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| 1 | Role of the metabolism of branched-chain amino acids in the development of Alzheimer’s disease and other metabolic disorders显示文摘Alzheimer’s disease is an incurable chronic neurodegenerative disorder and the leading cause of dementia,imposing a growing economic burden upon society.The disease progression is associated with gradual deposition of amyloid plaques and the formation of neurofibrillary tangles within the brain parenchyma,yet severe dementia is the culminating phase of the enduring pathology.Converging evidence suggests that Alzheimer’s disease-related cognitive decline is the outcome of an extremely complex and persistent pathophysiological process.The disease is characterized by distinctive abnormalities apparent at systemic,histological,macromolecular,and biochemical levels.Moreover,besides the well-defined and self-evident characteristic profuse neurofibrillary tangles,dystrophic neurites,and amyloid-beta deposits,the Alzheimer’s disease-associated pathology includes neuroinflammation,substantial neuronal loss,apoptosis,extensive DNA damage,considerable mitochondrial malfunction,compromised energy metabolism,and chronic oxidative stress.Likewise,distinctive metabolic dysfunction has been named a leading cause and a hallmark of Alzheimer’s disease that is apparent decades prior to disease manifestation.State-of-theart metabolomics studies demonstrate that altered branched-chain amino acids(BCAAs)metabolism accompanies Alzheimer’s disease development.Lower plasma valine levels are correlated with accelerated cognitive decline,and,conversely,an increase in valine concentration is associated with reduced risk of Alzheimer’s disease.Additionally,a clear BCAAs-related metabolic signature has been identified in subjects with obesity,diabetes,and atherosclerosis.Also,arginine metabolism is dramatically altered in Alzheimer’s disease human brains and animal models.Accordingly,a potential role of the urea cycle in the Alzheimer’s disease development has been hypothesized,and preclinical studies utilizing intervention in the urea cycle and/or BCAAs metabolism have demonstrated clinical potential.Continual failures to offer a competent treatment strategy directed against amyloid-beta or Tau proteins-related lesions,which could face all challenges of the multifaceted Alzheimer’s disease pathology,led to the hypothesis that hyperphosphorylated Tau and deposited amyloid-beta proteins are just hallmarks or epiphenomena,but not the ultimate causes of Alzheimer’s disease.Therefore,approaches targeting amyloid-beta or Tau are not adequate to cure the disease.Accordingly,the modern scientific vision of Alzheimer’s disease etiology and pathogenesis must reach beyond the hallmarks,and look for alternative strategies and areas of research. | Baruh Polis Abraham O.Samson | 2020 | Neural Regeneration Research2020，15，8： | 10 |
| 2 | Captive but mobile: Privacy concerns andremedies for the mobile environment 显示文摘 | Popescu M Baruh L | 2013 | The Information Society2013，29，5： | 1 |
| 3 | Dynamics and control of atranslating flexible beam with a prismatic joint 显示文摘 | Tadikonda S S K Baruh H | 1992 | ASME Journal of Dynamic Systems1992，114，： | 1 |
| 4 | Sensor placement in structural control 显示文摘 | BARUH H CHOE K | 1991 | Journal of Guidance Control and Dynamics1991，15，1： | 1 |
| 5 | Sensor failure detection method for flexible structures显示文摘 | Baruh H Choe K | 1987 | Journal of Guidance Control and Dynamics1987，10，5： | 1 |
| 6 | A comparison of control techniques for large flexible systems显示文摘 | Meirovitch L Baruh H | 1983 | Guidanee1983，6，4： | 1 |
| 7 | Damage detection in the flexible structures显示文摘 | BARUH H RATAN S | 1993 | Journal of Sound and Vibration1993，166，1： | 1 |
| 8 | Modeling and identification of boundary conditions in flexible structures显示文摘 | H Baruh J B Boka | | 0，，02： | 1 |
| 9 | A Review of H∞ Robust Control of Piezoelectric Smart Structures显示文摘 | Iorga L Baruh H Ursu I | | 0，，4： | 1 |
| 10 | Retinal and choroidal vascular occlusion secondry to corticosteroid emboli sation显示文摘 | MORGAN C M BARUH E | 1989 | Br J Ophthalmol1989，73，1： | 1 |
| 11 | A closed-form solution procedure for circular cylindrical shell vibrations显示文摘 | Callahan J Baruh H | 1999 | International Journal of Solids and Structures1999，36，： | 1 |
| 12 | On-line identification and location of rotor cracks 显示文摘 | Baruh H Rodrigucz J | 1996 | Journal of Sound and Vibraton1996，194，1： | 1 |
| 13 | Modeling and identification of boundary conditions in flexible structures显示文摘 | Baruh H Boka J B | 1993 | Journal of Analytical and Experimental Modal Analysis1993，8，2： | 1 |
| 14 | Sensor placement in structural control显示文摘 | Baruh H Choc K | 1990 | Jurnal of Gudiance Control and Dynamics1990，13，3： | 1 |
| 15 | Retinal and choroi- dal vascular occlusion secondary to corticosteroid embolisation 显示文摘 | Wilkinson WS Morgan CM Baruh E | 1989 | Br J Ophthalmol1989，73，1： | 1 |
| 16 | Issues in the dynam- ics and control of flexible robot manipulators 显示文摘 | BARUH H TADIKONDA S S K | 1989 | Jour- nal of Guidance Control and Dynamics1989，12，5： | 1 |
| 17 | Acomparison of control techniques for large flexible systems显示文摘 | Meirovith L Baruh H Oz H L | 1983 | Journal of Guidance andControl1983，6，30： | 1 |
| 18 | Sensor and actuator placement in structure control显示文摘 | BARUH H CHOCK | 1990 | Journal of Guidance Control and Dynamics1990，13，3： | 1 |
| 19 | On-line Identifica- tion and Location of Rotor Cracks 显示文摘 | Ratan S Baruh H Rodriguez J | 1996 | Journal of Sound and Vibration1996，194，1： | 1 |
| 20 | On-line identification and location of rotor cracks 显示文摘 | RATAN S BARUH H RODRIGUEZ J | 1996 | Journal of Sound and Vibration1996，194，1： | 1 |
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