under steady currents显示文摘An equation was developed to predict current-induced scour beneath subsea pipelines in areas with small span depths,S.Current equations for scour prediction are only applicable to partially buried pipelines.The existence of small span depths(i.e.S/D<0.3)are of concern because the capacity for scour is higher at smaller span depths.Furthermore,it is impractical to perform rectification works,such as installing grout bags,under a pipeline with a small S/D.Full-scale two-dimensional computational fluid dynamics(CFD)simulations were performed using the Reynolds-averaged Navier-Stokes approach and the Shear stress transport k-ωturbulence model.To predict the occurrence of scour,the computed maximum bed shear stress beneath the pipe was converted to the dimensionless Shields parameter,and compared with the critical Shields parameter based on the mean sediment grain size.The numerical setup was verified,and a good agreement was found between model-scale CFD data and experimental data.Field data were obtained to determine the mean grain size,far field current velocity and to measure the span depths along the surveyed pipe length.A trend line equation was fitted to the full-scale CFD data,whereby the maximum Shields parameter beneath the pipe can be calculated based on the undisturbed Shields parameter and S/D. | Jun Y.Lee Jasmin McInerney Remo Cossu Zhi Q.Leong Alexander L.Forrest | 2017 | Journal of Ocean Engineering and Science2017，2，2： | 2 |
| 11 | Experimental and finite element analysis for fracture of coating layer of galvannealed steel sheet显示文摘Mechanical properties of galvannealed (GA) steel sheet used for automotive exposed panel and predicted failure phenomenon of its coating layer were evaluated using finite element method. V-bending test was performed to understand better the fracture of coating layer of GA steel sheet during plastic deformation. Yield strength of the coating layer was calculated by using a relative difference between hardness of coating layer measured from the nano-indentation test and that of substrate. To measure shearing strength at the interface between substrate and coating layer, shearing test with two specimens attached by an adhesive was carried out. Using the mechanical properties measured, a series of finite element analyses coupled with a failure model was performed. Results reveal that the fracture of coating layer occurs in an irregular manner at the region where compressive deformation is dominant. Meanwhile, a series of vertical cracks perpendicular to material surface are observed at the tensile stressed-region. It is found that 0.26-0.28 of local equivalent plastic strain exists at the coating and substrate at the beginning of failure. The fracture of coating layer depends on ductility of the coating layer considerably as well. | S.I.KIM J.U.HER Y.C.JANG Y.LEE | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 2 |
| 12 | Unburned Carbon Loss in Fly Ash of CFB Boilers Burning Hard Coal显示文摘The unburned carbon loss in fly ash of circulating fluidized bed (CFB) boilers, most of which are burning active fuels such as lignite or peat, is normally very low. However, most CFB boilers in China usually burn hard coals such as anthracite and bituminous coal and coal wastes, so the carbon content in the fly ash from these boilers is higher than expected. This paper investigates the source of unburned carbon in the fly ash of CFB boilers burning hard coal through a series of field tests and laboratory investigations. The char behavior during combustion, including fragmentation and deactivation, which is related to the parent coal, has an important impact on the carbon burnout in CFB boilers. The research shows that char deactivation occurs during char burnout in fluidized bed combustion, especially for large particles of low rank coal. The uneven mixing of solids and air in the core region of the furnace also causes poor burnout of carbon in CFB fly ash. An index describing the volatile content (as dry ash free basis) over the heating value is proposed to present the coal rank. The coal combustion efficiency is shown to be strongly connected with this coal index. Several changes in the CFB boiler design are suggested to reduce the unburned carbon loss in the fly ash. | 吕俊复 王启民 黎永 岳光溪 Yam Y.Lee Baldur Eliasson 沈解忠 于龙 | 2003 | Tsinghua Science and Technology2003，8，6： | 2 |
| 13 | 基于遗传算法的火电单元机组多目标优化协调控制显示文摘作者提出了一种基于遗传算法的火电单元机组多目标优化协调控制策略。该策略通过改进的遗传算法进行多目标优化求解机组最优稳态控制量以得到最优设定值,从而完成多目标优化协调控制任务。改进的遗传算法采用十进制编码,规范化几何秩选择,混合交叉及均匀变异。仿真结果表明,在不同的运行目标下控制量的最优适应度函数都能快速收敛,遗传算法为多目标优化协调控制提供了有效的途径。 | 常江 Kwang Y.Lee | 2004 | 深圳职业技术学院学报2004，3，2： | 2 |
| 14 | Gene–gene interaction between interleukin‐4 and interleukin‐4 receptor α in Korean children with asthma显示文摘 | S.‐G.Lee B.‐S.Kim J.‐H.Kim S.‐Y.Lee S.‐O.Choi J.‐Y.Shim T.‐J.Hong S.‐J.Hong | 2004 | Clinical & Experimental Allergy2004，，8： | 1 |
| 15 | Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson’s disease显示文摘 | SergePrzedborski QipingChen MiquelVila Benoit I.Giasson RuthDjaldatti SlobodankaVukosavic José M.Souza VerniceJackson‐Lewis Virginia M.‐Y.Lee HarryIschiropoulos | 2008 | Journal of Neurochemistry2008，，2： | 1 |
| 16 | A Role for Interleukin‐10 in Alcohol‐Induced Liver Sensitization to Bacterial Lipopolysaccharide显示文摘 | Daniell B.Hill Nympha B.D’Souza Eun Y.Lee RavshanBurikhanov Ion V.Deaciuc Willem J. S.Villiers | 2006 | Alcoholism: Clinical and Experimental Research2006，，1： | 1 |
| 17 | The endogeneity of the Optimum Currency Area criteria in East Asia显示文摘 | Grace H Y.Lee M.Azali | | 0，，27： | 1 |
| 18 | 他汀治疗与心力衰竭患者住院、死亡的危险显示文摘背景:他汀治疗对心力衰竭患者的临床结果是否有益仍不清楚。
目的:评估开始他汀治疗与慢性心力衰竭患者发生死亡或住院危险的关系。
设计、地点和患者:于确诊心力衰竭的患者中进行的趋势校正队列研究。患者适合降脂治疗,但从1996年1月1日至2004年12月31日,在北加利福尼亚一家综合性保健救助系统治疗前未予他汀治疗。他汀的使用于药房数据库通过填写的门诊处方确定。
主要观测指标:在中位数2.4年的随访期间,心力衰竭患者之全因死亡和住院。在多变量校正潜在混淆因素后,我们检查了他汀治疗与总不良事件以及与有或无冠心病亚组不良事件的独立关系。
结果:在24598例以前未使用他汀的心力衰竭成年患者中,开始他汀治疗(n=12648;51.4%)的患者较为年轻,更可能为男性,更可能患心血管病、糖尿病和高血压。有8235例患者死亡。使用意向治疗方法,他汀的使用与心力衰竭患者发生死亡(使用他汀治疗组与未使用他汀治疗组年龄、性别校正后死亡率为14.5/100病人-年比25.3/100病人-年;校正后风险比,0.76[95%可信区间,0.72~0.80])和住院(年龄、性别校正后发生率为21.9/100病人-年比31.1/100病人-年;校正风险比,0.79[95%可信区间,0.74~0.85])的危险较低相关,即使在校正他汀使用趋势、胆固醇水平、其他心血管药物或潜在混淆因素后结果亦如此。他汀的使用与有或无已知冠心病患者发生不良结局之校正后风险较低相关。
结论:在已确诊心力衰竭且以前未用他汀的患者中,他汀的使用与有或无冠心病患者发生死亡或住院危险较低相关。 | Alan S.Go Wendy Y.Lee Jingrong Yang 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 1 |
| 19 | 如何将财务和非财务数据结合在一起显示文摘在企业内部管理方面,管理会计人员有时候会遇上一些棘手的问题。例如,如何把在经营周期上缩短百分之十的时间与降低百分之十二的修理成本相比较?能否在产品交货及时程度上提高的百分之五与在客户商品退回数量上减少百分之七进行比较?怎样才能使这些不相关的数据有机地结合起来,从而在报告中反映一个企业全面的商业经营成果?虽然目前对解决的方案还没有建立一致的意见,但是普遍认为,如果对非财务和财务绩效的计量缺乏适当的确认和计价,那么任何对企业经营进行的有效绩效评估都是不全面的。本文将提出一种解决方法,从而使不可比的数据转化为可利用的信息,为企业管理上的定量决策服务。这种方法旨在建立一个指数用来衡量非财务绩效在财务上的影响,该指数可以涉及许多方面,例如订货期至交货期的间隔、生产周期、生产效率、产品质量、交货的及时程度、市场渗透以及职员关系等。 | John Y.Lee 何怡宏 | 1993 | 财务与会计1993，，5： | 1 |
| 20 | A laparoscopic approach reduces short‐term complications and length of stay following ileocolic resection in Crohn’s disease: an analysis of outcomes from the NSQIP database显示文摘 | Y.Lee F. J.Fleming A.‐P.Deeb D.Gunzler S.Messing J. R. T.Monson | 2012 | Colorectal Disease2012，，5： | 1 |
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