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| 1 | Targeted sequencing supports morphology and embryo features in resolving the classification of Cyperaceae tribe Fuireneae s.l.显示文摘Molecular phylogenetic studies based on Sanger sequences have shown that Cyperaceae tribe Fuireneae s.l.is paraphyletic.However,taxonomic sampling in these studies has been poor,topologies have been inconsistent,and support for the backbone of trees has been weak.Moreover,uncertainty still surrounds the morphological limits of Schoenoplectiella,a genus of mainly small,amphicarpic annuals that was recently segregated from Schoenoplectus.Consequently,despite ample evidence from molecular analyses that Fuireneae s.l.might consist of two to four tribal lineages,no taxonomic changes have yet been made.Here,we use the Angiosperms353 enrichment panel for targeted sequencing to(i)clarify the relationships of Fuireneae s.l.with the related tribes Abildgaardieae,Eleocharideae,and Cypereae;(ii)define the limits of Fuireneae s.s.,and(iii)test the monophyly of Fuireneae s.l.genera with emphasis on Schoenoplectus and Schoenoplectiella.Using more than a third of Fuireneae s.l.diversity,our phylogenomic analyses strongly support six genera and four major Fuireneae s.l.clades that we recognize as tribes:Bolboschoeneae stat.nov.,Fuireneae s.s.,Schoenoplecteae,and Pseudoschoeneae tr.nov.These results are consistent with morphological,micromorphological(nutlet epidermal cell shape),and embryo differences detected for each tribe.At the generic level,most sub-Saharan African perennials currently treated in Schoenoplectus are transferred to Schoenoplectiella.Our targeted sequencing results show that these species are nested in Schoenoplectiella,and their treatment here is consistent with micromorphological and embryo characters shared by all Schoenoplectiella species.Keys to recognized tribes and genera are provided. | Julian R.Starr Pedro Jiménez-Mejías Alexandre R.Zuntini Étienne Léveillé-Bourret Ilias Semmouri Muthama Muasya William J.Baker Grace E.Brewer Niroshini Epitawalage Isabel Fairlie Félix Forest Izai A.B.Sabino Kikuchi Lisa Pokorny Isabel Larridon | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
| 2 | A Study of Juvenile Theft显示文摘 | Harry J.Baker Fred J.Decker Arthur S.Hill | | 0，，02： | 1 |
| 3 | A new classification of Cyperaceae (Poales) supported by phylogenomic data显示文摘Cyperaceae(sedges)are the third largest monocot family and are of considerable economic and ecological importance.Sedges represent an ideal model family to study evolutionary biology due to their species richness,global distribution,large discrepancies in lineage diversity,broad range of ecological preferences,and adaptations including multiple origins of C4 photosynthesis and holocentric chromosomes.Goetghebeur′s seminal work on Cyperaceae published in 1998 provided the most recent complete classification at tribal and generic level,based on a morphological study of Cyperaceae inflorescence,spikelet,flower,and embryo characters,plus anatomical and other information.Since then,several family-level molecular phylogenetic studies using Sanger sequence data have been published.Here,more than 20 years after the last comprehensive classification of the family,we present the first family-wide phylogenomic study of Cyperaceae based on targeted sequencing using the Angiosperms353 probe kit sampling 311 accessions.In addition,62 accessions available from GenBank were mined for overlapping reads and included in the phylogenomic analyses.Informed by this backbone phylogeny,a new classification for the family at the tribal,subtribal,and generic levels is proposed.The majority of previously recognized suprageneric groups are supported,and for the first time,we establish support for tribe Cryptangieae as a clade including the genus Koyamaea.We provide a taxonomic treatment including identification keys and diagnoses for the 2 subfamilies,24 tribes,and 10 subtribes,and basic information on the 95 genera.The classification includes five new subtribes in tribe Schoeneae:Anthelepidinae,Caustiinae,Gymnoschoeninae,Lepidospermatinae,and Oreobolinae. | Isabel Larridon Alexandre R.Zuntini Étienne Léveillé-Bourret Russell L.Barrett Julian R.Starr AMuthama Muasya Tamara Villaverde Kenneth Bauters Grace E.Brewer Jeremy J.Bruhl Suzana M.Costa Tammy L.Elliott Niroshini Epitawalage Marcial Escudero Isabel Fairlie Paul Goetghebeur Andrew LHipp Pedro Jiménez-Mejías Izai ABSabino Kikuchi Modesto Luceño JoséIgnacio Márquez-Corro Santiago Martín-Bravo Olivier Maurin Lisa Pokorny Eric HRoalson Ilias Semmouri David A.Simpson Daniel Spalink WWayt Thomas Karen L.Wilson Martin Xanthos Félix Forest William J.Baker | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
| 4 | Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration显示文摘 | MargaretSperow Raymond B.Berry Ildar T.Bayazitov GuoZhu Suzanne J.Baker Stanislav S.Zakharenko | 2012 | The Journal of Physiology2012，，4： | 1 |
| 5 | p53:a tumor suppressor hiding in plain sight显示文摘It is a pleasure to join the other authors in this issue to hon orDr Arnold Levi neand the remarkable impact of his research.Our paths crossed with Amie's when our genetic analyses of colorectal cancers led us to investigate the p53 gene and identify it as a tumor suppressor gene.p53 was initially identified by Arnie and others as an oncogene and tumor antigen,nearly a decade before its role as a tumor suppressor gene was revealed.We fondly remember Arnie visiting our lab,and we visiting his,to discuss the implications of the genetic alterations our group identified in human cancers and how we could work together to investigate the voluminous new questions these mutations raised. | Suzanne J.Baker Bert Vogelstein | 2019 | Journal of Molecular Cell Biology2019，11，7： | 0 |
| 6 | Drug Repurposing for the Treatment of Mycobacterium abscessus Infections显示文摘With the ever-increasing burden of antimicrobial resistance,the demand to introduce countermeasures becomes increasingly critical.The urgency of this need is intensified by the void in antibiotic discovery,with the identification of novel compounds declining with time.Of increasing concern is Mycobacterium abscessus,which displays high levels of intrinsic resistance that lead to poor success rates,even after lengthy drug regimens.Research tackling these issues is now focused on the repurposing of preexisting drugs for antimycobacterial use,facilitating the discovery of antimicrobial compounds amidst a crisis where novel antibiotics are sparse.Part of this includes the use of combination treatments,whereby coadministration of synergistic compounds can reduce dose requirements and slow the progression of antimicrobial resistance in the long term.In this review,we will introduce the current therapeutic options for M.abscessus and provide insight into why treatment is so burdensome.We will also compile the current updates within drug repurposing for this pathogen,including the use of unconventional agents such as antimalarial drugs,the repositioning of antitubercu-losis candidates and the repurposing of preexisting antibiotics,including the application of combination regimens.In addition,the in vitro drug screening platforms used in their discovery will be appraised,with the view of highlighting potential future perspectives that may help increase physiological relevance.This review provides a timely appraisal of the future of M.abscessus treatment. | Emily J.Baker Antonia Molloy Jonathan A.G.Cox | 2023 | Infectious Microbes & Diseases2023，5，3： | 0 |
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