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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | The Use of Preoperative Endoscopic Tattooing in Laparoscopic Colorectal Cancer Surgery for Endoscopically Advanced Tumors: A Prospective Comparative Clinical Study显示文摘 | Ivan Arteaga-González MD Antonio Martín-Malagón MD Eudaldo M. López-Tomassetti Fernández MD Javier Arranz-Durán MD Adolfo Parra-Blanco MD David Nicolas-Perez MD Enrique Quintero-Carrión MD Hermogenes Díaz Luis MD Angel Carrillo-Pallares MD PhD | 2006 | World Journal of Surgery2006，，4： | 2 |
| 3 | Structure and Deformational Behavior of Poly(vinylidene fluoride) Hard Elastic Films显示文摘 | Ivan D Viii B Viktor L Galina E | 2007 | Acta chimica slovenica2007，54，： | 1 |
| 4 | Expression of PEA3/EIAF/ETV4, an Ets-related transcription factor,in breast tumors: positive links to MMP2,NRG1 and CGB expression 显示文摘 | IVAN BI CHE SENG L TOZLU IGOR GIRAULT | 2004 | Carcinogenesis2004，25，： | 1 |
| 5 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 6 | Design and mechanism of action of a novel bacteria-selective antimicrohial peptide from the cell-penetrating peptide Pep-1显示文摘 | Zhu W L Ivan H L Park J | 2006 | Biochemical and Biophysical Research Communications2006，849，2： | 1 |
| 7 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 8 | Posttranscriptional Gene Silencing in Transgenic Sugarcane显示文摘 | Ivan L Ingelbrecht James E Irvine T Erik Mirkov | 1999 | Plant Physiol1999，119，4： | 1 |
| 9 | A discrete ele- ment model to investigate sub-surface damage due to surface polishing 显示文摘 | Ivan Iordanoff Battentier A Charles J L | 2008 | Tribology Int2008，41，11： | 1 |
| 10 | Trust Factors Influencingthe Adoption of Internet-based InterorganizationalSystems 显示文摘 | Lai Ivan K W Tong VinyW L Lai Donny C F | 2011 | ElectronicCommerce Researchand Applications2011，10，1： | 1 |
| 11 | Carotid artery resection and reconstruction in patients with squamous cell carcinomas of the neck 显示文摘 | Ivan L Paczona R Czigner J | 1999 | Eur Arch Otorhinolaryngol1999，256，3： | 1 |
| 12 | Beyond creditworthy : Microcredit and Informal credit in the United States 显示文摘 | Ivan L Michelle P | 1998 | Journal of Developmental Entrepreneurship1998，，13： | 1 |
| 13 | Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the yon Hippel-Lindau protein 显示文摘 | Ohh M Park C W Ivan M Hoffman M A Kim T Y Huang L E | 2000 | Nat Cell Biol2000，2，： | 1 |
| 14 | Laser doppler velocimeter for laboratory training 显示文摘 | IVAN V F BORIS L D ALEXEY S K | 2002 | Seventh international conference on education and training in optics and photonics New York Proceedings of SPIE2002，4588，： | 1 |
| 15 | ALA (5-aminolevulinic acid)-induced protoporphyrin Ⅸ fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer显示文摘 | Csanady M Kiss JG Ivan L | 2004 | Eur Arch Otorhinolaryngol2004，261，： | 1 |
| 16 | Calix arene-porphyrin Conjugates as Versatile Molecular Receptors for Anions 显示文摘 | Miroslav D Pavel L Ivan S | 2003 | Organic Letters2003，5，2： | 1 |
| 17 | Giant versus small porphyry copper deposits of Cenozoic age in northern Chile: adakitic versus normal calc-alkaline magmatism显示文摘 | Roberto Oyarzun Alvaro Márquez Javier Lillo Ivan López Sergio Rivera | 2001 | Mineralium Deposita2001，，8： | 1 |
| 18 | Absence of the interstial cells of cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jamesom F Ivan D Zhiyue L | 2005 | J Gastrointestinal Surg2005，9，1： | 1 |
| 19 | The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors 显示文摘 | L'ubos D Ivan V Radoslav Z | 2012 | Exper Biol Med2012，237，1： | 1 |
| 20 | Absence of the interstitial ceils of Cajal in patients with clinical findings显示文摘 | Jameson F Ivan D Zhiyue L | 2005 | J Gastroen- terol Surg2005，9，3： | 1 |
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