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| 1 | Mechanisms of immune checkpoint inhibitormediated liver injury显示文摘The immune checkpoints,cytotoxic T-lymphocyte-associated antigen 4(CTLA-4) and programmed cell death protein-1/ligand-1(PD-1/PD-L1) are vital contributors to immune resulation and tolerance.Recently immune checkpoint inhibitors(ICIs) have revolutionized cancer therapy;however,they come with the cost of immune related adverse events involving multiple organs such as the liver.Due to its constant expo sure to foreign antigens,the liver has evolved a high capacity for immune tolerance,therefore,blockade of the immune checkpoints can result in aberrant immune activation affecting the liver in up to 20% of patients depending on the agent(s) used and underlying factors.This type of hepatotoxicity is termed immune mediated liver injury from checkpoint inhibitors(ILICI) and is more common when CTLA4 and PD-1/PDL1 are used in combination.The underlying mechanisms of this unique type of hepatotoxicity are not fully understood;however,the contribution of CD8^(+) cytotoxic T lymphocytes,various CD4^(+) T cells populations,cytokines,and the secondary activation of the innate immune system leading to liver injury have all been suggested.This review summarizes our current understanding of the underlying mechanisms of liver injury in immunotherapy using animal models of ILICI and available patient data from clinical studies. | Layla Shojaie Myra Ali Andrea Iorga Lily Dara | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 6 |
| 2 | Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice 显示文摘 | Iorga A Dewey S Partow-Navid R | 2012 | PLoS One2012，7，48： | 1 |
| 3 | Analysis of 3D random chopped fiber reinforced composites using FEM and random sequential adsorption 显示文摘 | Pan Y Iorga L Pelegri A A | 2008 | Computational Materials Science2008，43，： | 1 |
| 4 | Cytoplasmic lipid droplets and mitochondrial distribution in equine oocytes: Implications on oocyte maturation, fertilization and developmental competence after ICS显示文摘 | Ambruosi B Lacalandra GM Iorga AI | 2009 | Theriogenology2009，71，7： | 1 |
| 5 | A Review of H∞ Robust Control of Piezoelectric Smart Structures显示文摘 | Iorga L Baruh H Ursu I | | 0，，4： | 1 |
| 6 | Effect of SEBS on morphology, thermal, and mechanical properties of PP/organoclay nanocomposites显示文摘 | Zina Vuluga Denis Mihaela Panaitescu Constantin Radovici Cristian Nicolae Michaela Doina Iorga | 2012 | Polymer Bulletin2012，，9： | 1 |
| 7 | Sensitivity of cloud albedo to aerosol concentration and spectral dispersion of cloud droplet size distribution 显示文摘 | Iorga G Stefan S | 2007 | Atm6sfera2007，20，3： | 1 |
| 8 | Long - term clinical and econonfic outcomes associated with angiotensin I/receptor blocker use in hyperten- sive patients 显示文摘 | Swindle JP Buzinec P Iorga SR | 2011 | Curr Med Res Opin2011，27，9： | 1 |
| 9 | Numerical generation of a random chopped fiber composite RVE and its elastic properties 显示文摘 | PAN Y IORGA L PELEGRI A A | 2008 | Composites Seienee and Technology2008，68，： | 1 |
| 10 | Intralipid, a clinically safe compound, protects the heart against isehemia- reperfusion injury more efficiently than eyelosporine-A显示文摘 | LI J IORGA A SHARMA S | 2012 | Anesthesiology2012，117，4： | 1 |
| 11 | Management driven hybrid multicast framework for content aware networks显示文摘 | Iorga R Borcoci E Miruta R | 2014 | IEEE Communication Magazine2014，52，1： | 1 |
| 12 | Long-term clinical and economic outcomes associated with angiotensin II receptor blocker use in hypertensive patients显示文摘 | Swindle JP Buzinec P Iorga SR | 2011 | Curr Med Res Opin2011，，： | 1 |
| 13 | Model Fitting and Model Evidence for Multiscale Image Texture Analysis显示文摘 | Datcu Mihai Stoichescu Dan Alexandru Seidel Klaus Iorga Cristian | 2004 | AIP Conference Proceedings2004，735，1： | 1 |
| 14 | Intralipid,a clinically safe compound,protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A显示文摘 | Li JY Iorga A Sharma S | 2012 | Anesthesiology2012，117，4： | 1 |
| 15 | A review of H∞ robust control of piezoelectric smart structures 显示文摘 | Iorga L Baruh H Ursu I | 2008 | Applied Mechanics Review2008，61，4： | 1 |
| 16 | Analysis of 3D random chopped fiber reinforced composites using FEM and random sequential adsorption显示文摘 | Pan Y Iorga L Pelegri A A | 2008 | Computational Materials Science2008，43，3： | 1 |
| 17 | Estrogen rescues preexisting severe pulmonary hypertension in rats 显示文摘 | Umar S Iorga A Matori H | 2011 | Am J Respir Crit Care Med2011，184，6： | 1 |
| 18 | Assessment of Patulin Content in Apple Puree and Apple and Fruit Puree by High Performance Liquid Chromatography显示文摘 | Monica Catana Luminita Catana Enuta Iorga Mioara Negoita Valentin Ionescu Nastasia Belc Dragos Efstatiade Hassan Y. Aboul-Enein | 2016 | Journal of Environmental Science and Engineering(A)2016，5，7： | 0 |
| 19 | Analysis and Evaluation of the Acrylamide Levels in Some Bread Assortments on the Romanian Market by GC-MS/MS显示文摘 | Mioara Negoita Enuta Iorga Alina Adascalului Luminita Catana Nastasia Belc Andreea Stan DragosEfstatiade Hassan Y. Aboul-Enein | 2016 | Journal of Environmental Science and Engineering(A)2016，5，4： | 0 |
| 20 | Influence of Relative Electrode-Electrolyte Movement over Productivity for Silver Recovery from Diluted Solutions显示文摘 | Mirela Ioana Iorga Marius Constantin Mirica Ionel Balcu Nicolae Mirica Dan Rosu | 2011 | Journal of Chemistry and Chemical Engineering2011，5，4： | 0 |
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