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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | The effect of postoperative wound infections on functional outcome following intra-articular calcaneal fractures显示文摘 | Backes M Schep N W Luitse J S | 2015 | Archives of Orthopaedic&Trauma Surgery2015，135，8： | 1 |
| 4 | Proteins of the outer layer of the vitelline membrane of hen's eggs显示文摘 | BACK J BAIN J VADEHRA D | 1982 | Biochem Biophys Acta1982，70，5： | 1 |
| 5 | Pre-and post-casino impact of residents' perception显示文摘 | Lee C K Back K J | 2003 | Annals of Tourism Research2003，30，4： | 1 |
| 6 | Traditional tonsillectomycompared with bipolar radiofrequency thermal ablationtonsillectomy in adults: a pilot study 显示文摘 | Back L Paiolheimo M Ylikoski J | 2001 | Arch Otolaryngol HeadNeck Surg2001，127，： | 1 |
| 7 | High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York hospital显示文摘 | Back E E O'Grady E J Back J D | 2012 | Antimicrob Agents Chemother2012，56，： | 1 |
| 8 | Study on the membrane filtration of mash with particular respect to the quality of wort and beer显示文摘 | Schneider J Krottenthaler M Back W | 2005 | Journal of the Institute of Brewing2005，111，4： | 1 |
| 9 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 ( RRMI ) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Lee J J Maeng C H Back S K | 2010 | Lung Cancer2010，70，2： | 1 |
| 10 | Antioxidant activities of a new lignan and a neolignan from Saururus chinensis 显示文摘 | Lee W S Back Y I Kim J R etal | 2004 | Bioorg Med Chem Lett2004，14，22： | 1 |
| 11 | Chronic infusion of CDNF prevents 6-OHDA-indueed deficits in a rat model of Parkinson's disease显示文摘 | Voutilainen MH Back S Peranen J | 2011 | Exp Neurol2011，228，1： | 1 |
| 12 | UPR pathways combine to pre- vent hepatic steatosis caused by ER stress - mediated suppression of transcriptional master regulators 显示文摘 | Rutkowski DT Wu J Back SH | 2008 | Dev Cell2008，15，6： | 1 |
| 13 | Comparative study of wear-resistant DLC and fullerene- like CNx coatings produced by pulsed laser and filtered cathodic arc depositions 显示文摘 | Voevodin A Jones J Back T | 2005 | Surface Coatings Technology2005，197，1： | 1 |
| 14 | Constitutively wilted 1,a member of the rice YUCCA gene family,is required for maintaining water homeostasis and an appropriate root to shoot ratio显示文摘 | Woo Y M Park H J Su'udi M Yang J I Park J J Back K Park Y M An G | 2007 | Plant Molecular Biology2007，65，1： | 1 |
| 15 | Laser-plasma interactions in ignition-scale hohlraum plasmas显示文摘 | MacGOWAN B J AFEYAN B B BACK C A | 1996 | Physics of Plasmas1996，3，5： | 1 |
| 16 | A review of convention and meeting management research 1990 - 2003 显示文摘 | Lee M J Back K J | 2005 | Journal of Convention & Event Tourism2005，7，2： | 1 |
| 17 | Antiatherosclerotic activity of inhibitors of 3-hydroxy-3methylglutaryl coenzyme A reductase in cholesterol-fed rabbits:a biochemical and morphological evaluation显示文摘 | Thomas MA Bacan Michelle J Mazur Sandra Back Mueller | 1994 | Atherosclerosis1994，111，： | 1 |
| 18 | Detailed measurements of a diffusive supersonic wave in a radiatively heated foam显示文摘 | Back C A Bauer J D Landen O L | 2000 | Phys Rev Lett2000，84，2： | 1 |
| 19 | Volatile components in flavour concentrates from crayfish processing waste显示文摘 | Cha Y J Back H H Hsieh T C Y | 2006 | Journal of the Science of Food and Agriculture2006，58，2： | 1 |
| 20 | Adding robustness to nominal output-feedback controllers for uncertain nonlinear systems:A nonlinear version of disturbance observer 显示文摘 | Back J Shim H | 2008 | Automatica2008，44，10： | 1 |
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