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| 1 | Variation in the plant-mediated methane transport and its importance for methane emission from intact wetland peat mesocosms显示文摘Aims and Methods Vascular plants are known to influence the production,transport and oxidation of methane in wetland soils,but these processes are not well understood.using plants grown in intact peat cores,we compared the influence upon methane emissions of 20 forb and graminoid species from European wetlands.We measured plant-mediated transport of methane(conduit or chimney effect)using a novel agar-sealing technique that prevented methane exchange from the bare soil to the atmosphere.Important Findings the plant-mediated transport(chimney effect)represented between 30%and almost 100%of the total methane flux,with graminoids exhibiting greater internal transport than forbs.In general,plants with less dense root tissues and a relatively larger root volume exhibited a larger chimney effect.most species(12 out of 20)signif-icantly reduced methane emissions compared to bare soil and only one species,Succisa pratensis,increased them.We suggest that characterising vegetation in terms of plant functional traits and plant processes offers an effective method for estimating methane emis-sions from wetlands.However,we found no correlation between the magnitude of the chimney effect and the overall influence of different plant species on methane emissions.besides introducing a useful tool to study plant-mediated transport,this work suggests that characterising vegetation in terms of functional traits could improve estimates of methane emissions from wetlands,which in turn could help in designing mitigation strategies. | Gurbir S.Bhullar Peter J.Edwards Harry Olde Venterink | 2013 | Journal of Plant Ecology2013，6，4： | 1 |
| 2 | Modification of nitrogen remobilization, grain fill and leaf senescence in maize (Zea mays) by transposon insertional mutagenesis in a protease gene显示文摘 | Iain S.Donnison Alan P.Gay HowardThomas Keith J.Edwards DavidEdwards Caron L.James Ann M.Thomas Helen J.Ougham | 2006 | New Phytologist2006，，3： | 1 |
| 3 | Articulatory timing and the prosodic interpretation of syllable duration显示文摘 | Beckman M.E J.Edwards | | 0，，： | 1 |
| 4 | Gene body demethylation increases expression and is associated with self-pruning during grape genome duplication显示文摘A colchicine-induced autotetraploid grapevine exhibiting potentially valuable agronomic traits for grape production and breeding,including self-pruning,was identified.This study investigated DNA methylation variation and its role in gene expression during self-pruning in the autotetraploid grapevine.We used RNA-Seq to estimate differentially expressed genes between diploid and autotetraploid grapevine shoot tips.The genes showing increases in the autotetraploid were mainly related to stress response pathways,whereas those showing decreases in the autotetraploid were related to biological metabolism and biosynthesis.Whole-genome bisulfite sequencing was performed to produce single-base methylomes for the diploid and autotetraploid grapevines.Comparison between the methylomes revealed that they were conserved in CG and CHG contexts.In the autotetraploid grapevine,hypodifferentially methylated regions(DMRs)and hyper-DMRs in the gene body increased or decreased gene expression,respectively.Our results indicated that a hypo-DMR in the ACO1 gene body increased its expression and might promote self-pruning.This study reports that hypo-DMRs in the gene body increase gene expression in plants and reveals the mechanism underlying the changes in the modifications affecting gene expression during genome duplication.Overall,our results provide valuable information for understanding the relationships between DNA methylation,gene expression,and autotetraploid breeding in grape. | Luming Zou Wenwen Liu Zhan Zhang Everard J.Edwards Elias Kirabi Gathunga Peige Fan Wei Duan Shaohua Li Zhenchang Liang | 2020 | Horticulture Research2020，7，1： | 1 |
| 5 | Testing experimentally the effect of soil resource mobility on plant competition显示文摘Aims The volume of soil beyond a plant’s roots from which that plant is able to acquire a particular nutrient depends upon the mobility of that nutrient in the soil.For this reason it has been hypothesized that the strength of competitive interactions between plants vary with soil nutrient mobility.We aimed to provide an experimental test of this hypothesis.Methods We devised two experimental systems to investigate specifically the effect of nutrient transport rates upon intraspecific competition.In the first,the exchange of rhizosphere water and dissolved nutrients between two connected pots,each containing one plant,was manipulated by alternately raising and lowering the pots.In the second experiment,the roots systems of two competing plants were separated by partitions of differing porosity,thereby varying the plants’access to water and nutrients in the other plant's rhizosphere.In this second experiment,we also applied varying amounts of nutrients to test whether higher nutrient input would reduce competition when competition for light is avoided,and applied different water levels to affect nutrient concentrations without changing nutrient supply.Important findings In both experiments,lower mobility reduced competitive effects on plant biomass and on relative growth rate(RGR),as hypothesized.In the second experiment,however,competition was more intense under high nutrient input,suggesting that low nutrient supply rates reduced the strength of the superior competitor.Competitive effects on RGR were only evident under the low water level,suggesting that under lower nutrient concentrations,competitive effects might be less pronounced.Taken together,our results provide the first direct experimental evidence that a reduction in nutrient mobility can reduce the intensity of competition between plants. | Stefanie Wilberts Matthias Suter Nina Walser Peter J.Edwards Harry Olde Venterink Dieter Ramseier | 2014 | Journal of Plant Ecology2014，7，3： | 0 |
| 6 | The Utility of Voided Urine Samples as a Proxy for the Vaginal Microbiome and for the Prediction of Bacterial Vaginosis显示文摘Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological health.However,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained clinician.In contrast,urine sample collection is routine and noninvasive and does not require involvement of a clinician.We sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal microbiome.Paired urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic profiling.We examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal microbiomes.Moreover,the relative abundances of common vaginal taxa were linearly correlated with those in the paired urogenitalmicrobiomes.These similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical applications.Finally,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis. | Bin Zhu Christopher Diachok Laahirie Edupuganti David J.Edwards Jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine Vladimir Lee Myrna G.Serrano Gregory A.Buck | 2022 | Infectious Microbes & Diseases2022，4，4： | 0 |
| 7 | TAOS/STEP卫星显示文摘1996年3月13日,自主运行生存能力/空间试验实验平台(TAOS/STEP)技术卫星由金牛座(TAURUS)火箭从范登堡空军基地发射到105°倾角的近圆形轨道上。这颗卫星有两个用途:1)试验多途径获取快速一跟踪模块化卫星的新概念;2)在空间试验一套菲利普实验室的有效载荷。TAOS有效载荷包括MICROCOSM公司的自主导航系统(MANS),两个巴恩斯工程公司的双圆锥扫描器,两台霍尼韦尔的通用超大规模集成电路(VHSIC)星载计算机,一台洛克韦尔全球定位系统接收器,一个军标1553B数据总线,两个激光敏感器和一个雷达敏感器。有效载荷的实验周期大约一年半,尽管STEP卫星的惯性测试元件、TAOS有效负载的一台通用VHSIC星载计算机以及GPS接收器的射频链路出了故障,但实验仍取得极大的成功。 | David J.Edwards Robert W.Hosken 陈小军 | 1997 | 控制工程(北京)1997，，1： | 0 |
| 8 | Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy显示文摘The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during pregnancy.Vaginal lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm birth.If the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse events.In this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early pregnancy.Relationships between the vaginal microbiome and the vaginal lipidome have not been previously reported.Results from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and cytokines.While the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host. | Sophonie Jean Bernice Huang Hardik I.Parikh David J.Edwards J.Paul Brooks Naren Gajenthra Kumar Nihar U.Sheth Vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe Jerome F.StraussIII Myrna G.Serrano Jennifer M.Fettweis Kimberly K.Jefferson Gregory A.Buck | 2019 | Infectious Microbes & Diseases2019，1，2： | 0 |
| 9 | Molecular phylogenetic analysis reveals six new species of Diaporthe from Australia显示文摘t Six new species of Diaporthe,D.beilharziae on Indigofera australis,D.fraxini-angustifoliae on Fraxinus angustifolia subsp.oxycarpa,D.litchicola on Litchi chinensis,D.nothofagi on Nothofagus cunninghamii,D.pascoei on Persea americana and D.salicicola on Salix purpurea from Australia are described and illustrated based on morphological characteristics and molecular analyses.Three of the new species no longer produced sporulating structures in culture and two of these were morphologically described from voucher specimens.Phylogenetic relationships of the new species with other Diaporthe species are revealed by DNA sequence analyses based on the internal transcribed spacer(ITS)region,and partial regions of theβtubulin(BT)and translation elongation factor 1-alpha(TEF). | Y.P.Tan J.Edwards K.R.E.Grice R.G.Shivas | 2013 | Fungal Diversity2013，，4： | 0 |
| 10 | Osteonecrosis of the jaw in a patient with acute myeloid leukemia,who received azacitidine显示文摘The first case of osteonecrosis of the jaw(ONJ)related to azacitidine therapy was reported.A 64-year-old male with acute myeloid leukemia,who received 5-azacitidine,presented with pain and purulence of the right second premolar.An unsuccessful endodontic therapy resulted in dental extraction 6 months later.The post-extraction non-healing socket was managed with antibiotics and multiple surgical debridements without response.ONJ stage 2 was diagnosed 12 months after the initial symptoms of pain and purulence and was managed conservatively.Currently the patient is still receiving 5-azacitidine therapy,while ONJ remains asymptomatic.This case highlights the presence of alveolar bone disease prior to the appearance of ONJ.Osteonecrosis in chemotherapy,although rare,may increase as long-term survival of cancer patients,who receive those medications increases.Health care professionals need to be alert,while collaboration with an experienced oral/dental oncologist would be beneficial to the patient. | Ourania Nicolatou-Galitis Dimitra Galiti Maria Moschogianni Sotirios Sachanas Beatrice J.Edwards Cesar A.Migliorati Gerassimos Pangalis | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
| 11 | The role of inflammation in cerebral aneurysms显示文摘The natural history of unruptured intracranial aneurysms(IAs)is poorly understood.At present,risk factors for aneurysm rupture are limited to demographics and rudimentary anatomic features of the aneurysm.The first sign of aneurysm destabilization and rupture may be subarachnoid hemorrhage,a potentially devastating brain injury with high morbidity and mortality.An emerging body of literature suggests a complex inflammatory cascade likely promotes aneurysm wall remodeling and progressive ballooning of the arterial wall,ultimately terminating in aneurysm rupture.These events likely begin with hemodynamic,flow‑related endothelial injury;the injured endothelium stimulates inflammation,including the recruitment and transmigration of inflammatory cells,particularly macrophages.Various proteases are secreted by the inflammatory infiltrate,resulting in degradation of the extracellular matrix and the structural changes unique to IAs.Detailed understanding of these inflammatory processes may result in(1)early identification of patients at high risk for aneurysm rupture,perhaps via arterial wall imaging,and(2)targeted,noninvasive therapies to treat or even prevent cerebral aneurysms. | Ali H.Turkmani Nancy J.Edwards Peng R.Chen | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 0 |
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