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| 1 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | Costimulation,coinhibition and cancer显示文摘 | Inman B A Frigola X Dong H | 2007 | Curr Cancer Drug Targets2007，7，1： | 1 |
| 3 | Lipophilic stinging nettle extracts possess potent anti-inflammatory activity,are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders显示文摘 | Johnson T A Sohn J Inman W D | 2013 | Phytomedicine2013，20，2： | 1 |
| 4 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 5 | Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats 显示文摘 | INMAN S R PLOTT W K POMILEE R A | 2003 | Transplantation2003，75，10： | 1 |
| 6 | The impact of logistics performance on organizational performance in a supply chain context显示文摘 | Green Jr K W Whitten D Inman g A | 2008 | Supply Chain Management: An International Journal2008，13，4： | 1 |
| 7 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 8 | Urachal anomalies:a lon- gitudinal study of uraehal remnants in children and adults显示文摘 | Ashley R A Inman B A Routh J C | 2007 | JUrol2007，178，4： | 1 |
| 9 | Electron microscopic observations of the stratum corneum intercellular lipids in normal and atopic dogs显示文摘 | Inman A O Olivry T O Dunston S M | 2001 | Vet Pathol2001，38，： | 1 |
| 10 | Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line显示文摘 | N A Monteiro-Riviere A O Inman L W Zhang | 2009 | Toxicology and Applied Pharmacology2009，234，1： | 1 |
| 11 | Image analysis for the identification of the quarantine pest Tilletia indica显示文摘 | Chesmore D Bernard T Inman A J | 2003 | EPPO Bulletin2003，33，3： | 1 |
| 12 | Multi-walled carbon nanotube interactions with human epidermal keratinocytes 显示文摘 | Monteiro-Rivierea N A Nemanich R J Inman A O | 2005 | Toxicol Lett2005，155，： | 1 |
| 13 | Challenges for assessing carbon nanomaterial toxicity to the skin显示文摘 | Monteiro-Riviere N A Inman A O | 2006 | Carbon2006，44，6： | 1 |
| 14 | Costimulation, coinhibition and cancer显示文摘 | Inman B A Frigola X Dong H | 2007 | Curr Cancer Drug Targets2007，7，1： | 1 |
| 15 | Fre- quency range selection for impedance-based structural health monitoring 显示文摘 | PEAIRS D M TARAZAGA P A INMAN D J | 2007 | Journal of Vibration and Acoustics2007，129，6： | 1 |
| 16 | Total JIT(T-JIT)and Its Impact on Supply Chain Competency and Organizational Performance显示文摘 | Green Jr K W Inman R A Birou L M | 2014 | International Journal of Production Economics2014，147，： | 1 |
| 17 | Modified goal chasing for products with non-zero/one bills of materials显示文摘 | Cakir A Inman R R | 1993 | International Journal of Production Research1993，31，1： | 1 |
| 18 | The potential of land conservation agreements for protection of water resources显示文摘 | Smith L Inman A Cherrington R | 2012 | Environmental Science and Policy2012，24，： | 1 |
| 19 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 20 | Urachal car cinoma- clinicopathologic features and long term out- comes of an aggressive malignancy显示文摘 | Ashley R A Inman B A Sebo T J | 2006 | Cancer2006，107，4： | 1 |
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