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| 1 | Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections显示文摘Alcohol use disorder(AUD) and hepatitis C virus(HCV) infection frequently co-occur. AUD is associated with greater exposure to HCV infection, increased HCV infection persistence, and more extensive liver damage due to interactions between AUD and HCV on immune responses, cytotoxicity, and oxidative stress. Although AUD and HCV infection are associated with increased morbidity and mortality, HCV antiviral therapy is less commonly prescribed in individuals with both conditions. AUD is also common in human immunodeficiency virus(HIV) infection, which negatively impacts proper HIV care and adherence to antiretroviral therapy, and liver disease. In addition, AUD and HCV infection are also frequent within a proportion of patients with HIV infection, which negatively impacts liver disease. This review summarizes the current knowledge regarding pathological interactions of AUD with hepatitis C infection, HIV infection, and HCV/HIV co-infection, as well as relating to AUD treatment interventions in these individuals. | Daniel Fuster Arantza Sanvisens Ferran Bolao Inmaculada Rivas Jordi Tor Robert Muga | 2016 | World Journal of Hepatology2016，8，31： | 4 |
| 2 | Development of a framework for fire risk assessment using remote sensing and geographic information system technologies显示文摘 | Emilio Chuvieco Inmaculada Aguado Marta Yebra Héctor Nieto Javier Salas M. Pilar Martín Lara Vilar Javier Martínez Susana Martín Paloma Ibarra Juan de la Riva Jaime Baeza Francisco Rodríguez Juan R. Molina Miguel A. Herrera Ricardo Zamora | 2008 | Ecological Modelling2008，，1： | 1 |
| 3 | A ternary-arithmetic topological based algebraic method for networks traffic observability显示文摘 | Enrique Castillo Pilar Jiménez José María Menéndez Ana Rivas Inmaculada Gallego | 2011 | Applied Mathematical Modelling2011，，11： | 1 |
| 4 | Monitoring hepatitis C virus treatment rates in an Opioid Treatment Program:A longitudinal study显示文摘BACKGROUND Direct-acting antivirals(DAAs)are recommended for the treatment of hepatitis C virus(HCV)infection in patients treated with methadone or buprenorphine.AIM To assess HCV treatment rates in an Opioid Treatment Program(OTP).METHODS This longitudinal study included 501 patients(81.4%men,median age:45 years;interquartile range:39-50 years)enrolled in an OTP between October 2015 and September 2017.Patients were followed until September 2019.Data on sociodemographics,substance use,HCV infection,human immunodeficiency virus(HIV)infection and laboratory parameters were collected at entry.We analyzed medical records to evaluate HCV treatment.Kaplan-Meier methods and Cox regression models were used to analyze the DAA treatment uptake and to identify treatment predictors.RESULTS Prevalence of HCV and HIV infection was 70%and 34%,respectively.Among anti-HCV-positive(n=336)patients,47.2%,41.3%,and 31.9%used alcohol,cannabis,and cocaine,respectively.HCV-RNA tests were positive in 233(69.3%)patients.Twentyeight patients(8.3%)cleared the infection,and 59/308(19.1%)had received interferon-based treatment regimens before 2015.Among 249 patients eligible,111(44.6%)received DAAs.Treatment rates significantly increased over time from 7.8/100 person-years(p-y)(95%CI:5.0-12.3)in 2015 to 18.9/100 p-y(95%CI:11.7-30.3)in 2019.In a multivariate analysis,patients with HIV co-infection were twice as likely to receive DAAs(HR=1.94,95%CI:1.21-3.12)than patients with HCV mono-infection.Current drug use was an independent risk factor for not receiving treatment against infection(HR=0.48,95%CI:0.29-0.80).CONCLUSION HCV treatment is evolving in patients with HCV-HIV co-infection.Ongoing drug use while in an OTP might negatively impact the readiness to treat infection. | Arantza Sanvisens Inmaculada Rivas Eva Faure Néstor Espinach Anna Hernandez-Rubio Xavier Majó Joan Colom Robert Muga | 2020 | World Journal of Gastroenterology2020，26，38： | 0 |
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