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| 1 | 利用基于淀粉酶的复合酶刺激仔猪的生长显示文摘在家禽尤其是肉鸡生产中添加糖酶(饲用酶)是降低肠道消化糜高黏性所带来的有害作用、提高日粮养分消化率的一种常规策略。这些糖酶还能使许多饲料原料得到利用,而其中的许多原料价格便宜但难于为动物消化和吸收。因此,糖酶使饲料的配制灵活多样,并且有助于降低饲料成本。 | 张贤群 J.Ignacio Fern á ndez | 2010 | 国外畜牧学(猪与禽)2010，，6： | 3 |
| 2 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 3 | Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma显示文摘 | J.Ignacio Herrero Bruno Sangro Jorge Quiroga Fernando Pardo Maite Herraiz Javier A. Cienfuegos Jesus Prieto | 2001 | Liver Transplantation2001，，7： | 1 |
| 4 | Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma显示文摘 | J.Ignacio Herrero Bruno Sangro Jorge Quiroga Fernando Pardo Maite Herraiz Javier A. Cienfuegos Jesus Prieto | 2001 | Liver Transplantation2001，，7： | 1 |
| 5 | A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis显示文摘 | Juan-Felipe Lucena J.Ignacio Herrero Jorge Quiroga Bruno Sangro Jesus Garcia-Foncillas Natalia Zabalegui Josu Sola Maite Herraiz Juan F. Medina Jesus Prieto | 2003 | Gastroenterology2003，，4： | 1 |
| 6 | The Redistributive Design Of Social Security Systems显示文摘 | J.Ignacio Conde - Ruiz Paola Profeta | | 0，，05： | 1 |
| 7 | Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein显示文摘 | Jan P.M. Langeveld S?ren Kamstrup Aase Uttenthal Bertel Strandbygaard Carmen Vela Kristian Dalsgaard Nico J.C.M. Beekman Rob H. Meloen J.Ignacio Casal | 1995 | Vaccine1995，，11： | 1 |
| 8 | Decoupled Double Synchronous Reference Frame PLL for Power Converters Control显示文摘 | Pedro Rodríguez Josep Pou Joan Bergas J.Ignacio Candela | | 0，，2： | 1 |
| 9 | Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes显示文摘Background:In-hospital mortality in patients with coronavirus disease 2019(COVID-19)is high.Simple prognostic indices are needed to identify patients at high-risk of COVID-19 health outcomes.We aimed to determine the usefulness of the CONtrolling NUTritional status(CONUT)index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital admission.Methods:Our study design is of a retrospective observational study in a large cohort of COVID-19 patients.In addition to descriptive statistics,a Kaplan-Meier mortality analysis and a Cox regression were performed,as well as receiver operating curve(ROC).Results:From February 5,2020 to January 21,2021,there was a total of 2969 admissions for COVID-19 at our hospital,corresponding to 2844 patients.Overall,baseline(within 4 days of admission)CONUT index could be scored for 1627(57.2%)patients.Patients’age was 67.3±16.5 years and 44.9%were women.The CONUT severity distribution was:194(11.9%)normal(0-1);769(47.2%)light(2-4);585(35.9%)moderate(5-8);and 79(4.9%)severe(9-12).Mortality of 30 days after admission was 3.1%in patients with normal risk CONUT,9.0%light,22.7%moderate,and 40.5%in those with severe CONUT(P<0.05).An increased risk of death associated with a greater baseline CONUT stage was sustained in a multivariable Cox regression model(P<0.05).An increasing baseline CONUT stage was associated with a longer duration of admission,a greater requirement for the use of non-invasive and invasive mechanical ventilation,and other clinical outcomes(all P<0.05).The ROC of CONUT for mortality had an area under the curve(AUC)and 95%confidence interval of 0.711(0.676-0746).Conclusion:The CONUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients. | Adrian K.Bengelloun Guillermo J.Ortega Julio Ancochea Ancor Sanz-Garcia Diego A.Rodriguez-Serrano Guillermo Fernandez-Jimenez Rosa Giron Elena Avalos Joan B.Soriano J.Ignacio de Ulibarri | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 10 | 在腐植酸存在的条件下动态模拟铜在贻贝类体内的富积显示文摘依据金属生物利用度模型,腐植酸对铜的络合作用有望降低水生生物对铜的生物利用度,就如生物配体模型(BLM)。这个模型在海洋无脊椎动物胚胎或是微藻类等不进食生物中得到了证实。但对于像紫贻贝等滤食性生物体,在腐植酸存在的条件下铜的富积较高,表明摄取的铜-腐植酸复合物可被吸收。 | Paula Sánchez-Marín Eneko Aierbe J.Ignacio Lorenzo 袁晓娜(译) | 2018 | 腐植酸2018，，1： | 0 |
| 11 | 如何提高家禽饲料的营养价值显示文摘包被谷物胚乳的细胞壁是由复杂的被公认为非淀粉多糖Non—starch polysm、charides,NSP)的碳水化合物组成。谷物以及其它常用饲料原料的细胞壁结构都很复杂,根据所评价的原料种类不同,其NSP的组成差异极大(表1)。 | 苏良科 J.Ignacio Fernandez David Gonzalez | 2012 | 国外畜牧学(猪与禽)2012，，6： | 0 |
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