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| 1 | Cynodon dactylon andSida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos显示文摘The aim of the present study was to screen cardioactive herbs from Western Ghats of India.The heart beat rate (HBR) and blood flow during systole and diastole were tested in zebrafish embryos.We found that Cynodon dactylon (C.dactylon) induced increases in the HBR in zebrafish embryos with a HBR of (3.968±0.344) beats/s,which was significantly higher than that caused by betamethosone [(3.770±0.344) beats/s].The EC 50 value of C.dactylon was 3.738 μg/mL.The methanolic extract of Sida acuta (S.acuta) led to decreases in the HBR in zebrafish embryos [(1.877±0.079) beats/s],which was greater than that caused by nebivolol (positive control).The EC 50 value of Sida acuta was 1.195 μg/mL.The untreated embryos had a HBR of (2.685±0.160) beats/s at 3 d post fertilization (dpf).The velocities of blood flow during the cardiac cycle were (2,291.667±72.169) μm/s for the control,(4,250±125.000) μm/s for C.dactylon and (1,083.333±72.169) μm/s for S.acuta.The LC 50 values were 32.6 μg/mL for C.dactylon and 20.9 μg/mL for S.acuta.In addition,the extracts exhibited no chemical genetic effects in the drug dosage range tested.In conclusion,we developed an assay that can measure changes in cardiac function in response to herbal small molecules and determine the cardiogenic effects by microvideography. | Rajaretinam Rajesh Kannan Samuel Gnana Prakash Vincent | 2012 | The Journal of Biomedical Research2012，26，2： | 5 |
| 2 | 红树林放线菌及其代谢产物多样性显示文摘红树林多变复杂的环境导致了红树林放线菌的多样性.近年来,在对红树林放线菌的研究中发现了许多独特的生物活性物质.通过对这些生物活性物质的提取以及药理研究,为新药的开发和各种疑难疾病的治愈提供了新的希望.该研究对红树林放线菌及其产生的活性代谢产物的多样性研究进展进行了综述,为进一步挖掘红树林放线菌资源提供参考. | 解修超 阮昌应 洪亮 杨建 | 2013 | 红河学院学报2013，11，4： | 2 |
| 3 | 耐甲氧西林金黄色葡萄球菌的研究及实验室检测进展显示文摘目前,病原菌耐药已经成为一个全球性的问题,越来越多的病原菌对常用抗菌药物产生耐药性,且耐药水平越来越高.其中金黄色葡萄球菌(Staphylococcusaureus,SA)已经成为医院感染和社区获得性感染的主要病原菌之一,并且极易出现多药耐药株,导致金黄色葡萄球菌引起的感染成为临床较为棘手的问题.尤其是耐甲氧西林金黄色葡萄球菌(methicillinre-sistantstaphylococcusaureus,MRSA)的出现,使得MRS八成为现有抗生素难以控制的医院感染菌,它具有传播途径广、 | 朱成宾 窦露 | 2014 | 国际检验医学杂志2014，35，A02： | 0 |
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