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	题名	作者	年代	出处	被引量
1	Isolation of a small molecule with anti-MRSA activity from a mangrove symbiont Streptomyces sp.PVRK-1 and its biomedical studies in Zebrafish embryos显示文摘Objective:The aim of the present study was to isolate the anti-MRSA(Methicillin Resistant Staphylococcus aureus)molecule from the Mangrove symbiont Streptomyces and its biomedical studies in Zebrafish embryos.Methods:MRSA was isolated from the pus samples of Colachal hospitals and confirmed by amplification of mecA gene.Anti-MRSA molecule producing strain was identified by!6s rRNA gene sequencing.Anti-MRSA compound production was optimized by Solid State Fermentation(SSF)and the purification of the active molecule was carried out by TLC and RP-HPLC.The inhibitory concentration and LC_(50)were calculated using Statistical software SPSS.The Biomedical studies including the cardiac assay and organ toxicity assessment were carried out in Zebraiish.Results:The bioactive anti-MRSA small molecule A,was purified by TLC with Rf value of 0.37 with 1.389 retention time at RP-HPLC.The Inhibitory Concentration of the purified molecule A_2 was 30μg/mL but,the inhibitory concentration of the MRSA in the infected embryo was 32-34μg/mL for TLC purified molecule A,with LC_(50)mean value was61.504μg/mL.Zebrafish toxicity was assessed in 48-60μg/mL by observing the physiological deformities and the heart beat rates(HBR)of embryos for anti MRSA molecule showed the mean of 41.33-41.67 HBR/15 seconds for 40μg/mL and control was 42.33-42.67 for 15 seconds which significantly showed that the anti-MRSA molecule A_2 did not affected the HBR.Conclusions:Anti-MRSA molecule from Streptomyces sp PVRK-I was isolated and biomedical studies in Zebrafish model assessed that the molecule was non toxic at the minimal inhibitory concentration of MRSA.	Rajaretinam Rajesh Kannan Appadurai Muthamil Iniyan Vincent Samuel Gnana Prakashy	2011	Asian Pacific Journal of Tropical Biomedicine2011，1，5：	3
2	A review of solar thermal technologies显示文摘	THIRUGNANASAMBANDAM M INIYAN S GOIC R		0，，14：	1
3	A review of energy models 显示文摘	JEBARA J S INIYAN S	2006	Renew- able and Sustainable Energy Reviews2006，，10：	1
4	A review of wind energy technologies显示文摘	Herbert G M J Iniyan S Sreevalsan E	2007	Renewable and Sustainable Energy Reviews2007，11，6：	1
5	A review of solar photovoltaic technologies 显示文摘	PARIDA B INIYAN S GOIC R	2011	Renew Sust Energy Rev2011，15，3：	1
6	A review of solar photovoltaic technologies显示文摘	Bhubaneswari Parida S. Iniyan Ranko Goic	2011	Renewable and Sustainable Energy Reviews2011，，3：	1
7	A review of solar drying technologies 显示文摘	Vijaya Venkata Raman S Iniyan S Goic R	2012	Renewable and Sustainable Energy Reviews2012，16，5：	1
8	A review of solar thermal technologies 显示文摘	Thirugnanasambandam M Iniyan S Goic R	2010	Renew Sustainable Energy Rev2010，14，1：	1
9	A review of energy models 显示文摘	Jebaraj S Iniyan S	2006	Renewable and Sustainable Energy Reviews2006，10，：	1
10	The application of a Delphi technique in the linear programming optimization of future renewable energy options for India显示文摘	Iniyan S Sumathy K		0，，01：	1
11	An optimal renewable energy model for various end-uses显示文摘	INIYAN S SUMATHY K	2000	Energy2000，25，：	1
12	A review of wind en-ergy technologies 显示文摘	Herbert G M J Iniyan S Sreevalsan E	2007	Renewable & Sustainable Energy Reviews2007，11，6：	1
13	Review of Solar Photovoltaic Technologies显示文摘	PARIDA B INIYAN S GOIC R A	2011	Renewable and Sustainable Energy Review2011，15，3：	1
14	A review of energy models显示文摘	Jebaraj S Iniyan S	2006	Renewable and Sustainable Energy Reviews2006，，10：	1
15	A review of wind energy technologies显示文摘	Baker J H Iniyan S Sreevalsan E	2007	Renewable and Sustainable Energy Reviews2007，11，6：	1
16	A Review of Wind Energy Technologies显示文摘	JOSELIN HERBERT G M INIYAN S SREEVALSAN E	2007	Renewable sustainable Energy Reviews2007，11，6：	1
17	A review of energy models 显示文摘	JEBARAJS INIYANS	2006	Renewable and Sustainable Energy Reviews2006，，4：	1
18	The application of a Delphi technique in the linear programming optimization of future renewable energy options for India显示文摘	Iniyan S Suraathy K	2003	Biomass and Bioenergy2003，24，1：	1
19	The application of a Delphi technique in the linear programming optimization of future renewable energy options for India显示文摘	Iniyan S Sumathy K	2003	Biomass and Bioenergy2003，，24：	1
20	A review of wind energy technologies 显示文摘	Joselin Herbert G M Iniyan S E	2007	Renewable and Sustainable Energy Reviews2007，11，6：	1

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