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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | Liquid-Liquid Equilibria of Water + Butyric Acid + Nonanol Ternary System显示文摘Liquid-liquid equilibrium (LLE) data for the water + butyric acid + nonanol system have been determined experimentally at the temperatures of 298.15 K, 308.15 K and 318.15 K. Tie-line compositions were correlated by Othmer-Tobias method. The universal quasichemical functional group activity coefficient (UNIFAC) and modified UNIFAC methods were used to predict the phase equilibrium in the system using the interaction parameters between CH3, CH2, COOH, OH and H2O functional groups. Distribution coefficients and separation factors were evaluated for the immiscibility region. | S.Ismail Kirbaslar Sema Yüksel Erol Ince Ismail Boz | 2004 | Chinese Journal of Chemical Engineering2004，12，5： | 2 |
| 3 | Intravenous amiodarone for shortterm treatment of refractory ventricular tachycardia or fibrillation显示文摘 | Nalos Pc Ismail Y Pappas JM | 1991 | Am Heart J1991，122，： | 1 |
| 4 | An optimized method for measurement of gamma - H2AX in blood mononuclear and cultured cells 显示文摘 | Muslimovic A Ismail IH Gao Y | 2008 | Nature Protocols2008，3，7： | 1 |
| 5 | Intravenous amiodarone for short term treatment of refractory ventricular tachycardia or fibrillation显示文摘 | Nalos PC Ismail Y Pappas JM | 1991 | Am Heart J1991，122，6： | 1 |
| 6 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 7 | Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes显示文摘 | Newby AC George SJ Ismail Y | 2009 | Thromb Haemost2009，101，6： | 1 |
| 8 | Macrophage microvesicles induce macrophage differentiation and miR 223 transfer 显示文摘 | Ismail N Wang Y Dakhlallah D | 2013 | Blood2013，121，6： | 1 |
| 9 | The growth and flowering of some annual Ohm- mental on coconut dust显示文摘 | Awang Y Ismail M | 1997 | Aeta Hort1997，450，： | 1 |
| 10 | Fuzzy clustering for symbolic data显示文摘 | Sonbaty Y E Ismail M A | 1998 | IEEE Fuzzy Systems1998，6，2： | 1 |
| 11 | Supplemental L-arginine attenuates pulmonary hypertension syndrome (ascites) in broilers显示文摘 | Wideman R F Kirby Y K Ismail M | 1995 | Poult Sci1995，74，2： | 1 |
| 12 | Pulmonary tuberculosis-a review of clinical features and diagnosis in 232 cases显示文摘 | ISMAIL Y | 2004 | Med J Malaysia2004，59，1： | 1 |
| 13 | The growth and flowering of some an-nual ornamentals on coconut dust 显示文摘 | AWANG Y ISMAIL M | 1997 | Acta Horticulturae1997，450，： | 1 |
| 14 | Transcranial magnetic stimulation of degenerating brain:a comparison of normal aging,Alzheimer's,Parkinson's and Huntington's disease显示文摘 | Ljubisavljevic M R Ismail F Y Filipovic S | | 0，，： | 1 |
| 15 | Direct micro joining of flexible printed circuit and metal electrode by pulsed Nd:YAG laser显示文摘 | ISMAIL M I S OKAMOTO Y OKADA A UNO Y UEOKA K | | 0，，03： | 1 |
| 16 | Coronary CTangiographic characteristics of culprit lesions in acute coro-nary syndromes not related to plaque rupture as defined byoptical coherence tomography and angioscopy显示文摘 | OZAKI Y OKUMURA M ISMAIL T F | 2011 | Eur HeartJ2011，32，22： | 1 |
| 17 | Ruptured dissecting aneu- rysms arising from non-vertebral arteries of the posterior circulation: endovascular treatment perspective 显示文摘 | Ismail O Celal C Baki Y | 2009 | Diagn Interv Radiol2009，15，： | 1 |
| 18 | The growth and flowering of some annual orna- mentals on coconut dust显示文摘 | AWANG Y ISMAIL M | 1997 | Acta Holt1997，450，： | 1 |
| 19 | Production planning optimization with physical programming显示文摘 | Messac A Batayneh W M Ismail Y A | 2002 | Engineering Optimization2002，34，4： | 1 |
| 20 | DTT: Direct truncation of the transfer function-An alterative to moment matching for tree structured interconnect 显示文摘 | Ismail Y I Friedman E G | 2002 | IEEE Transactions on ComputerAided Design of Integrated Circuits and Systems2002，21，2： | 1 |
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