|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Monitoring coping style moderates emotional reactions to genetic testing for hereditary nonpolyposis colorectal cancer: a longitudinal study显示文摘 | S.Shiloh L.Koehly J.Jenkins J.Martin D.Hadley | 2008 | Psycho‐Oncology2008，，： | 1 |
| 2 | Metastatic osteosarcoma显示文摘 | Najat C.Daw Catherine A.Billups CarlosRodriguez‐Galindo M. BethMcCarville Bhaskar N.Rao Alvida M.Cain Jesse J.Jenkins Michael D.Neel William H.Meyer | 2006 | Cancer2006，，2： | 1 |
| 3 | Metastatic osteosarcoma显示文摘 | Najat C.Daw Catherine A.Billups CarlosRodriguez‐Galindo M. BethMcCarville Bhaskar N.Rao Alvida M.Cain Jesse J.Jenkins Michael D.Neel William H.Meyer | 2006 | Cancer2006，，2： | 1 |
| 4 | Immunology of a unique biological structure:the Echinococcus laminated layer显示文摘The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species.The resulting diseases,collectively termed echinococcoses,include major neglected tropical diseases of humans and livestock.Echinococcus larvae are outwardly protected by the laminated layer(LL),an acellular structure that is unique to this genus.The LL is based on a fibrillar meshwork made up of mucins,which are decorated by galactose-rich O-glycans.In addition,in the species cluster termed E.granulosus sensu lato,the LL features nano-deposits of the calcium salt of myo-inositol hexakisphosphate(Insp_(6)).The main purpose of our article is to update the immunobiology of the LL.Major recent advances in this area are(i)the demonstration of LL“debris”at the infection site and draining lymph nodes,(ii)the characterization of the decoy activity of calcium Inp6 with respect to complement,(iii)the evidence that the LL mucin carbohydrates interact specifically with a lectin receptor expressed in Kupffer cells(Clec4F),and(iv)the characterization of what appear to be receptor-independent effects of LL particles on dendritic cells and macrophages.Much information is missing on the immunology of this intriguing structure:we discuss gaps in knowledge and propose possible avenues for research. | Álvaro Díaz Anabella ABarrios Leticia Grezzi Camila Mouhape Stephen J.Jenkins Judith E.Allen Cecilia Casaravilla | 2023 | Protein & Cell2023，14，2： | 1 |
| 5 | 激活Toll样受体2可以促进胃癌细胞中的OXPHOS和糖酵解显示文摘目的:调查TLR家族中哪种TLR受体的配体依赖性激活可引起胃癌细胞的代谢重编程。方法:通过实时荧光定量PCR(RT-qPCR)和蛋白质印迹(WB)在一组人GC细胞中测量TLR家族成员的表达。通过进行Seahorse生物能测定以及测量L-乳酸和活性氧(ROS)的产生,确定激动剂对不同TLR(TLR2、4、9)诱导的人GC细胞的代谢变化;通过RT-qPCR在被刺激的GC细胞中分析了涉及氧化磷酸化和糖酵解的基因的表达;通过Western印迹表征SOD2的表达。结果:由合成分子或全病原体抗原激活的TLR2信号传导增强了胃癌细胞中高表达TLR2的细胞株的糖酵解活性和线粒体呼吸,而配体诱导的TLR4和TLR9活化抑制了线粒体呼吸或细胞外酸化率。同时,涉及葡萄糖代谢和氧化还原系统调节的基因,例如HIF1A,PFKFB3和SOD2,在TLRs下游被上调。结论:由配体诱导的特定TLRs的激活介导了人类GC细胞中不同的代谢表型。TLR2是唯一同时促进OXPHOS和糖酵解的家族成员,这可能导致肿瘤进展。 | 李雨哲 季承博 刘友东 顾琦晟 Brendan J.Jenkins 于亮 李继坤 | 2022 | 现代生物医学进展2022，22，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员