|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars显示文摘New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly.Mycobacteria have a unique cell wall.Deletion of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG.The nat gene and its associated gene cluster are almost identical in sequence in M.bovis BCG and M.tuberculosis.The gene cluster is essential for intracellular survival of mycobacteria.We have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT activity.Here,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both M.bovis BCG and M.tuberculosis.The most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular survival.We also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity relationships.We conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved. | Isaac M.Westwood Sanjib Bhakta Angela J.Russell Elizabeth Fullam Matthew C.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim | 2010 | Protein & Cell2010，1，1： | 3 |
| 3 | Intestinal schistosomiasis in Uganda at high altitude(>1400 m):malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs显示文摘Background:Intestinal schistosomiasis is of public health importance in Uganda but communities living above 1400 m are not targeted for control as natural transmission is thought unlikely.To assess altitudinal boundaries and at-risk populations,conjoint malacological and epidemiological surveys were undertaken on Mount Elgon(1139 m-3937 m),in Fort Portal crater lakes and in the Rwenzori Mountains(1123 m-4050 m).Methods:Seventy freshwater habitats[Mount Elgon(37),Fort Portal crater lakes(23),Rwenzori Mountains(8)and Lake Albert(2)]were inspected for Biomphalaria species.Water temperature,pH and conductivity were recorded.A parasitological examination of 756 schoolchildren[Mount Elgon(300),Fort Portal crater lakes(456)]by faecal microscopy of duplicate Kato-Katz smears from two consecutive stool samples was bolstered by antigen(urine-CCA dipstick)and antibody(SEA-ELISA)diagnostic assays.Results:Biomphalaria spp.was found up to 1951 m on Mount Elgon and 1567 m in the Fort Portal crater lakes.Although no snail from Mount Elgon shed cercariae,molecular analysis judged 7.1%of snails sampled at altitudes above 1400 m as having DNA of Schistosoma mansoni;in Fort Portal crater lakes three snails shed schistosome cercariae.Prevalence of intestinal schistosomiasis as measured in schoolchildren by Kato-Katz(Mount Elgon=5.3%v.Fort Portal crater lakes=10.7%),CCA urine-dipsticks(18.3%v.34.4%)and SEA-ELISA(42.3%v.63.7%)showed negative associations with increasing altitude with some evidence of infection up to 2000 m.Conclusions:Contrary to expectations,these surveys clearly show that natural transmission of intestinal schistosomiasis occurs above 1400 m,possibly extending up to 2000 m.Using spatial epidemiological predictions,this now places some extra six million people at-risk,denoting an expansion of preventive chemotherapy needs in Uganda. | Michelle CStanton Moses Adriko Moses Arinaitwe Alison Howell Juliet Davies Gillian Allison EJames LaCourse Edridah Muheki Narcis BKabatereine J.Russell Stothard | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 4 | Towards interruption of schistosomiasis transmission in sub-Saharan Africa:developing an appropriate environmental surveillance framework to guide and to support‘end game’interventions显示文摘Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa,particularly common in rural populations living in impoverished conditions.With the scale-up of preventive chemotherapy,national campaigns will transition from morbidity-to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as‘end game’scenarios arise.Surprisingly,there are no international or national guidelines to do so in sub-Saharan Africa.Our article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance framework.In this context,we discuss how strategies need to be adapted and tailored to the local level to better guide and support future interventions through this transition.As detection of egg-patent infection in people becomes rare,careful sampling of schistosome larvae in freshwater and in aquatic snails with robust species-specific DNA assays will be required.Appropriate metrics,derived from observed prevalence(s)as compared with predetermined thresholds,could each provide a clearer insight into contamination-and exposure-related dynamics.Application could be twofold,first to certify areas currently free from schistosomiasis transmission or second to red-flag recalcitrant locations where extra effort or alternative interventions are needed. | J.Russell Stothard Suzy J.Campbell Mike Y.Osei-Atweneboana Timothy Durant Michelle C.Stanton Nana-Kwadwo Biritwum David Rollinson Dieudonne R.Eloundou Ombede Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 5 | Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar显示文摘School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden in pre-school aged children(PSAC)is currently overlooked.To assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in Marolambo District,Madagascar.Diagnosis included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears. | Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James M.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy JRussell Stothard Louis Andrianjaka Stephen A.Spencer | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 6 | Promising tumor‐associated antigens for future prostate cancer therapy显示文摘 | YongLi Paul J.Cozzi Pamela J.Russell | 2009 | Med. Res. Rev2009，，： | 1 |
| 7 | Structural long-pe-riod gratings in photonic crystal fibers显示文摘 | G.Kakarantzas T.A.Birks P.St. J.Russell | | 0，，12： | 1 |
| 8 | 美国制罐工业现状——金属罐与塑料罐之比较显示文摘封罐和检测系统给传统的罐头生产线提供了高速度、高效率和完整的产品。但目前,金属罐头生产线正受到包装设计方面的一种新势力——塑料罐的冲击。罐装食品和制罐工业历史悠久,以致于人们通常认为它们的存在是理所当然的。在1810年,一个名叫尼科尔斯·艾波特(Nicholas Appert)的法国人出版了第一部关于罐装方法的书并且介绍了一种新的食品储存方法。因此,罐装食品在当时或许是第一方便的食品。而塑料和塑料罐的出现展开了一场新的竞争,但在食品工业中,尤其是在饮料包装领域,金属罐仍然继续保持着强大的优势。实际上。 | MARGIE J.RUSSELL 张世荣 | 1989 | 包装与食品机械1989，7，3： | 1 |
| 9 | The effect of hydrological patterns and breeding‐season flooding on the numbers and distribution of wading birds in Everglades National Park显示文摘 | Gareth J.Russell Oron L.Bass Stuart L.Pimm | 2006 | Animal Conservation2006，，： | 1 |
| 10 | Fire performance of wood (Pinus radiata) treated with fire retardants and a wood preservative显示文摘 | D. C. O.Marney L. J.Russell R.Mann | 2008 | Fire Mater2008，，6： | 1 |
| 11 | Droplet-based bioprinting enables the fabrication of cell–hydrogel–microfibre composite tissue precursors显示文摘Composites offer the option of coupling the individual benefits of their constituents to achieve unique material properties,which can be of extra value in many tissue engineering applications.Strategies combining hydrogelswith fibre-based scaffolds can create tissue constructs with enhanced biological and structural functionality.However,developing efficient and scalable approaches to manufacture such composites is challenging.Here,we use a droplet-based bioprinting system called reactive jet impingement(ReJI)to integrate a cell-laden hydrogel with a microfibrous mesh.This system uses microvalves connected to different bioink reservoirs and directed to continuously jet bioink droplets at one another in mid-air,where the droplets react and form a hydrogel that lands on a microfibrous mesh.Cell–hydrogel–fibre composites are produced by embedding human dermal fibroblasts at two different concentrations(5×10^(6) and 30×10^(6) cells/mL)in a collagen–alginate–fibrin hydrogel matrix and bioprinted onto a fibre-based substrate.Our results show that both types of cell–hydrogel–microfibre composite maintain high cell viability and promote cell–cell and cell–biomaterial interactions.The lower fibroblast density triggers cell proliferation,whereas the higher fibroblast density facilitates faster cellular organisation and infiltration into the microfibres.Additionally,the fibrous component of the composite is characterised by high swelling properties and the quick release of calcium ions.The data indicate that the created composite constructs offer an efficient way to create highly functional tissue precursors for laminar tissue engineering,particularly for wound healing and skin tissue engineering applications. | Marcin Kotlarz Ana M.Ferreira Piergiorgio Gentile Stephen J.Russell Kenneth Dalgarno | 2022 | Bio-Design and Manufacturing2022，5，3： | 0 |
| 12 | 癌症的淋巴因子基因疗法显示文摘一、淋巴因子免疫疗法最近,重组淋巴因子的克隆、表达和大规模制备大大促进了辅助性T 细胞依赖性效应细胞的开发应用。尤其是重组IL-2已在体外用于诱导LAK 细胞,且能使转移性恶性黑色素瘤、肾细胞癌等某些肿瘤得以缓解。IL-2扩增后的TILS(肿瘤侵润性淋巴细胞),包括LAK 细胞前体、细胞毒性T 细胞和辅助性T 细胞,对同系肿瘤明显具有比LKA 细胞更强的细胞毒性,从而具有更大的疗效潜力。很多淋巴因子,包括IL-1、LL-4、IL-5、TNF、GM-CSF 和IFN—β在体外诱导LAK 细胞中与IL-2有协同作用。 | Stephe J.Russell 董增军 | 1991 | 国外医学(免疫学分册)1991，14，1： | 0 |
| 13 | 抗感染纺织材料在医疗及伤口敷料中的应用(英文)显示文摘以医用纺织品和纤维类伤口敷料为中心,回顾了国际上近几年在抗感染纺织品方面的研究进展.近年来,人们对银(包括纳米银)和铜在抗感染方面的应用非常重视.抗感染材料有较高的技术前景及应用价值,但其安全性、抗药性和对环境的影响也成为今天的课题和挑战.对于抗感染纺织材料,其光稳定性,以及磨损和洗涤对材料的功能的影响是人们关注的问题. | 王晓东 STEPHEN J.Russell | 2009 | 西安工程大学学报2009，23，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员