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| 1 | Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats显示文摘AIM:To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease(NAFLD).METHODS:Male Wistar rats were fed either a control diet(control group)or a high-fat diet(HFD).After 4wk,the HFD-fed rats were subdivided into two groups;one group was injected with exenatide[HFD-Ex(+)group]and the other with saline[HFD-Ex(-)group]every day for 12 wk.The control group received saline and were fed a control diet.Changes in weight gain,energy intake,and oxygen consumption were analyzed.Glucose tolerance tests were performed after 8 wk of treatment.Histological assessments were performed in liver and adipose tissue.RNA expression levels of lipid metabolism related genes were evaluated in liver,skeletal muscle,and adipose tissue.RESULTS:Exenatide attenuated weight gain[HFDEx(-)vs HFD-Ex(+)]and reduced energy intake,which was accompanied by an increase in oxygen consumption and a decrease in the respiratory exchange ratio[HFD-Ex(-)vs HFD-Ex(+)].However,exenatide did not affect glucose tolerance.Exenatide reduced lipid content in the liver and adipose tissue.Exenatide did not affect the expression of lipid metabolism-related genes in the liver or skeletal muscle.In adipose tissue,exenatide significantly upregulated lipolytic genes,including hormone-sensitive lipase,carnitine palmitoyltransferase-1,long-chain acyl-CoA dehydrogenase,and acyl-CoA oxidase 1[HFD-Ex(-)vs HFD-Ex(+)].Exenatide also upregulated catalase and superoxide dismutase 2[HFD-Ex(-)vs HFD-Ex(+)].CONCLUSION:In addition to reducing appetite,enhanced lipid use by exenatide in adipose tissue may reduce hepatic lipid content in NAFLD,most likely by decreasing lipid influx into the liver. | Kosuke Tanaka Yuko Masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta Masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi | 2014 | World Journal of Gastroenterology2014，20，10： | 6 |
| 2 | Treatment of laryngeal granuloma显示文摘 | Inoguchi S Nakajima T | 2001 | Otolaryngol Head Neck Surg(tokyo)2001，73，： | 1 |
| 3 | The lack of the C - terminal domain of adipose triglyeeride li- pase causes neutral lipid storage disease through impaired interactions with lipid droplets显示文摘 | KOBAYASHI K INOGUCHI T MAEDA Y | 2008 | Journal of Clinical En- docrinology and Metabolism2008，93，： | 1 |
| 4 | Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6—a role of NAD(P)H oxidase in β-cells显示文摘 | Hirotaka Tsubouchi Toyoshi Inoguchi Mieko Inuo Maiko Kakimoto Toshiyo Sonta Noriyuki Sonoda Shuji Sasaki Kunihisa Kobayashi Hideki Sumimoto Hajime Nawata | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 5 | On time-like surfaces of positive constant Gaussian curvature and imaginary principal curvatures显示文摘 | Gu C H Hu H S Inoguchi J | 2002 | J Geom Phys2002，41，： | 1 |
| 6 | High glucose level and free fatty acid stimulates reactive oxygen speies production through protein knase C-dependent activation of NADP(H)oxidase in culture vascular cells显示文摘 | Inoguchi T Li P Umeda F Yu HY Kakimoto M Imamura M | 2000 | Diabetes2000，49，11： | 1 |
| 7 | Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells显示文摘 | H. Y. Yu T. Inoguchi M. Kakimoto N. Nakashima M. Imamura T. Hashimoto F. Umeda H. Nawata | 2001 | Diabetologia2001，，5： | 1 |
| 8 | Reduction of urinary albumin excretion by thromboxane synthetase inhibitor, OKY- 046,through modulating renal prostaglandins in patients with diabetic nephropathy显示文摘 | Tajiri Y Inoguchi T Umeda F | 1990 | Diabetes Res Clin Pract1990，10，3： | 1 |
| 9 | Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells显示文摘 | Sekiguchi N Inoguchi T Kobayashi K | | 0，，01： | 1 |
| 10 | Effect of eicosapentaenoic acid on glouseinduced abnormal retinal blood flow via the diacylaly cerol protein Kinase C pathway显示文摘 | Inoguchi T Ve Meda F | 1995 | Am J Physiol1995，239，： | 1 |
| 11 | Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice显示文摘 | Fujii M Inoguchi T Maeda Y | 2007 | Kidney Int2007，72，4： | 1 |
| 12 | Adenovirus-mediated high expression of resistin causes dyslipidemia in mice显示文摘 | Sato N Kobayashi K Inoguchi T | 2005 | Endocrinology2005，146，1： | 1 |
| 13 | Chronic sulfonylurea treatment and hyperglycemia aggravate disproportionately elevated plasma proinsulin levels in patients with type 2 diabetes显示文摘 | Inoguchi T Umeda F Kakimoto M | 2000 | Endocr J2000，47，： | 1 |
| 14 | The role of oxidative stress in the pathogenesis of diabetic vascular complications 显示文摘 | Sasaki S Inoguchi T | 2012 | Dia- betes Metab J2012，36，4： | 1 |
| 15 | High inscose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P) H oxidase in cultured vascular cells显示文摘 | Inoguchi T Li P Umeda F | 2000 | Diabetes2000，49，11： | 1 |
| 16 | Non-occupational exposure of adult women in Manila, the Philippines, to lead and cadmium显示文摘 | Z.-W Zhang R.D Subida M.G Agetano H Nakatsuka N Inoguchi T Watanabe S Shimbo K Higashikawa M Ikeda | 1998 | Science of the Total Environment1998，，1： | 1 |
| 17 | Weierstrass Type Represen- tation of Timelike Surface with Constant Mean Curvature 显示文摘 | Dorfmeister J Inoguchi J Toda M | 2002 | Dif- ferential Gometry and Integrable Systems Contem-porary Mathe- matics AMS2002，308，： | 1 |
| 18 | High glucose leveland free fatty acid stimulate reactive oxygen species pro-duction through protein kinase C-dependent activation ofNAD( P) H oxidase in cultured vascular cells 显示文摘 | INOGUCHI T LI P UMEDA F | 2000 | Diabe-tes2000，49，11： | 1 |
| 19 | High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD (P) H oxidase in cultured vascular cells 显示文摘 | Inoguchi T Li P Umeda F | 2000 | Diabetes2000，49，11： | 1 |
| 20 | High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD (P) H oxidase in cultured vascular cells显示文摘 | Inoguchi T Li P Umeda F | 2000 | Diabetes2000，49，11： | 1 |
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