|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 3 | Ultraviolet DIAL measurements of 03 profiles in regions of spatially inhomogeneous aerosols 显示文摘 | Browell E V Ismail S Shipley S T | 1985 | Applied Optics1985，24，17： | 1 |
| 4 | The mental health of UK Gulfwar veterans:phase 2 of a two phase cohort study显示文摘 | Ismail K Kent K Brugha T | 2002 | BMJ2002，325，7364： | 1 |
| 5 | Purification and a dehydrin involved in chilling tolerance during seedling emergence of cowpea 显示文摘 | Ismail A M Hall A E Close T partial characterization of Sequence and their Biology J | 1999 | Plant Physiology1999，120，1： | 1 |
| 6 | Comparative lipid peroxidation,antioxidant defense systems and praline content in roots cultivars differing in salt tolerance显示文摘 | Tijen D Ismail T | 2005 | Environmental and Experimental Botany2005，53，： | 1 |
| 7 | Does exogenous glycinebetaine affect antioxidative system of rice seedlings under NaCl treatment?显示文摘 | Tijen Demiral Ismail Türkan | 2004 | Journal of Plant Physiology2004，，10： | 1 |
| 8 | Different antioxidant defense responses to salt stress during germination and vegetative stages of endemic halophyte Gypsophila oblanceolata Bark 显示文摘 | Askim H S Ismail T Zehra O T | 2012 | Environmental and Experimental Botany2012，77，： | 1 |
| 9 | Effect of different Al contents on the microstructure tensile and wear properties of Zn - based alloy 显示文摘 | EI- khair M T Daoud A Ismail A | 2004 | Mater Letter2004，58，11： | 1 |
| 10 | Effect of operating conditions on the physical and chemical CO 2 absorption through the PVDF hollow fiber membrane contactor显示文摘 | MANSOURIZADEH A ISMAIL A F MATSUURA T | 2010 | Journal of Membrane Science2010，353，1： | 1 |
| 11 | Newfrontiers in obstructive sleep apnoea显示文摘 | Najib T Ayas Allen A J Hirsch Ismail Laher | 2014 | Clinical Science2014，127，4： | 1 |
| 12 | Preparation and barrier properties of SPEEK/Cloisite 15A/TAP nanocomposite membrane for DMFC application显示文摘 | Jaafar J Ismail A F Matsuura T | 2009 | J Membr Sci2009，345，12： | 1 |
| 13 | Differential responses of antioxidative enzymes and lipid peroxidation to salt stress in salt-tolerant Plantago maritime and salt-sensitive Plantago media显示文摘 | Hediye S Ismail T Susumu T | 2007 | Physiologia Plantarum2007，131，： | 1 |
| 14 | Effect of modified PVDF hollow fiber submerged ultrafiltration membrane for refinery wastewater treatment 显示文摘 | Yuliwati E Ismail A F Matsuura T Kassim M A Abdullah M S | 2011 | Desalination2011，283，： | 1 |
| 15 | An experimental determination of pressure drops in the flow of low density spherical capsule train inside horizontal pipes 显示文摘 | Deniz U Ismail T | 2006 | Experimental Thermal and Fluid Science2006，30，3： | 1 |
| 16 | Coronary CTangiographic characteristics of culprit lesions in acute coro-nary syndromes not related to plaque rupture as defined byoptical coherence tomography and angioscopy显示文摘 | OZAKI Y OKUMURA M ISMAIL T F | 2011 | Eur HeartJ2011，32，22： | 1 |
| 17 | Cure and tear properties of ENR--25/ SMR--L and SMR--L blends显示文摘 | Ismail H Poh E T | 2000 | European Polymer Journal2000，36，11： | 1 |
| 18 | Morphological and separation performance study of polysulfone/titanium dioxide(PSF/TiO2 ) ultrafiltration membranes for humic acid removal显示文摘 | Harold N A A Ismail A F Matsuura T | 2011 | Desalination2011，273，1： | 1 |
| 19 | A mobile robot path plan- ning using genetic algorithm in static environment 显示文摘 | Ismail A L T Sheta A Al-Weshah M | 2008 | Journal of Computer Science2008，4，4： | 1 |
| 20 | Comparison of plasma and erythrocyte membrane fatty acid cmimsitions in patients with end-stage renal disease and type 2 diabetes mellitus显示文摘 | Erdim S Ismail K Serkan T | 2014 | Chemistryand Physics of Lipids2014，178，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员