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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Ultrasound assisted extraction of anthraquinones from roots of Morinda citrifolia显示文摘 | Surasak H Prasert P Art iwan S | 2006 | Ult rasonic Sonochem2006，13，6： | 1 |
| 3 | Study on the continuous production of (R) - ( - ) - phenylacetylcarbinol in an enzyme - membrane reactor显示文摘 | Iwan P Goetz G Sehnfitz S | 2001 | J Mol Catal B: Enzymatic2001，11，： | 1 |
| 4 | Effect of IL-lbeta,TNF-alpha and IL-4 on complement regulatory protein mRNA expression in human articular chondrocytes显示文摘 | HYC A OSIECKA -IWAN A STRZELCZYK p | 2003 | Int J Mol Med2003，11，1： | 1 |
| 5 | On the formulations of strain space plasticity pith multiple loading surfaces显示文摘 | Yoder P J Iwan W D | 1981 | ASME Journal of Applied Mechanics1981，48，4： | 1 |
| 6 | Dietary cis- and trans- monounsaturated and saturated FA and plasma lipids and lipoproteins in men 显示文摘 | Judd JT Baer D J Clevidence BA Kris-Etherton P Muesing RA Iwane M | 2002 | Lipids2002，37，2： | 1 |
| 7 | Studies on the continuous production of (R)-(-)-phenylacetylcarbinol in an enzymem显示文摘 | Iwan P Goetz G Schmitz S | 2001 | Journal of Molecular Catalysis B2001，11，3： | 1 |
| 8 | Response envelope statistics for non-linear oscillators with random-excitation显示文摘 | Iwan W D Spanos P T | 1978 | Journal of Applied Mechanics1978，45，： | 1 |
| 9 | On the formulation of strain-space plasticity with multiple loading surfaces显示文摘 | Yoder P J Iwan W D | 1981 | J Appl Mech Trans ASME1981，48，4： | 1 |
| 10 | Effect of IL - 1beta, TNF- alpha and IL- 4 on complement regulatory protein mRNA expression in human articular chondrocytes 显示文摘 | Hye A Osiecka - Iwan A Strzelezyk P | 2003 | Int J Mol Med2003，11，1： | 1 |
| 11 | Curvature-dependent Surface Tension and Nucleation Theory显示文摘 | Jurn W P S Gutzow Iwan Schmelzer Jr Jurn | 1996 | Journal of Colloid and Interface Science1996，178，2： | 1 |
| 12 | Curvature-dependent surface tension and nucleation theory显示文摘 | Jurn W P S Iwan G Jurn S J | 1996 | Colloid and Interface Science1996，178，： | 1 |
| 13 | The recent convergence on the NW Borneo Wedge-A crustal-scale gravity gliding evidenced from GPS显示文摘 | Francois S Iwan H Manuel P | 2013 | Geophysical Journal International2013，193，2： | 1 |
| 14 | Generation of a Recombinant Chimeric Newcastle Disease Virus Vaccine That Allows Serological Differentiation between Vaccinated and Infected Animal 显示文摘 | Peeters B P H Olav S DE leeuw Iwan V | 2001 | Vaccine2001，19，： | 1 |
| 15 | Populationbased surveillance for hospitalizations associated with respiratory syncytial virus,influenza virus,and parainfluenza viruses among young children显示文摘 | Iwane M K Edwards K M Szilagyi P G | 2004 | Pediatrics2004，113，17： | 1 |
| 16 | Population-based surveillance for hospitalizations associated with respiratory syncytial vi- res, influenza virus, and Parainfluenza viruses among young children 显示文摘 | IWANE M K EDWARDS K M SZILAGYI P C | 2004 | Pediatrics2004，113，6： | 1 |
| 17 | Computational aspects of random vibration analysis 显示文摘 | Spanos P D Iwan W D | 1978 | Journal of the Engineering Mechanics DivisionASCE1978，104，6： | 1 |
| 18 | Population-based surveillance for hospitalizations associated with respiratory syncytial virus,influenza virus,and parainfluenza viruses among young children显示文摘 | Iwane M K Edwards K M Szilagyi P G | 2004 | Pediatrics2004，113，6： | 1 |
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