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您的检索式：作者名="David J.Edwards"
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| 1 | The Utility of Voided Urine Samples as a Proxy for the Vaginal Microbiome and for the Prediction of Bacterial Vaginosis显示文摘Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological health.However,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained clinician.In contrast,urine sample collection is routine and noninvasive and does not require involvement of a clinician.We sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal microbiome.Paired urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic profiling.We examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal microbiomes.Moreover,the relative abundances of common vaginal taxa were linearly correlated with those in the paired urogenitalmicrobiomes.These similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical applications.Finally,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis. | Bin Zhu Christopher Diachok Laahirie Edupuganti David J.Edwards Jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine Vladimir Lee Myrna G.Serrano Gregory A.Buck | 2022 | Infectious Microbes & Diseases2022，4，4： | 0 |
| 2 | TAOS/STEP卫星显示文摘1996年3月13日,自主运行生存能力/空间试验实验平台(TAOS/STEP)技术卫星由金牛座(TAURUS)火箭从范登堡空军基地发射到105°倾角的近圆形轨道上。这颗卫星有两个用途:1)试验多途径获取快速一跟踪模块化卫星的新概念;2)在空间试验一套菲利普实验室的有效载荷。TAOS有效载荷包括MICROCOSM公司的自主导航系统(MANS),两个巴恩斯工程公司的双圆锥扫描器,两台霍尼韦尔的通用超大规模集成电路(VHSIC)星载计算机,一台洛克韦尔全球定位系统接收器,一个军标1553B数据总线,两个激光敏感器和一个雷达敏感器。有效载荷的实验周期大约一年半,尽管STEP卫星的惯性测试元件、TAOS有效负载的一台通用VHSIC星载计算机以及GPS接收器的射频链路出了故障,但实验仍取得极大的成功。 | David J.Edwards Robert W.Hosken 陈小军 | 1997 | 控制工程(北京)1997，，1： | 0 |
| 3 | Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy显示文摘The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during pregnancy.Vaginal lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm birth.If the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse events.In this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early pregnancy.Relationships between the vaginal microbiome and the vaginal lipidome have not been previously reported.Results from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and cytokines.While the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host. | Sophonie Jean Bernice Huang Hardik I.Parikh David J.Edwards J.Paul Brooks Naren Gajenthra Kumar Nihar U.Sheth Vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe Jerome F.StraussIII Myrna G.Serrano Jennifer M.Fettweis Kimberly K.Jefferson Gregory A.Buck | 2019 | Infectious Microbes & Diseases2019，1，2： | 0 |
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