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| 1 | Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase显示文摘AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small intestine.METHODS:For this study,primary culture of ICCs was prepared from the small intestine of the mouse.LPS was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp technique.Immunocytochemistry was used to examine the expression of the proteins in ICCs.RESULTS:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) synthase.Toll-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ICCs.Catalase(antioxidant agent) had no action on LPS-induced action in ICCs.LPS actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not NO.CONCLUSION:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions. | Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun | 2013 | World Journal of Gastroenterology2013，19，8： | 9 |
| 2 | Identification of TRPM7 channels in human intestinal interstitial cells of Cajal显示文摘AIM:To investigate the characteristics of slow elec-trical waves and the presence of transient receptor potential melastatin-type 7(TRPM7)in the human gas-trointestinal(GI)tract.METHODS:Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue.Immunohisto-chemistry was used to identify TRPM7 channels in in-terstitial cells of Cajal(ICCs).RESULTS:The human GI tract generated slow electri-cal waves and had ICCs which functioned as pacemak-er cells.Flufenamic acid,a nonselective cation channel blocker,and 2-APB(2-aminoethoxydiphenyl borate)and La3+,TRPM7 channel blockers,inhibited the slowwaves.Also,TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION:These results suggest that the human GI tract generates slow waves and that TRPM7 chan-nels expressed in the ICCs may be involved in the gen-eration of the slow waves. | Byung Joo Kim Kyu Joo Park Hyung Woo Kim Seok Choi Jae Yeoul Jun In Youb Chang Ju-Hong Jeon Insuk So Seon Jeong Kim | 2009 | World Journal of Gastroenterology2009，15，46： | 3 |
| 3 | TomatoNet A Genome-wide Co-functional Network for Unveiling Complex Traits of Tomato, a Model Crop for Fleshy Fruits显示文摘 | Hyojin Kim Bong Suk Kim Jung Eun Shim Sohyun Hwang Sunmo Yang Eiru Kim Aniafi S. Iver-Pascuzzi2 Insuk Lee | 2017 | Molecular Plant2017，10，4： | 1 |
| 4 | Usefulness of Artificial Neural Networks for Early Warning System of Economic Crisis 显示文摘 | Tae Yoon Kim Kyong Joo Oh Insuk Sohn Changha Hwang | 2004 | Expert Systems with Applications2004，26，4： | 1 |
| 5 | Inhibition of pacemaker currents by nitric oxide via activation of ATP-sensitive K+ channels in cultured interstitial cells of Cajal from the mouse small intestine显示文摘 | Chan Guk Park Young Dae Kim Man Yoo Kim Jun Soo Kim Seok Choi Cheol Ho Yeum Shankar Prasad Parajuli Jong Seong Park Han Seong Jeong Insuk So Ki Whan Kim Jae Yeoul Jun | 2007 | Naunyn - Schmiedeberg’s Archives of Pharmacology2007，，3： | 1 |
| 6 | Progesterone receptor isoform ration of human fetal membranes increases during term parturition显示文摘 | Soo-young Oh Chong JK Insuk P | 2005 | Am J Obstet Gynecol2005，1913，： | 1 |
| 7 | Synthesis of dimethyl carbonate by vapor phase oxidative carbonylation of methanol over Cubased catalysts 显示文摘 | Man Seok Han Byung Gwon Lee Insuk Suh | 2001 | Joumal of Molecular Catalysis A: Chemical2001，170，： | 1 |
| 8 | Progesterone re- ceptor isoform ratio of human fetal membranes increases during term parturition显示文摘 | Soo-Young Oh Chong JK Insuk P | 2005 | Am J Obstet Gynecol2005，193，32： | 1 |
| 9 | Serial bone scans in orchiectomized men with prostatic bone metastase显示文摘 | Sy W M Paul F Insuk S | 1981 | Clin Nucl Med1981，6，： | 1 |
| 10 | Usefulness of artificial neural networks for early warning system of economic crisis显示文摘 | Kyong Joo Oh Insuk Sohn Changha Hwang | 2004 | Expert Systems with Applications2004，，： | 1 |
| 11 | Volume-sensitive chloride current activated by hyposmotic swelling in antral gastric myocytes of the guinea-pig显示文摘 | Wen Xie Xu Sung Joon Kim Insuk So Tong Mook Kang Jong Chul Rhee K. W. Kim | 1997 | Pflügers Archiv1997，，1： | 1 |
| 12 | Effect of stretch on calcium channel currents recorded from the antral circular myocytes of guinea-pig stomach显示文摘 | Wen Xie Xu Sung Joon Kim Sang Jeong Kim Insuk So Tong Mook Kang Jong Chul Rhee Ki Whan Kim | 1996 | Pflügers Archiv European Journal of Physiology1996，，2： | 1 |
| 13 | Regulation of AMPA receptors during synaptic plasticity显示文摘 | Insuk Song Richard L Huganir | 2002 | Trends in Neurosciences2002，，11： | 1 |
| 14 | Serial bone scans in orchiectomized men with prosta- lic bone mesln显示文摘 | Sy WM Paul F Insuk S | 1986 | Clha Nucl Med1986，6，： | 1 |
| 15 | Bending quality of main Korean wood species 显示文摘 | Hwang K Jung Insuk Lee Weonhee | 2002 | Wood Research2002，，89： | 1 |
| 16 | Synthesis of dimethyl carbonate by vapor phase oxidative carbonylation of methanol over Cu- based catalysts显示文摘 | Man Seok Han Byung Gwon Lee Insuk Suh | 2001 | Journal of Molecular Catalysis A: Chemical2001，170，12： | 1 |
| 17 | Sparse representation based target detection in frared image显示文摘 | Shujuan G Insuk K and Seong T J | 2013 | International Journal of Energy Information and Communications2013，4，6： | 1 |
| 18 | Progesterone receptor isoform (A/B) ratio of human fetal membranes increases during term parturition显示文摘 | Chong J K Insuk P | 2005 | Am J Obstet Gynecol2005，193，： | 1 |
| 19 | Reciprocal positive regulation between TRPV6 and NUMB in PTEN-deficient prostate cancer cells显示文摘 | Sung-Young Kim Chansik Hong Jinhong Wie Euiyong Kim Byung Joo Kim Kotdaji Ha Nam-Hyuk Cho In-Gyu Kim Ju-Hong Jeon Insuk So | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 20 | Intestinal bacterial metabolism of flavonoids and its relation to some biological activities显示文摘 | KIM Donghyun JUNG Eunah SOHNG Insuk | 1998 | Arch Pharma Res1998，21，1： | 1 |
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