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| 1 | Effects of drinking water supplementation with Lactobacillus reuteri,and a mixture of reuterin and microcin J25 on the growth performance,caecal microbiota and selected metabolites of broiler chickens显示文摘Background:Since the overuse of antibiotics in animal production has led to a selection of antibiotic-resistant pathogens that affect humans and animals as well.Scientists are therefore searching for novel natural alternatives to antibiotics.In this study Lactobacillus reuteri and a combination of reuterin and microcin J25(RJ)were evaluated as promoters of growth and modulators of the cecal microbiota and metabolite profiles in broiler chickens.Oneday-old Cobb 500 male broilers were distributed to 8 treatments:negative control(without antibiotic),positive control(bacitracin),three concentrations of RJ and three doses of L.reuteri plus glycerol.The birds(2176,34 per pen,8 pens per treatment)were reared for 35 d.Results:The body weight of the bacitracin and 5 mmol/L reuterin combined with 0.08μmol/L microcin J25(10RJ)treatment group was significantly higher than that of the negative control group(P<0.05).L.reuteri had no significant effect on broiler growth.MiSeq high-throughput sequencing of 16S rRNA showed clustering of cecal microbial operational taxonomic unit diversity according to treatment.The influence of bacitracin and 10RJ on bacterial community overall structure was similar.They promoted Ruminococcaceae,Lachnospiraceae and Lactobacillaceae,increased the relative abundance of Faecalibacterium and decreased the abundance of Bacteroides and Alistipes,while the negative control condition favored Bacteroidaceae and Rikenellaceae.Furthermore,10RJ increased the concentration of short-chain fatty acid in the cecum and changed the metabolome overall.Conclusions:These overall suggest that 10RJ can promote a host-friendly gut environment by changing the cecal microbiome and metabolome.This combination of natural antimicrobial agents in the drinking water had a positive effect on broiler growth and may be suitable as an alternative to antibiotic growth promoters. | Liya Zhang Laila Ben Said Nadège Hervé Séverine Zirah Moussa Sory Diarra Ismail Fliss | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 1 |
| 2 | Immunomodulating effects of whey proteins and theirenzymatic digetsts显示文摘 | Amlelie Mereier Sylive F Gauthier Ismail Fliss | 2004 | International Dairy Journal2004，14，： | 1 |
| 3 | Immunomodulating effects of whey proteins and theirenzymatic digests显示文摘 | Am!elie Mercier Sylvie F Gauthier Ismail Fliss | 2004 | International Dairy Journal2004，14，： | 1 |
| 4 | Current trends in antimicrobial agent research: chemo- and bioinformatics approaches显示文摘 | Riadh Hammami Ismail Fliss | 2010 | Drug Discovery Today2010，，： | 1 |
| 5 | Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications显示文摘 | Rima Hatoum Steve Labrie Ismail Fliss | 2012 | Frontiers in Microbiology2012，，： | 1 |
| 6 | Allergenicity of acidic peptides from bovine β -lactoglobulin is reduced by hydrolysis with Bifidobacterium lactis NCC362 enzymes显示文摘 | Guénolée Prioult Sophie Pecquet Ismail Fliss | 2004 | International Dairy Journal2004，，5： | 1 |
| 7 | Immunomodulating effects of whey proteins and their enzymatic digests显示文摘 | AmLelie Mercier Sylvie F Gauthier Ismail Fliss | 2004 | International Dairy Journal2004，14，： | 1 |
| 8 | Inactivation of pectin methylesterase and stabilization of opalescence in orange juice by dynamic high pressure显示文摘 | Nadine Lacroix Ismail Fliss Joseph Makhlouf | | 0，，38： | 1 |
| 9 | New three-stage invitro model for infant colonic fermentation with immobilized fecal microbiota 显示文摘 | CECILE CINQUIN GWENAELLE Le BLAY ISMAIL FLISS | 2006 | FEMS Microbiol Ecol2006，57，： | 1 |
| 10 | Bioactivity of mackerel peptides on obesity and insulin resistance,an in-vivo study显示文摘Of many metabolic irregularity risk factors,glucose intolerance,insulin resistance,and abdominal obesity are the main ones.The risk of vascular diseases and cancers is rather high in such individuals therefore its treatment and prevention are equally important for the health of population.Marine including fish biopeptides have frequently shown to prevent and or ameliorate these risk factors.In our earlier studies,Atlantic mackerel hydrolysate and its fractions showed promising effects on immunity and hypertension.We,therefore,in the current study,aimed to examine the effects of mackerel hydrolysate along its cationic peptides,isolated at pH3 using electrodialysis with ultrafiltration membrane,on metabolic disorder factors in diet-induced insulin resistant obese mice.Mice were fed the chow and or the hypercaloric diet (high fat high sucrose) for the duration of 8-weeks.Subsequently the hypercaloric fed insulin resistant obese mice were gavaged daily either the vehicle and or the test material at the dosage of 208 mg of sample protein per kg mice body weight.According to our observations,mackerel peptides could not effectively modulate food intake,weight gain,adiposity,plasma glucose and insulin concentrations,hepatic cholesterol,and triglyceride levels.Thus,obesity and metabolic impairments could not be averted by the treatments in insulin resistant obese mice.In conclusion,anti-hypertensive,and immunomodulatory attributes of mackerel peptides at the tested concentrations do not seem to be correlated with its metabolic syndrome benefiting effects.To presume a general statement about the metabolic syndrome benefiting potency of Atlantic mackerel's biopeptides further research is warranted. | Soheila Abachi Hokmabadinazhad Jean-Philippe Songpadith Vanessa P.Houde Geneviève Pilon Ismail Fliss André Marette Laurent Bazinet Lucie Beaulieu | 2022 | Food Bioscience2022，47，3： | 0 |
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