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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 3 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 4 | The effect of storage temperature on histamine production and the freshness of yellowfin tuna(Tbunnus albacares)显示文摘 | Nejib G Moza A A Ismail M A | 2005 | Food Research International2005，38，2： | 1 |
| 5 | Evaluation and adaptation of the EGM2008geopotential model along the Northern Nile Valley,Egypt:case study显示文摘 | DAWOD G MOHAMED H ISMAIL S | 2010 | Journal of Surveying Engineering2010，136，1： | 1 |
| 6 | Persistent hyperinsulinaemic hypoglycaemia of infancy: 15 years' experience at the Royal Children's Hospital (RCH), Melbourne 显示文摘 | Ismail D Werther G | 2005 | Pediatr Endocrinol Metab2005，18，11： | 1 |
| 7 | Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland显示文摘 | Khan OY Fu G Ismail A | 2006 | Mol Endocrino12006，20，3： | 1 |
| 8 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 9 | A cryptosystem based on elementary cellular auto-mata显示文摘 | Abdo A A Lian S G Ismail I A | 2013 | Commun Nonlinear Sci Nu- mer Simul2013，18，1： | 1 |
| 10 | SLOOP dissociates myosin IIA fila- ments and focal adhesion sites to reduce cell adhesion and enhance cell migration显示文摘 | Du M Wang G Ismail TM | 2012 | J Biol Chem2012，287，15： | 1 |
| 11 | The effects of different extraction solvents of varying polarities on polyphenols of orthosiphon stamineus and evaluation of the free radical -scavenging activity显示文摘 | AKOWUAH G A ISMAIL Z NORHAYATII | 2005 | Food Chemistry2005，93，： | 1 |
| 12 | Persistent hyperinsulinaemic hypogly- eaemia of infancy: 15 years' experience at the Royal Chil- dren's Hospital (RCH), Melbourne 显示文摘 | Ismail D Werther G | 2005 | J Pediatr Endoerinol Metab2005，18，11： | 1 |
| 13 | Crack Damage Detection of Reinforced Concrete Beams Using Local Stiffness Indicator显示文摘 | ISMAIL Z ONG A Z C RAHMAN A G A | 2011 | Scientific Research and Essays2011，6，34： | 1 |
| 14 | 源自天然席夫碱的过渡金属配合物在分光光度法测天然水中的Fe(Ⅲ)的应用(英文)显示文摘描述了一种新颖、简便的合成含五齿配位基的大环席夫碱配体的方法,制备和表征了该席夫碱的1∶1包合物。用化学和光谱学方法测定了标题配合物的组成,认为在所有配合物中配位金属原子取八面体结构。数据表明:配体起O2N4六齿结构而每个环绕金属原子在八面体环境中。配合物的红外和1H NMR光谱符合中心金属原子的配位结果。用分光光度法测定了配合物的稳定常数。用共轭余量法(CR method)计算了在热分解的不同阶段配合物活化的动力学和热力学参数。此外,用抑菌圈直径法筛选了配体及其金属配合物抑制细菌和真菌的能力。用回收率试验研究了天然螯合配体在不同天然水体中对Fe(Ⅲ)离子配合作用的影响。 | Khalil M M H Mohamed G G Ismail E H Zayed M E Kamel B A | 2012 | 无机化学学报2012，28，7： | 1 |
| 15 | Evaluation and Adaptation of the EGM2008 Geopotential Model Along the Northern Nile Valley, Egypt: Case Study显示文摘 | Dawod G Mohamed H Ismail S | 2010 | Journal of Surveing Engineering2010，136，： | 1 |
| 16 | Morpho-tectonic analysis of the Tekeze River and the Blue Nile drainage systems on the Northwestern Plateau, Ethiopia显示文摘 | ISMAIL E H ABDELSALAM M G | 2012 | Journal of African earth sciences2012，69，： | 1 |
| 17 | Studies on extrusion conditions of some cereals and legumes显示文摘 | Ismail F A Zahran G H | 2002 | Egyptian Journal of Food Science2002，30，1： | 1 |
| 18 | S100A4 overexpression proves to be independent marker for breast cancer progression显示文摘 | Ismail NI Kaur G Hashim H | 2008 | Cancer Cell Int2008，10，8： | 1 |
| 19 | The performance of a solar regenerated open cycle desiccant bed grain cooling system显示文摘 | Ismail M Z Angus D E Thorpe G R | 1991 | Solar Energy1991，46，2： | 1 |
| 20 | Induction of Gentiarm cruciata hairy roots and their secondary metabolites 显示文摘 | SADIYE H AYNUR G ISMAIL H A | 2011 | Biologia2011，66，4： | 1 |
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