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| 1 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | Gastric food retention at endoscopy is associated with severity of liver cirrhosis显示文摘BACKGROUND Gastrointestinal symptoms are prevalent in patients with cirrhosis.Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis.However,the contributing factors have not been fully elucidated.Retained gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity.Therefore,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver disease.Additionally,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of cirrhosis.AIM To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated factors.METHODSWe performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated factors.RESULTSOverall, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P = 0.015), opioid use (P = 0.004),Child-Pugh class C (24.1% Child-Pugh class C vs 6.4% Child-Pugh class A, P =0.007), and lower platelet count (P = 0.027). On multivariate logistic regressionanalysis, in addition to the presence of cirrhosis (adjusted OR = 5.83;95%CI: 2.32-14.7, P < 0.001), diabetes mellitus (types 1 and 2 combined) (OR = 2.34;95%CI:1.08-5.06, P = 0.031), opioid use (OR = 3.08;95%CI: 1.29-7.34, P = 0.011), andChild-Pugh class C (OR = 4.29;95%CI: 1.43-12.9, P = 0.01) were also associatedwith a higher likelihood of food retention on EGD.CONCLUSIONCirrhotics have a higher frequency of retained food at EGD than non-cirrhotics.Decompensated cirrhosis, defined by Child-Pugh class C, is associated with ahigher likelihood of delayed gastric emptying. | David B Snell Shirley Cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul J Christos Arun B Jesudian | 2019 | World Journal of Hepatology2019，11，11： | 2 |
| 4 | Advanced gain-scheduling techniques for uncertain systems 显示文摘 | APKARIAN P ADAMS R J | 1998 | IEEE Trans Control System Technology1998，6，1： | 2 |
| 5 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 6 | Induction of Ovulation with Pulsatile Luteinising Hormone Releasing Hormone显示文摘 | Mason P Adams J Morris DV | 1984 | Br Med J (Clin Res Ed)1984，288，6412： | 1 |
| 7 | Hepatitis B surface antigen presentation and HLA-DRB1*-lessons from twins and peptide binding studies显示文摘 | Kruger A Adams P Hammer J | 2005 | Clin Exp Immunol2005，140，： | 1 |
| 8 | Rheological character-ization of animal fats and their mixtures with#2 fuel oil显示文摘 | GOODRUM J W GELLER D P ADAMS T T | 2003 | BiomassBioenergy2003，24，3： | 1 |
| 9 | Pharmacokinetlcs of floffenicol in veal calves 显示文摘 | VARMA K J ADAMS P E POWERS T E | 1986 | J Vet Phannacol Therap1986，9，： | 1 |
| 10 | A Vibration Technique for Non-Destructively Assessing the Integrity of Structures显示文摘 | Adams R D Cawley P Pye C J | 1978 | Journal of Mechanical Engineering Science1978，，20： | 1 |
| 11 | A universal PCR primer for detection members of Potyviride and its use to examine the taxonomic status of several members of the family显示文摘 | CHEN J CHEN J P ADAMS M J | 2001 | Archives of Virology2001，146，4： | 1 |
| 12 | Guidelines for the early management of adults with ischemic stroke : a guideline from the American Heart Association/American Stroke Association Stroke Coun- cil, Clinical Cardiology Council, Cardiovascular Radiology and Inter- vention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists 显示文摘 | Adams H P Jr del-Zoppo G Alberts M J | 2007 | Stroke2007，38，5： | 1 |
| 13 | Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation显示文摘 | ADAMS M J AHUJA K D K GERAGHTY D P | | 0，，06： | 1 |
| 14 | Nucleotide sequence, polymorphism, and evolution of ovine MHC class Ⅱ DQA genes 显示文摘 | Scott P C Gogolin-Ewens K J Adams T E | 1991 | Immunogenetics1991，34，2： | 1 |
| 15 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 16 | Guidelines for the early management of adults withischemic stroke: a guideline from the American Heart Association/American Stroke Association StrokeCouncil, ClinicalCardiology Council, CardiovascularRadiology and Inter vent ion Council, and theAtherosclerotic Peripheral VascularDisease andQualityof CareOutcomeinResearchlnterdisciplinary Working Groups:the American Academy of Neurologyaffirms the value of this guideline as an educationaltool for neurologists 显示文摘 | ADAMS H P JR DEL ZOPPO G ALBER TS M J | 2007 | Stroke2007，38，： | 1 |
| 17 | A vibration technique for non - destructive assessing the integrity of structures显示文摘 | Cawley P Pye C J Stone B J | 1978 | Journal of Mechanical Engineering Science1978，20，： | 1 |
| 18 | A pharmaco-genetics study of the human glucuronosyltransferase UGT1A4显示文摘 | BENOIT B MARIE O ADAM J P | 2009 | Pharm Genomics2009，19，12： | 1 |
| 19 | A vibration technique for non-destructively assessing the integrity of structures显示文摘 | ADAMS R D CAWLEY P PYE C J | | 0，，2： | 1 |
| 20 | Assodation between surges of follicle stimulating hormone and the emergence of follicular waves in heifers显示文摘 | Adams G P Matted R L Kastellc J Pt | 2002 | J Reprod Fertil2002，94，： | 1 |
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