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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Biodegradation and brain tissue reaction to poly(DL- lactide- co- glycolide) microspheres显示文摘 | Menei P Daniel V Benoit J P | 1992 | Biomaterials1992，14，： | 2 |
| 3 | Sulfide controls on mercury speciation and the bioavailability in sediment pore waters显示文摘 | BENOIT J M GILMOUR C C MASON R P | 1999 | Environmental Science & Technology1999，33，： | 1 |
| 4 | Convection-enhanced delivery of nanoparticles for the treatment for brain tumors 显示文摘 | ALLARD E PASSIRANI C BENOIT J P | 2009 | Biomaterials2009，30，12： | 1 |
| 5 | A pharmaco-genetics study of the human glucuronosyltransferase UGT1A4显示文摘 | BENOIT B MARIE O ADAM J P | 2009 | Pharm Genomics2009，19，12： | 1 |
| 6 | Rapid improvement in sleep apnoea of acromegaly after short-term treatment with somatostatinanalogue SMS 201-995显示文摘 | Chanson P Timsit J Benoit O | 1986 | Lancet1986，1，8492： | 1 |
| 7 | West wind climate simulation of the mountainous Yukon 显示文摘 | PINARD J P BENOIT R YU W A | 2005 | Atmosphere-Ocean2005，43，3： | 1 |
| 8 | Multiple-object auctions with budget constrained bidders 显示文摘 | Benoit J P Krishna V | 2001 | Review of Economic Studies2001，68，1： | 1 |
| 9 | The diagnostic use of the second oscillatory potential in clinical electroretinography 显示文摘 | Lachapelle P Benoit J Little JM | 1989 | Doc Ophthalmol1989，73，： | 1 |
| 10 | Surface Characterization of Poly(a-hydroxy acid)Microspheres Prepared by A Solvent Evaporation/Extraction Process显示文摘 | F Boury H MarChais J P Benoit J E Proust | 1997 | Biomaterials1997，18，2： | 1 |
| 11 | Behavior of mercury in the Patuxent River estuary显示文摘 | Benoit J M Gilmour C C Mason R P | 1998 | Biogeochernistry1998，40，23： | 1 |
| 12 | A neural mechanism mediating the impact of episodic prospection on farsighted decisions显示文摘 | BENOIT R G GILBERT S J BURGESS P W | 2011 | Journal of Neuroscience2011，，18： | 1 |
| 13 | Evaluation of the solitary pulmonary nodule by positron emission tomography imaging显示文摘 | Bury T Dowlati A Panlus P Corhay J L Benoit T Kayembe J M | 1996 | Eur Respir J1996，9，： | 1 |
| 14 | An adaptive accuracy-based a posteriori error estimator 显示文摘 | GROSSE I R KATRAGADDA P BENOIT J | 1992 | Finite Elements in Analysis and Design1992，12，： | 1 |
| 15 | Mercury Cycling in the Allequash Creek Watershed,Northern Wisconsin显示文摘 | Krabbenhoft D P Benoit J M Babiarz C L | 1995 | Water Air Soil Pollut1995，80，： | 1 |
| 16 | Seasonal Influences on Partitioning and Transport of Total and Methylmercury in Rivers from Contrasting Watersheds显示文摘 | Babiarz C L Hurley J P Benoit J M | 1998 | Biogeochemistry1998，41，： | 1 |
| 17 | Effect of mixing energy levels during batch mixing of cement slurries显示文摘 | Hibert A P Kellingary D J Benoit V | 1995 | SPE Drilling & Completion1995，10，1： | 1 |
| 18 | Ibuprofen-loaded ethylcellulose microspheres:Analysis of the matrix structure by thermal analysis显示文摘 | Dubernet C Rouland J C Benoit J P | 1991 | Pharm Sci1991，80，： | 1 |
| 19 | Characterization of drug-loaded poly(d,l-lactide)microspheres显示文摘 | Benita S Benoit J P Puisieux F | 1984 | J Pharrn Sci1984，73，12： | 1 |
| 20 | Sulfide controls on mercury speciation and bioavailability to methylating bacteria in sediment pore waters显示文摘 | Benoit J M Gilmour C C Mason R P | 1999 | Environmental Science & Technology1999，33，6： | 1 |
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